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mutLBSgeneDB |
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| Gene summary for UGP2 |
 Gene summary |
| Basic gene Info. | Gene symbol | UGP2 |
| Gene name | UDP-glucose pyrophosphorylase 2 | |
| Synonyms | UDPG|UDPGP|UDPGP2|UGP1|UGPP1|UGPP2|pHC379 | |
| Cytomap | UCSC genome browser: 2p14-p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001001521.1, NM_006759.3, | |
| Description | UDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferaseUTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1uridy | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 191760 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000169764 | ||
| HPRD : 08934 | ||
| Vega : OTTHUMG00000129513 | ||
| Protein | UniProt: Q16851 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_UGP2 | |
| BioGPS: 7360 | ||
| Pathway | NCI Pathway Interaction Database: UGP2 | |
| KEGG: UGP2 | ||
| REACTOME: UGP2 | ||
| Pathway Commons: UGP2 | ||
| Context | iHOP: UGP2 | |
| ligand binding site mutation search in PubMed: UGP2 | ||
| UCL Cancer Institute: UGP2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for UGP2 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D253 | D253H | BLCA | 2 | D253 | L255M | COAD | 1 | K291 | G293W | KIRC | 1 | Q87 | S85L | STAD | 1 | C181 | R182C | STAD | 1 | K291 | G293R | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for UGP2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C181 | R182C | -1.4732554 | D253 | L255M | -1.0464782 | D253 | D253H | -0.59184614 | K291 | G293R | -0.40815592 | K291 | G293W | -0.32043853 | Q87 | S85L | -0.21183868 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for UGP2 from PDB |
| PDB ID | PDB title | PDB structure | 3R2W | Crystal Strucutre of UDP-glucose Pyrophosphorylase of Homo Sapiens |  |
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| Differential gene expression and gene-gene network for UGP2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for UGP2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for UGP2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of UGP2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4r7p | C | C181 | ZN | ZINC(2+) | 4r7p | D | C181 | UPG | UDP-GLUCOSE | 4r7p | A | D253 K291 | ZN | ZINC(2+) | 4r7p | C | Q87 |
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| Conservation information for LBS of UGP2 |
| Multiple alignments for Q16851 in multiple species |
| LBS | AA sequence | # species | Species | C123 | GTSMGCKGPKS | 3 | Homo sapiens, Bos taurus, Mus musculus | C181 | QKYNHCRVKIY | 3 | Homo sapiens, Bos taurus, Mus musculus | D253 | FVSNIDNLGAT | 3 | Homo sapiens, Bos taurus, Mus musculus | E147 | TVQQIEHLNKT | 3 | Homo sapiens, Bos taurus, Mus musculus | G115 | VVKLNGGLGTS | 3 | Homo sapiens, Bos taurus, Mus musculus | G116 | VKLNGGLGTSM | 3 | Homo sapiens, Bos taurus, Mus musculus | G222 | AWYPPGHGDIY | 3 | Homo sapiens, Bos taurus, Mus musculus | H180 | LQKYNHCRVKI | 3 | Homo sapiens, Bos taurus, Mus musculus | H223 | WYPPGHGDIYA | 3 | Homo sapiens, Bos taurus, Mus musculus | H266 | LYILNHLMNPP | 3 | Homo sapiens, Bos taurus, Mus musculus | K291 | TRADVKGGTLT | 3 | Homo sapiens, Bos taurus, Mus musculus | L113 | LVVVKLNGGLG | 3 | Homo sapiens, Bos taurus, Mus musculus | N114 | VVVKLNGGLGT | 3 | Homo sapiens, Bos taurus, Mus musculus | N179 | ILQKYNHCRVK | 3 | Homo sapiens, Bos taurus, Mus musculus | N251 | YIFVSNIDNLG | 3 | Homo sapiens, Bos taurus, Mus musculus | N328 | KFKIFNTNNLW | 3 | Homo sapiens, Bos taurus, Mus musculus | N330 | KIFNTNNLWIS | 3 | Homo sapiens, Bos taurus, Mus musculus | P394 | RSRFLPVKTTS | 3 | Homo sapiens, Bos taurus, Mus musculus | Q190 | IYTFNQSRYPR | 3 | Homo sapiens, Bos taurus, Mus musculus | Q440 | SFTKVQDYLRR | 3 | Homo sapiens, Bos taurus, Mus musculus | Q87 | PEDSIQPYEKI | 3 | Homo sapiens, Bos taurus, Mus musculus |
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