mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for VCP
Gene summary
Basic gene Info.Gene symbolVCP
Gene namevalosin containing protein
SynonymsALS14|HEL-220|HEL-S-70|IBMPFD|IBMPFD1|TERA|p97
CytomapUCSC genome browser: 9p13.3
Type of geneprotein-coding
RefGenesNM_007126.3,
Description15S Mg(2+)-ATPase p97 subunitTER ATPaseepididymis luminal protein 220epididymis secretory protein Li 70transitional endoplasmic reticulum ATPasevalosin-containing proteinyeast Cdc48p homolog
Modification date20141222
dbXrefs MIM : 601023
HGNC : HGNC
Ensembl : ENSG00000165280
HPRD : 03013
Vega : OTTHUMG00000019855
ProteinUniProt: P55072
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_VCP
BioGPS: 7415
PathwayNCI Pathway Interaction Database: VCP
KEGG: VCP
REACTOME: VCP
Pathway Commons: VCP
ContextiHOP: VCP
ligand binding site mutation search in PubMed: VCP
UCL Cancer Institute: VCP
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006302double-strand break repair10855792
GO:0006974cellular response to DNA damage stimulus16140914
GO:0016567protein ubiquitination22120668
GO:0030433ER-associated ubiquitin-dependent protein catabolic process17872946
GO:0030970retrograde protein transport, ER to cytosol15215856
GO:0031334positive regulation of protein complex assembly18775313
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process9452483
GO:0045732positive regulation of protein catabolic process11483959
GO:1903006positive regulation of protein K63-linked deubiquitination22970133
GO:1903007positive regulation of Lys63-specific deubiquitinase activity22970133


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Ligand binding site mutations for VCP

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R359R359QCOAD1
H183H183YLUAD1
I32E30KSKCM1
A142E141KSKCM1
I70V71IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for VCP
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R359R359Q-1.2118103
I70V71I-1.0262463
I32E30K-0.80003462
A142E141K-0.47845475
H183H183Y-0.41372603
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for VCP from PDB

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Differential gene expression and gene-gene network for VCP
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of VCP and the right PPI network was created from samples without mutations in the LBS of VCP. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for VCP
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1833662Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia31Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for VCP
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of VCP go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
COCOBALT(2+)3qq7AH183
IIIPeptide ligand (ARG,ALA,PHE,SER,GLY,SER,GLY,ASN,ARG,LEU)5c1bAH183
IIIPeptide ligand (PHE,ARG,ALA,PHE,SER,GLY,SER,GLY,ASN,ARG,LEU)5c1bDH183
IIIPeptide ligand (VAL,THR,LEU,ARG,ARG,ARG,MET,LEU,ALA,ALA,ALA,ALA,GLU,ARG,ARG,LEU,GLN,LYS,GLN)3tiwBI32 I70 A142
IIIPeptide ligand (VAL,THR,LEU,ARG,ARG,ARG,MET,LEU,ALA,ALA,ALA,ALA,GLU,ARG,ARG,LEU,GLN,LYS)3tiwAI70 A142
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu1AR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu1BR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu1CR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu1DR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu1ER359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu1FR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu2AR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu2BR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu2CR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu2DR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu2ER359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu2FR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3hu3BR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE4klnAR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE4klnBR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE4klnCR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE4klnDR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE4klnER359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE4klnFR359
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE4ko8BR359
ADPADP4kodBR359
ADPADP4kodCR359
ADPADP4kodFR359
ADPADP4kodHR359
ADPADP4kodJR359
ADPADP4kodLR359


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Conservation information for LBS of VCP
Multiple alignments for P55072 in multiple species
LBSAA sequence# speciesSpecies
A142PYFLEAYRPIR6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
A142PYFLEAYRPVR3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
A142PYFLEAYRPLH1Caenorhabditis elegans
A142PYFTDAYRPVH1Caenorhabditis elegans
A142PYFLEAYRPIH1Drosophila melanogaster
A142PYFVEAYRPVR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A142PYFVEAYRPIR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A409HGHVGADLAAL6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
A409HGYVGADLAAL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
A409HGFVGADLASL2Caenorhabditis elegans, Caenorhabditis elegans
A409HGHVGADLASL1Drosophila melanogaster
A409HGYVGADIASL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A409HGYVGSDLASL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D205EVGYDDIGGCR7Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D205EVGYDDVGGVR2Arabidopsis thaliana, Arabidopsis thaliana
D205DVGYDDVGGVR1Arabidopsis thaliana
D205DIGYDDLGGVR1Caenorhabditis elegans
D205EVGYDDLGGVR1Caenorhabditis elegans
D205AVGYDDIGGCR1Drosophila melanogaster
D205EVGYDDIGGVR1Danio rerio
D304AIIFIDELDAI6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
