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mutLBSgeneDB |
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| Gene summary for VAV2 |
 Gene summary |
| Basic gene Info. | Gene symbol | VAV2 |
| Gene name | vav 2 guanine nucleotide exchange factor | |
| Synonyms | VAV-2 | |
| Cytomap | UCSC genome browser: 9q34.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001134398.1, NM_003371.3, | |
| Description | guanine nucleotide exchange factor VAV2vav 2 oncogene | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600428 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000160293 | ||
| HPRD : 02694 | ||
| Vega : OTTHUMG00000020882 | ||
| Protein | UniProt: P52735 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_VAV2 | |
| BioGPS: 7410 | ||
| Pathway | NCI Pathway Interaction Database: VAV2 | |
| KEGG: VAV2 | ||
| REACTOME: VAV2 | ||
| Pathway Commons: VAV2 | ||
| Context | iHOP: VAV2 | |
| ligand binding site mutation search in PubMed: VAV2 | ||
| UCL Cancer Institute: VAV2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for VAV2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K718 | E716G | COAD | 3 | K718 | E716V | COAD | 2 | K718 | E716D | COAD | 2 | R700 | R700Q | COAD | 1 | L759 | D760N | COAD | 1 | R698 | R698M | OV | 1 | R700 | R700W | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for VAV2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K718 | E716G | -1.4692608 | R700 | R700Q | -1.4231702 | K718 | E716D | -1.2941696 | R700 | R700W | -1.1493934 | K718 | E716V | -0.94869178 | R698 | R698M | -0.52961524 | L759 | D760N | -0.42126632 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for VAV2 from PDB |
| PDB ID | PDB title | PDB structure | 2DLZ | Solution structure of the SH2 domain of human protein vav-2 |  |
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| Differential gene expression and gene-gene network for VAV2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for VAV2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for VAV2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of VAV2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (PRO,PRO,CYS,TYR,MET,ASP,VAL) | 4roj | C | R698 R700 | III | Peptide ligand (PRO,PRO,CYS,TYR,MET,ASP,VAL,ILE,NH2) | 4roj | A | R698 R700 K718 | III | Peptide ligand (PRO,PRO,CYS,TYR,MET,ASP,VAL) | 4roj | B | R698 R700 K718 | III | Peptide ligand (GLU,GLU,PRO,VAL,TYR,GLU,GLU,VAL,GLY) | 2lnw | A | R698 R700 K718 L759 |
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| Conservation information for LBS of VAV2 |
| Multiple alignments for P52735 in multiple species |
| LBS | AA sequence | # species | Species |
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