mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for WARS

Gene summary

Basic gene Info.	Gene symbol	WARS
	Gene name	tryptophanyl-tRNA synthetase
	Synonyms	GAMMA-2\|IFI53\|IFP53
	Cytomap	UCSC genome browser: 14q32.31
	Type of gene	protein-coding
	RefGenes	NM_004184.3, NM_173701.1,NM_213645.1,NM_213646.1,
	Description	hWRSinterferon-induced protein 53trpRStryptophan tRNA ligase 1, cytoplasmictryptophan--tRNA ligase, cytoplasmic
	Modification date	20141207
dbXrefs	MIM : 191050
	HGNC : HGNC
	Ensembl : ENSG00000140105
	HPRD : 01845
	Vega : OTTHUMG00000171572
Protein	UniProt: P23381 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_WARS
	BioGPS: 7453
Pathway	NCI Pathway Interaction Database: WARS
	KEGG: WARS
	REACTOME: WARS
	Pathway Commons: WARS
Context	iHOP: WARS
	ligand binding site mutation search in PubMed: WARS
	UCL Cancer Institute: WARS
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0045765	regulation of angiogenesis	11773625

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Ligand binding site mutations for WARS

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
G428	G428S	STAD	2
I178	T180K	COAD	1
Y159	L158V	LUAD	1
S353	S353I	LUSC	1
R162	R162W	UCEC	1
I175	I175V	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for WARS

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
G428	G428S	0.1879308
I175	I175V	-1.5262412
Y159	L158V	-1.3389976
I178	T180K	-1.1166865
R162	R162W	-0.67812372
S353	S353I	-0.57114221

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for WARS from PDB

PDB ID	PDB title	PDB structure
1r6t	crystal structure of human tryptophanyl-tRNA synthetase

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Differential gene expression and gene-gene network for WARS

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of WARS and the right PPI network was created from samples without mutations in the LBS of WARS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for WARS

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for WARS

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved\|nutraceutical	DB00150	L-Tryptophan	Small molecule
Experimental	DB01831	Tryptophanyl-5'amp	Small molecule
Experimental	DB04537	L-Tryptophanamide	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of WARS go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
NUC		Nucleic Acids	2ake	A	G428
NUC		Nucleic Acids	2azx	A	G428
NUC		Nucleic Acids	2azx	B	G428
NUC		Nucleic Acids	2dr2	A	G428
TRP		L-TRYPTOPHAN	2azx	A	I178
ATP		ATP	2qui	A	R162 S353
TYM		TRYPTOPHANYL-5'AMP	1r6t	A	Y159 R162
TYM		TRYPTOPHANYL-5'AMP	1r6u	A	Y159 R162
TRP		L-TRYPTOPHAN	2ake	A	Y159 R162
TRP		L-TRYPTOPHAN	2azx	A	Y159 R162
TRP		L-TRYPTOPHAN	2azx	B	Y159 R162
TRP		L-TRYPTOPHAN	2dr2	A	Y159 R162
TRP		L-TRYPTOPHAN	2quh	A	Y159 R162
TRP		L-TRYPTOPHAN	2quh	B	Y159 R162
LTN		L-TRYPTOPHANAMIDE	2qui	A	Y159 R162
LTN		L-TRYPTOPHANAMIDE	2qui	B	Y159 R162
TRP		L-TRYPTOPHAN	2quj	B	Y159 R162
TYM		TRYPTOPHANYL-5'AMP	2quj	A	Y159 R162 I175

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Conservation information for LBS of WARS