D304SIIFIDEIDSI3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
D304AILFIDEIDAI2Caenorhabditis elegans, Caenorhabditis elegans
D304AIIFIDEIDSI2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D304AIIFIDEIDAI1Drosophila melanogaster
D35EAINEDNSVVS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D35EAINDDNSVVS3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
D35ESINEDNSVVS2Danio rerio, Xenopus tropicalis
D35QSEQDDNSVIA1Caenorhabditis elegans
D35QSDNDDNSMVM1Caenorhabditis elegans
D35EAQNDDNSVVS1Drosophila melanogaster
D35DAINDDNSVIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D35DATNDDNSVIT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D55QLFRGDTVLLK6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
D55QLFRGDTILIK3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
D55GLFRGDAVILK1Caenorhabditis elegans
D55GLFRGDSVILK1Caenorhabditis elegans
D55QLFRGDTVILK1Drosophila melanogaster
D55ELFRGDTVLVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D55QLFRGDTVVVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E34DEAINEDNSVV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E34DEAINDDNSVV3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
E34DESINEDNSVV2Danio rerio, Xenopus tropicalis
E34DQSEQDDNSVI1Caenorhabditis elegans
E34DQSDNDDNSMV1Caenorhabditis elegans
E34EEAQNDDNSVV1Drosophila melanogaster
E34DDAINDDNSVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E34DDATNDDNSVI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F360PALRRFGRFDR12Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyc
F360GALRRFGRFDR2Caenorhabditis elegans, Caenorhabditis elegans
F52DELQLFRGDTV7Homo sapiens, Drosophila melanogaster, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
F52EKLQLFRGDTI3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
F52DELGLFRGDAV1Caenorhabditis elegans
F52DELGLFRGDSV1Caenorhabditis elegans
F52DKLELFRGDTV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F52ETLQLFRGDTV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G207GYDDIGGCRKQ7Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G207GYDDVGGVRKQ3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G207GYDDLGGVRKQ2Caenorhabditis elegans, Caenorhabditis elegans
G207GYDDIGGVRKQ1Danio rerio
G207GYDDIGGCRRQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G248LYGPPGTGKTL6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
G248LYGPPGSGKTL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G248MYGPPGTGKTL3Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G248LFGPPGTGKTL2Caenorhabditis elegans, Caenorhabditis elegans
G250GPPGTGKTLIA9Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
G250GPPGSGKTLIA3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G250GPPGTGKTLMA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G408THGHVGADLAA6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
G408THGYVGADLAA3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G408CHGFVGADLAS2Caenorhabditis elegans, Caenorhabditis elegans
G408SHGHVGADLAS1Drosophila melanogaster
G408THGYVGADIAS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G408THGYVGSDLAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G54LQLFRGDTVLL6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
G54LQLFRGDTILI3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G54LGLFRGDAVIL1Caenorhabditis elegans
G54LGLFRGDSVIL1Caenorhabditis elegans
G54LQLFRGDTVIL1Drosophila melanogaster
G54LELFRGDTVLV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G54LQLFRGDTVVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H183PDTVIHCEGEP6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
H183PDTEIFCEGEP3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
H183QDTIIHWEGEP2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H183PDTMIHYEGDP1Caenorhabditis elegans
H183PDTVIHYEGDP1Caenorhabditis elegans
H183PETVIFCDGDP1Drosophila melanogaster
H384EILQIHTKNMK6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
H384EVLRIHTKNMK5Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H384EILRIHTKNMK3Caenorhabditis elegans, Caenorhabditis elegans, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I175PSPYCIVAPDT6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
I175PAEYCVVAPDT3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
I175PAPACIVSPDT1Caenorhabditis elegans
I175PAPACIVAPDT1Caenorhabditis elegans
I175PEPYCIVAPET1Drosophila melanogaster
I175PEEYAVVAQDT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I175PDEFGIVSQDT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I206VGYDDIGGCRK7Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I206VGYDDVGGVRK3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
I206IGYDDLGGVRK1Caenorhabditis elegans
I206VGYDDLGGVRK1Caenorhabditis elegans
I206VGYDDIGGVRK1Danio rerio
I206VGYDDIGGCRR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I32IVDEAINEDNS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I32VVDEAINDDNS3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
I32IVDESINEDNS2Danio rerio, Xenopus tropicalis
I32IVDQSEQDDNS1Caenorhabditis elegans
I32IIDQSDNDDNS1Caenorhabditis elegans
I32IVEEAQNDDNS1Drosophila melanogaster
I32LVDDAINDDNS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I32VVDDATNDDNS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I380TGRLEILQIHT6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
I380IGRLEVLRIHT3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
I380VGRLEILRIHT2Caenorhabditis elegans, Caenorhabditis elegans
I380TGRLEVLRIHT2Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I380TGRLEILRIHT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I70REAVCIVLSDD5Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
