mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for WARS
Gene summary
Basic gene Info.Gene symbolWARS
Gene nametryptophanyl-tRNA synthetase
CytomapUCSC genome browser: 14q32.31
Type of geneprotein-coding
DescriptionhWRSinterferon-induced protein 53trpRStryptophan tRNA ligase 1, cytoplasmictryptophan--tRNA ligase, cytoplasmic
Modification date20141207
dbXrefs MIM : 191050
Ensembl : ENSG00000140105
HPRD : 01845
Vega : OTTHUMG00000171572
ProteinUniProt: P23381
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_WARS
BioGPS: 7453
PathwayNCI Pathway Interaction Database: WARS
Pathway Commons: WARS
ContextiHOP: WARS
ligand binding site mutation search in PubMed: WARS
UCL Cancer Institute: WARS
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0045765regulation of angiogenesis11773625

Ligand binding site mutations for WARS

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for WARS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for WARS from PDB
PDB IDPDB titlePDB structure
1r6tcrystal structure of human tryptophanyl-tRNA synthetase

Differential gene expression and gene-gene network for WARS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of WARS and the right PPI network was created from samples without mutations in the LBS of WARS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for WARS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for WARS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00150L-TryptophanSmall molecule
ExperimentalDB01831Tryptophanyl-5'ampSmall molecule
ExperimentalDB04537L-TryptophanamideSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of WARS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids2akeAG428
NUCNucleic Acids2azxAG428
NUCNucleic Acids2azxBG428
NUCNucleic Acids2dr2AG428
ATPATP2quiAR162 S353