Multiple alignments for P23381 in multiple species

LBS	AA sequence	# species	Species
A168	GPSSEAMHVGH	2	Homo sapiens, Bos taurus
A168	GPSSDSMHLGH	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A168	GPSSEAMHLGH	1	Mus musculus
A310	CLIPCAIDQDP	5	Homo sapiens, Mus musculus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A352	QTKMSASDPNS	3	Homo sapiens, Mus musculus, Bos taurus
A352	TTKMSASDDTT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A352	QSKMSASKDSS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A376	KVNKHAFSGGR	3	Homo sapiens, Mus musculus, Bos taurus
A376	KINKYAFSGGQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A376	KINRHAFSGGG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C309	QCLIPCAIDQD	3	Homo sapiens, Mus musculus, Bos taurus
C309	PCLIPCAIDQD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D312	IPCAIDQDPYF	5	Homo sapiens, Mus musculus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D354	KMSASDPNSSI	3	Homo sapiens, Mus musculus, Bos taurus
D354	KMSASDDTTAI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D354	KMSASKDSSAI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D382	FSGGRDTVEEH	2	Mus musculus, Bos taurus
D382	FSGGRDTIEEH	1	Homo sapiens
D382	FSGGQVSADLH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D382	FSGGGATIEIH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E199	QMTDDEKYLWK	2	Homo sapiens, Bos taurus
E199	QMSDDEKYLWK	1	Mus musculus
E199	ELTDDEKFLFK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E199	QLTDDEKFLFK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E408	LTFFLEDDDKL	2	Homo sapiens, Bos taurus
E408	LTFFLEDDDRL	1	Mus musculus
E408	LSFFKDDDVFL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E408	LSFFLDDDEKL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F317	DQDPYFRMTRD	3	Homo sapiens, Mus musculus, Bos taurus
F317	DQDPYFRVCRD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F317	DQDPYFRLTRD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F339	LLHSTFFPALQ	3	Homo sapiens, Mus musculus, Bos taurus
F339	LLHSRFFPALQ	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F340	LHSTFFPALQG	3	Homo sapiens, Mus musculus, Bos taurus
F340	LHSRFFPALQG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F377	VNKHAFSGGRD	3	Homo sapiens, Mus musculus, Bos taurus
F377	INKYAFSGGQV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F377	INRHAFSGGGA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F406	MYLTFFLEDDD	3	Homo sapiens, Mus musculus, Bos taurus
F406	QYLSFFKDDDV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F406	QYLSFFLDDDE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G161	FYLYTGRGPSS	4	Homo sapiens, Mus musculus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G161	FFLYTGRGPSS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G163	LYTGRGPSSEA	3	Homo sapiens, Mus musculus, Bos taurus
G163	LYTGRGPSSDS	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G172	EAMHVGHLIPF	2	Homo sapiens, Bos taurus
G172	DSMHLGHMIPF	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G172	EAMHLGHLVPF	1	Mus musculus
G380	HAFSGGRDTVE	2	Mus musculus, Bos taurus
G380	HAFSGGRDTIE	1	Homo sapiens
G380	YAFSGGQVSAD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G380	HAFSGGGATIE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G428	GAMLTGELKKA	1	Homo sapiens
G428	GAMLTGELKKT	1	Mus musculus
G428	GAMLTGELKKE	1	Bos taurus
G428	GELLSGEMKKL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G428	GTLSTGEMKGE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H170	SSEAMHVGHLI	2	Homo sapiens, Bos taurus
H170	SSDSMHLGHMI	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H170	SSEAMHLGHLV	1	Mus musculus
H173	AMHVGHLIPFI	2	Homo sapiens, Bos taurus
H173	AMHLGHLVPFI	1	Mus musculus
H173	SMHLGHMIPFV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H173	SMHLGHMIPFM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H375	TKVNKHAFSGG	2	Homo sapiens, Bos taurus
H375	SKVNKHAFSGG	1	Mus musculus
H375	KKINKYAFSGG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H375	NKINRHAFSGG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H387	DTVEEHRQFGG	2	Mus musculus, Bos taurus
H387	DTIEEHRQFGG	1	Homo sapiens
H387	VSADLHRELGG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H387	ATIEIHREKGG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I175	HVGHLIPFIFT	2	Homo sapiens, Bos taurus
I175	HLGHLVPFIFT	1	Mus musculus
I175	HLGHMIPFVFT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I175	HLGHMIPFMFC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I178	HLIPFIFTKWL	2	Homo sapiens, Bos taurus
I178	HLVPFIFTKWL	1	Mus musculus
I178	HMIPFVFTKWL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I178	HMIPFMFCKWL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I307	DIQCLIPCAID	2	Homo sapiens, Mus musculus
I307	DVQCLIPCAID	1	Bos taurus
I307	KTPCLIPCAID	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I307	DIPCLIPCAID	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I384	GGRDTVEEHRQ	2	Mus musculus, Bos taurus
I384	GGRDTIEEHRQ	1	Homo sapiens
I384	GGQVSADLHRE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I384	GGGATIEIHRE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I442	VLQPLIAEHQA	3	Homo sapiens, Mus musculus, Bos taurus
I442	TLQEFVKAFQE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I442	LLQQFVSDFQA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K200	MTDDEKYLWKD	2	Homo sapiens, Bos taurus
K200	MSDDEKYLWKD	1	Mus musculus
K200	LTDDEKFLFKH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K200	LTDDEKFLFKQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K349	QGAQTKMSASD	3	Homo sapiens, Mus musculus, Bos taurus
K349	QGSTTKMSASD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K349	QGPQSKMSASK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K374	KTKVNKHAFSG	2	Homo sapiens, Bos taurus