I70KDTVCIALADE3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
I70KESVAIIVSDE1Caenorhabditis elegans
I70RETVSIVLNAD1Caenorhabditis elegans
I70KETVCIVLSDD1Drosophila melanogaster
I70RETVCIVLSDD1Danio rerio
I70KDTVLIVLIDD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I70KDTVLIVLTDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K251PPGTGKTLIAR9Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
K251PPGSGKTLIAR3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K251PPGTGKTLMAR2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L253GTGKTLIARAV9Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
L253GSGKTLIARAV3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
L253GTGKTLMARAV2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N33VDEAINEDNSV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N33VDEAINDDNSV3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
N33VDESINEDNSV2Danio rerio, Xenopus tropicalis
N33VDQSEQDDNSV1Caenorhabditis elegans
N33IDQSDNDDNSM1Caenorhabditis elegans
N33VEEAQNDDNSV1Drosophila melanogaster
N33VDDAINDDNSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N33VDDATNDDNSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N348VMAATNRPNSI8Homo sapiens, Drosophila melanogaster, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N348VMGATNRPNSI3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
N348VIAATNRPNSI3Caenorhabditis elegans, Caenorhabditis elegans, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P247LLYGPPGTGKT6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
P247LLYGPPGSGKT3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
P247LMYGPPGTGKT3Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P247LLFGPPGTGKT2Caenorhabditis elegans, Caenorhabditis elegans
R113VKYGKRIHVLP6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
R113VKYGKRVHILP2Arabidopsis thaliana, Arabidopsis thaliana
R113VKYGNRVHILP1Arabidopsis thaliana
R113LSYGTRIHVLP1Caenorhabditis elegans
R113LEYGKRVHVLP1Caenorhabditis elegans
R113VKYGKRVRILP1Drosophila melanogaster
R113IKYATRISVLP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R113IKYAERISVLP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R144FLEAYRPIRKG6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
R144FLEAYRPVRKG3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R144FLEAYRPLHKG1Caenorhabditis elegans
R144FTDAYRPVHKG1Caenorhabditis elegans
R144FLEAYRPIHMG1Drosophila melanogaster
R144FVEAYRPVRKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R144FVEAYRPIRKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R359DPALRRFGRFD12Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyc
R359DGALRRFGRFD2Caenorhabditis elegans, Caenorhabditis elegans
R53ELQLFRGDTVL6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
R53KLQLFRGDTIL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R53ELGLFRGDAVI1Caenorhabditis elegans
R53ELGLFRGDSVI1Caenorhabditis elegans
R53ELQLFRGDTVI1Drosophila melanogaster
R53KLELFRGDTVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R53TLQLFRGDTVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T249YGPPGTGKTLI7Homo sapiens, Drosophila melanogaster, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
T249YGPPGSGKTLI3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T249FGPPGTGKTLI2Caenorhabditis elegans, Caenorhabditis elegans
T249YGPPGTGKTLM2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T252PGTGKTLIARA9Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
T252PGSGKTLIARA3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T252PGTGKTLMARA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T56LFRGDTVLLKG6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
T56LFRGDTILIKG3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T56LFRGDAVILKG1Caenorhabditis elegans
T56LFRGDSVILKG1Caenorhabditis elegans
T56LFRGDTVILKG1Drosophila melanogaster
T56LFRGDTVLVKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T56LFRGDTVVVKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V108QPCPDVKYGKR6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
V108HQCPDVKYGKR2Arabidopsis thaliana, Arabidopsis thaliana
V108HQCPDVKYGNR1Arabidopsis thaliana
V108TPAPNLSYGTR1Caenorhabditis elegans
V108SSA-QLEYGKR1Caenorhabditis elegans
V108QSCPDVKYGKR1Drosophila melanogaster
V108HPCPDIKYATR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V108NPCPDIKYAER1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V38NEDNSVVSLSQ6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
V38NDDNSVVSLHP3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
V38QDDNSVIAVSQ1Caenorhabditis elegans
V38NDDNSMVMLSQ1Caenorhabditis elegans
V38NDDNSVVSLSQ1Drosophila melanogaster
V38NDDNSVIAINS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V38NDDNSVITLSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y110CPDVKYGKRIH6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
Y110CPDVKYGKRVH2Arabidopsis thaliana, Arabidopsis thaliana
Y110CPDVKYGNRVH1Arabidopsis thaliana
Y110APNLSYGTRIH1Caenorhabditis elegans
Y110A-QLEYGKRVH1Caenorhabditis elegans
Y110CPDVKYGKRVR1Drosophila melanogaster
Y110CPDIKYATRIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y110CPDIKYAERIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y143YFLEAYRPIRK6Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
Y143YFLEAYRPVRK3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
Y143YFLEAYRPLHK1Caenorhabditis elegans
Y143YFTDAYRPVHK1Caenorhabditis elegans
Y143YFLEAYRPIHM1Drosophila melanogaster
Y143YFVEAYRPVRK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y143YFVEAYRPIRK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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