Conservation information for LBS of WARS
Multiple alignments for P23381 in multiple species
LBSAA sequence# speciesSpecies
A168GPSSEAMHVGH2Homo sapiens, Bos taurus
A168GPSSDSMHLGH2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A168GPSSEAMHLGH1Mus musculus
A310CLIPCAIDQDP5Homo sapiens, Mus musculus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A352QTKMSASDPNS3Homo sapiens, Mus musculus, Bos taurus
A352TTKMSASDDTT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A352QSKMSASKDSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A376KVNKHAFSGGR3Homo sapiens, Mus musculus, Bos taurus
A376KINKYAFSGGQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A376KINRHAFSGGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C309QCLIPCAIDQD3Homo sapiens, Mus musculus, Bos taurus
C309PCLIPCAIDQD2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D312IPCAIDQDPYF5Homo sapiens, Mus musculus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D354KMSASDPNSSI3Homo sapiens, Mus musculus, Bos taurus
D354KMSASDDTTAI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D354KMSASKDSSAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D382FSGGRDTVEEH2Mus musculus, Bos taurus
D382FSGGRDTIEEH1Homo sapiens
D382FSGGQVSADLH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D382FSGGGATIEIH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E199QMTDDEKYLWK2Homo sapiens, Bos taurus
E199QMSDDEKYLWK1Mus musculus
E199ELTDDEKFLFK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E199QLTDDEKFLFK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E408LTFFLEDDDKL2Homo sapiens, Bos taurus
E408LTFFLEDDDRL1Mus musculus
E408LSFFKDDDVFL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E408LSFFLDDDEKL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F317DQDPYFRMTRD3Homo sapiens, Mus musculus, Bos taurus
F317DQDPYFRVCRD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F317DQDPYFRLTRD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F339LLHSTFFPALQ3Homo sapiens, Mus musculus, Bos taurus
F339LLHSRFFPALQ2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F340LHSTFFPALQG3Homo sapiens, Mus musculus, Bos taurus
F340LHSRFFPALQG2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F377VNKHAFSGGRD3Homo sapiens, Mus musculus, Bos taurus
F377INKYAFSGGQV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F377INRHAFSGGGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F406MYLTFFLEDDD3Homo sapiens, Mus musculus, Bos taurus
F406QYLSFFKDDDV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F406QYLSFFLDDDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G161FYLYTGRGPSS4Homo sapiens, Mus musculus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G161FFLYTGRGPSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G163LYTGRGPSSEA3Homo sapiens, Mus musculus, Bos taurus
G163LYTGRGPSSDS2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G172EAMHVGHLIPF2Homo sapiens, Bos taurus
G172DSMHLGHMIPF2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G172EAMHLGHLVPF1Mus musculus
G380HAFSGGRDTVE2Mus musculus, Bos taurus
G380HAFSGGRDTIE1Homo sapiens
G380YAFSGGQVSAD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G380HAFSGGGATIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G428GAMLTGELKKA1Homo sapiens
G428GAMLTGELKKT1Mus musculus
G428GAMLTGELKKE1Bos taurus
G428GELLSGEMKKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G428GTLSTGEMKGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H170SSEAMHVGHLI2Homo sapiens, Bos taurus
H170SSDSMHLGHMI2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H170SSEAMHLGHLV1Mus musculus
H173AMHVGHLIPFI2Homo sapiens, Bos taurus
H173AMHLGHLVPFI1Mus musculus
H173SMHLGHMIPFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H173SMHLGHMIPFM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H375TKVNKHAFSGG2Homo sapiens, Bos taurus
H375SKVNKHAFSGG1Mus musculus
H375KKINKYAFSGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H375NKINRHAFSGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H387DTVEEHRQFGG2Mus musculus, Bos taurus
H387DTIEEHRQFGG1Homo sapiens
H387VSADLHRELGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H387ATIEIHREKGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I175HVGHLIPFIFT2Homo sapiens, Bos taurus
I175HLGHLVPFIFT1Mus musculus
I175HLGHMIPFVFT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I175HLGHMIPFMFC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I178HLIPFIFTKWL2Homo sapiens, Bos taurus
I178HLVPFIFTKWL1Mus musculus
I178HMIPFVFTKWL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I178HMIPFMFCKWL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I307DIQCLIPCAID2Homo sapiens, Mus musculus
I307DVQCLIPCAID1Bos taurus
I307KTPCLIPCAID1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I307DIPCLIPCAID1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I384GGRDTVEEHRQ2Mus musculus, Bos taurus
I384GGRDTIEEHRQ1Homo sapiens
I384GGQVSADLHRE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I384GGGATIEIHRE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I442VLQPLIAEHQA3Homo sapiens, Mus musculus, Bos taurus
I442TLQEFVKAFQE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I442LLQQFVSDFQA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K200MTDDEKYLWKD2Homo sapiens, Bos taurus
K200MSDDEKYLWKD1Mus musculus
K200LTDDEKFLFKH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K200LTDDEKFLFKQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K349QGAQTKMSASD3Homo sapiens, Mus musculus, Bos taurus
K349QGSTTKMSASD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K349QGPQSKMSASK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K374KTKVNKHAFSG2Homo sapiens, Bos taurus
K374KSKVNKHAFSG1Mus musculus
K374QKKINKYAFSG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K374KNKINRHAFSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K431LTGELKKALIE1Homo sapiens
K431LTGELKKTLID1Mus musculus
K431LTGELKKELIE1Bos taurus
K431LSGEMKKLCIE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K431STGEMKGECIK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L174MHVGHLIPFIF2Homo sapiens, Bos taurus
L174MHLGHLVPFIF1Mus musculus
L174MHLGHMIPFVF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L174MHLGHMIPFMF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L426TSGAMLTGELK3Homo sapiens, Mus musculus, Bos taurus
L426KSGELLSGEMK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L426KAGTLSTGEMK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L441EVLQPLIAEHQ2Homo sapiens, Bos taurus
L441DVLQPLIAEHQ1Mus musculus
L441ETLQEFVKAFQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L441KLLQQFVSDFQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M350GAQTKMSASDP3Homo sapiens, Mus musculus, Bos taurus
M350GSTTKMSASDD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M350GPQSKMSASKD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N356SASDPNSSIFL3Homo sapiens, Mus musculus, Bos taurus
N356SASDDTTAIFM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N356SASKDSSAIFM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N373IKTKVNKHAFS2Homo sapiens, Bos taurus
N373IKSKVNKHAFS1Mus musculus
N373IQKKINKYAFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N373IKNKINRHAFS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P176VGHLIPFIFTK2Homo sapiens, Bos taurus
P176LGHLVPFIFTK1Mus musculus
P176LGHMIPFVFTK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P176LGHMIPFMFCK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P355MSASDPNSSIF3Homo sapiens, Mus musculus, Bos taurus
P355MSASDDTTAIF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P355MSASKDSSAIF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q194VPLVIQMTDDE2Homo sapiens, Bos taurus
Q194VPLVIQMSDDE1Mus musculus
Q194VPLVIELTDDE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q194VPLVIQLTDDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q284SFPAIQAAPSF2Homo sapiens, Bos taurus
Q284SFPAVQAAPSF1Mus musculus
Q284HFASIQIATAF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q284HFASIQAAPSF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q313PCAIDQDPYFR5Homo sapiens, Mus musculus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R162YLYTGRGPSSE3Homo sapiens, Mus musculus, Bos taurus
R162FLYTGRGPSSD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R162YLYTGRGPSSD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R381AFSGGRDTVEE2Mus musculus, Bos taurus
R381AFSGGRDTIEE1Homo sapiens
R381AFSGGQVSADL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R381AFSGGGATIEI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R448AEHQARRKEVT2Homo sapiens, Bos taurus
R448AEHQARRKAVT1Mus musculus
R448KAFQERRAQVD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R448SDFQAARSKVD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S165TGRGPSSEAMH3Homo sapiens, Mus musculus, Bos taurus
S165TGRGPSSDSMH2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S272FGFTDSDCIGK3Homo sapiens, Mus musculus, Bos taurus
S272FGFNDSDCIGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S272FGFTDSDSIGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S351AQTKMSASDPN3Homo sapiens, Mus musculus, Bos taurus
S351STTKMSASDDT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S351PQSKMSASKDS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S353TKMSASDPNSS3Homo sapiens, Mus musculus, Bos taurus
S353TKMSASDDTTA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S353SKMSASKDSSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S357ASDPNSSIFLT3Homo sapiens, Mus musculus, Bos taurus
S357ASDDTTAIFMT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S357ASKDSSAIFMT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S358SDPNSSIFLTD3Homo sapiens, Mus musculus, Bos taurus
S358SDDTTAIFMTD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S358SKDSSAIFMTD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S378NKHAFSGGRDT3Homo sapiens, Mus musculus, Bos taurus
S378NKYAFSGGQVS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S378NRHAFSGGGAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T160PFYLYTGRGPS4Homo sapiens, Mus musculus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T160PFFLYTGRGPS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T196LVIQMTDDEKY2Homo sapiens, Bos taurus
T196LVIQMSDDEKY1Mus musculus
T196LVIELTDDEKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T196LVIQLTDDEKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T383SGGRDTVEEHR2Mus musculus, Bos taurus
T383SGGRDTIEEHR1Homo sapiens
T383SGGQVSADLHR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T383SGGGATIEIHR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T427SGAMLTGELKK3Homo sapiens, Mus musculus, Bos taurus
T427SGELLSGEMKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T427AGTLSTGEMKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W88DFVDPWTVQT-2Homo sapiens, Bos taurus
W88DFVDPWTVRT-1Mus musculus
W88QVVTPWDVEGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W88QIVTPWDVKGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y159KPFYLYTGRGP4Homo sapiens, Mus musculus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y159KPFFLYTGRGP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

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