K374	KSKVNKHAFSG	1	Mus musculus
K374	QKKINKYAFSG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K374	KNKINRHAFSG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K431	LTGELKKALIE	1	Homo sapiens
K431	LTGELKKTLID	1	Mus musculus
K431	LTGELKKELIE	1	Bos taurus
K431	LSGEMKKLCIE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K431	STGEMKGECIK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L174	MHVGHLIPFIF	2	Homo sapiens, Bos taurus
L174	MHLGHLVPFIF	1	Mus musculus
L174	MHLGHMIPFVF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L174	MHLGHMIPFMF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L426	TSGAMLTGELK	3	Homo sapiens, Mus musculus, Bos taurus
L426	KSGELLSGEMK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L426	KAGTLSTGEMK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L441	EVLQPLIAEHQ	2	Homo sapiens, Bos taurus
L441	DVLQPLIAEHQ	1	Mus musculus
L441	ETLQEFVKAFQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L441	KLLQQFVSDFQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M350	GAQTKMSASDP	3	Homo sapiens, Mus musculus, Bos taurus
M350	GSTTKMSASDD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M350	GPQSKMSASKD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N356	SASDPNSSIFL	3	Homo sapiens, Mus musculus, Bos taurus
N356	SASDDTTAIFM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N356	SASKDSSAIFM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N373	IKTKVNKHAFS	2	Homo sapiens, Bos taurus
N373	IKSKVNKHAFS	1	Mus musculus
N373	IQKKINKYAFS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N373	IKNKINRHAFS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P176	VGHLIPFIFTK	2	Homo sapiens, Bos taurus
P176	LGHLVPFIFTK	1	Mus musculus
P176	LGHMIPFVFTK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P176	LGHMIPFMFCK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P355	MSASDPNSSIF	3	Homo sapiens, Mus musculus, Bos taurus
P355	MSASDDTTAIF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P355	MSASKDSSAIF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q194	VPLVIQMTDDE	2	Homo sapiens, Bos taurus
Q194	VPLVIQMSDDE	1	Mus musculus
Q194	VPLVIELTDDE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q194	VPLVIQLTDDE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q284	SFPAIQAAPSF	2	Homo sapiens, Bos taurus
Q284	SFPAVQAAPSF	1	Mus musculus
Q284	HFASIQIATAF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q284	HFASIQAAPSF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q313	PCAIDQDPYFR	5	Homo sapiens, Mus musculus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R162	YLYTGRGPSSE	3	Homo sapiens, Mus musculus, Bos taurus
R162	FLYTGRGPSSD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R162	YLYTGRGPSSD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R381	AFSGGRDTVEE	2	Mus musculus, Bos taurus
R381	AFSGGRDTIEE	1	Homo sapiens
R381	AFSGGQVSADL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R381	AFSGGGATIEI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R448	AEHQARRKEVT	2	Homo sapiens, Bos taurus
R448	AEHQARRKAVT	1	Mus musculus
R448	KAFQERRAQVD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R448	SDFQAARSKVD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S165	TGRGPSSEAMH	3	Homo sapiens, Mus musculus, Bos taurus
S165	TGRGPSSDSMH	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S272	FGFTDSDCIGK	3	Homo sapiens, Mus musculus, Bos taurus
S272	FGFNDSDCIGK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S272	FGFTDSDSIGK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S351	AQTKMSASDPN	3	Homo sapiens, Mus musculus, Bos taurus
S351	STTKMSASDDT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S351	PQSKMSASKDS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S353	TKMSASDPNSS	3	Homo sapiens, Mus musculus, Bos taurus
S353	TKMSASDDTTA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S353	SKMSASKDSSA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S357	ASDPNSSIFLT	3	Homo sapiens, Mus musculus, Bos taurus
S357	ASDDTTAIFMT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S357	ASKDSSAIFMT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S358	SDPNSSIFLTD	3	Homo sapiens, Mus musculus, Bos taurus
S358	SDDTTAIFMTD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S358	SKDSSAIFMTD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S378	NKHAFSGGRDT	3	Homo sapiens, Mus musculus, Bos taurus
S378	NKYAFSGGQVS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S378	NRHAFSGGGAT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T160	PFYLYTGRGPS	4	Homo sapiens, Mus musculus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T160	PFFLYTGRGPS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T196	LVIQMTDDEKY	2	Homo sapiens, Bos taurus
T196	LVIQMSDDEKY	1	Mus musculus
T196	LVIELTDDEKF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T196	LVIQLTDDEKF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T383	SGGRDTVEEHR	2	Mus musculus, Bos taurus
T383	SGGRDTIEEHR	1	Homo sapiens
T383	SGGQVSADLHR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T383	SGGGATIEIHR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T427	SGAMLTGELKK	3	Homo sapiens, Mus musculus, Bos taurus
T427	SGELLSGEMKK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T427	AGTLSTGEMKG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W88	DFVDPWTVQT-	2	Homo sapiens, Bos taurus
W88	DFVDPWTVRT-	1	Mus musculus
W88	QVVTPWDVEGG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W88	QIVTPWDVKGS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y159	KPFYLYTGRGP	4	Homo sapiens, Mus musculus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y159	KPFFLYTGRGP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)