mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for UGP2
Gene summary
Basic gene Info.Gene symbolUGP2
Gene nameUDP-glucose pyrophosphorylase 2
SynonymsUDPG|UDPGP|UDPGP2|UGP1|UGPP1|UGPP2|pHC379
CytomapUCSC genome browser: 2p14-p13
Type of geneprotein-coding
RefGenesNM_001001521.1,
NM_006759.3,
DescriptionUDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferaseUTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1uridy
Modification date20141207
dbXrefs MIM : 191760
HGNC : HGNC
Ensembl : ENSG00000169764
HPRD : 08934
Vega : OTTHUMG00000129513
ProteinUniProt: Q16851
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UGP2
BioGPS: 7360
PathwayNCI Pathway Interaction Database: UGP2
KEGG: UGP2
REACTOME: UGP2
Pathway Commons: UGP2
ContextiHOP: UGP2
ligand binding site mutation search in PubMed: UGP2
UCL Cancer Institute: UGP2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for UGP2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D253D253HBLCA2
D253L255MCOAD1
K291G293WKIRC1
Q87S85LSTAD1
C181R182CSTAD1
K291G293RUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for UGP2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C181R182C-1.4732554
D253L255M-1.0464782
D253D253H-0.59184614
K291G293R-0.40815592
K291G293W-0.32043853
Q87S85L-0.21183868
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for UGP2 from PDB
PDB IDPDB titlePDB structure
3R2WCrystal Strucutre of UDP-glucose Pyrophosphorylase of Homo Sapiens

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Differential gene expression and gene-gene network for UGP2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of UGP2 and the right PPI network was created from samples without mutations in the LBS of UGP2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for UGP2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for UGP2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of UGP2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)4r7pCC181
ZNZINC(2+)4r7pDC181
UPGUDP-GLUCOSE4r7pAD253 K291
ZNZINC(2+)4r7pCQ87


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Conservation information for LBS of UGP2
Multiple alignments for Q16851 in multiple species
LBSAA sequence# speciesSpecies
C123GTSMGCKGPKS3Homo sapiens, Bos taurus, Mus musculus
C181QKYNHCRVKIY3Homo sapiens, Bos taurus, Mus musculus
D253FVSNIDNLGAT3Homo sapiens, Bos taurus, Mus musculus
E147TVQQIEHLNKT3Homo sapiens, Bos taurus, Mus musculus
G115VVKLNGGLGTS3Homo sapiens, Bos taurus, Mus musculus
G116VKLNGGLGTSM3Homo sapiens, Bos taurus, Mus musculus
G222AWYPPGHGDIY3Homo sapiens, Bos taurus, Mus musculus
H180LQKYNHCRVKI3Homo sapiens, Bos taurus, Mus musculus
H223WYPPGHGDIYA3Homo sapiens, Bos taurus, Mus musculus
H266LYILNHLMNPP3Homo sapiens, Bos taurus, Mus musculus
K291TRADVKGGTLT3Homo sapiens, Bos taurus, Mus musculus
L113LVVVKLNGGLG3Homo sapiens, Bos taurus, Mus musculus
N114VVVKLNGGLGT3Homo sapiens, Bos taurus, Mus musculus
N179ILQKYNHCRVK3Homo sapiens, Bos taurus, Mus musculus
N251YIFVSNIDNLG3Homo sapiens, Bos taurus, Mus musculus
N328KFKIFNTNNLW3Homo sapiens, Bos taurus, Mus musculus
N330KIFNTNNLWIS3Homo sapiens, Bos taurus, Mus musculus
P394RSRFLPVKTTS3Homo sapiens, Bos taurus, Mus musculus
Q190IYTFNQSRYPR3Homo sapiens, Bos taurus, Mus musculus
Q440SFTKVQDYLRR3Homo sapiens, Bos taurus, Mus musculus
Q87PEDSIQPYEKI3Homo sapiens, Bos taurus, Mus musculus


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