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mutLBSgeneDB |
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| Gene summary for WEE1 |
 Gene summary |
| Basic gene Info. | Gene symbol | WEE1 |
| Gene name | WEE1 G2 checkpoint kinase | |
| Synonyms | WEE1A|WEE1hu | |
| Cytomap | UCSC genome browser: 11p15.4 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001143976.1, NM_003390.3, | |
| Description | WEE1 homologWEE1+ homologwee1-like protein kinasewee1A kinase | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 193525 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166483 | ||
| HPRD : 01907 | ||
| Vega : OTTHUMG00000165863 | ||
| Protein | UniProt: P30291 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_WEE1 | |
| BioGPS: 7465 | ||
| Pathway | NCI Pathway Interaction Database: WEE1 | |
| KEGG: WEE1 | ||
| REACTOME: WEE1 | ||
| Pathway Commons: WEE1 | ||
| Context | iHOP: WEE1 | |
| ligand binding site mutation search in PubMed: WEE1 | ||
| UCL Cancer Institute: WEE1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for WEE1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V360 | R361L | COAD | 2 | N342 | A343T | COAD | 1 | V360 | V360F | HNSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for WEE1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V360 | R361L | -0.78838657 | V360 | V360F | -0.60012045 | N342 | A343T | -0.29395496 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for WEE1 from PDB |
| PDB ID | PDB title | PDB structure | 3CQE | Wee1 kinase complex with inhibitor PD074291 |  |
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| Differential gene expression and gene-gene network for WEE1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for WEE1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for WEE1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB04608 | 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE | Small molecule |  |
| Experimental | DB07006 | 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE | Small molecule |  |
| Experimental | DB07226 | N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE | Small molecule |  |
| Experimental | DB07257 | 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione | Small molecule |  |
| Experimental | DB07265 | 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID | Small molecule |  |
| Experimental | DB08365 | 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of WEE1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 1x8b | A | N342 | 824 | 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE | 1x8b | A | V360 | 839 | 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID | 2in6 | A | V360 | 330 | 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE | 2io6 | A | V360 | 770 | N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE | 2z2w | A | V360 | 396 | 4-(2-CHLOROPHENYL)-9-HYDROXY-6-METHYL-1,3-DIOXO-N-(2-PYRROLIDIN-1-YLETHYL)PYRROLO[3,4-G]CARBAZOLE-8-CARBOXAMIDE | 3bi6 | A | V360 | 61E | 4-(2-CHLOROPHENYL)-8-[3-(DIMETHYLAMINO)PROPOXY]-9-HYDROXY-6-METHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE | 3biz | A | V360 | P91 | 8-BROMO-4-(2-CHLOROPHENYL)-N-(2-HYDROXYETHYL)-6-METHYL-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-E]INDOLE-7-CARBOXAMIDE | 3cqe | A | V360 | 809 | 4-(2-CHLOROPHENYL)-8-(2-HYDROXYETHYL)-6-METHYLPYRROLO[3,4-E]INDOLE-1,3(2H,6H)-DIONE | 3cr0 | A | V360 |
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| Conservation information for LBS of WEE1 |
| Multiple alignments for P30291 in multiple species |
| LBS | AA sequence | # species | Species | A326 | DGCIYAIKRSK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A326 | DGCIYAIKKSK | 1 | Drosophila melanogaster | C379 | IQNEYCNGGSL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C379 | IQNEFCDGGSL | 1 | Drosophila melanogaster | D386 | GGSLADAISEN | 2 | Homo sapiens, Mus musculus | D386 | GGSLHARIQDH | 1 | Drosophila melanogaster | D386 | GGSLADAVSEN | 1 | Rattus norvegicus | D463 | MFKIGDLGHVT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D463 | TYKIGDLGHVT | 1 | Drosophila melanogaster | E303 | EFHELEKIGSG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E303 | EFMQVNVIGVG | 1 | Drosophila melanogaster | E346 | QNALREVYAHA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E346 | KRALNEVWAHA | 1 | Drosophila melanogaster | E377 | MLIQNEYCNGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E377 | MLIQNEFCDGG | 1 | Drosophila melanogaster | G306 | ELEKIGSGEFG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G306 | QVNVIGVGEFG | 1 | Drosophila melanogaster | G381 | NEYCNGGSLAD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G381 | NEFCDGGSLHA | 1 | Drosophila melanogaster | G382 | EYCNGGSLADA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G382 | EFCDGGSLHAR | 1 | Drosophila melanogaster | G465 | KIGDLGHVTRI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G465 | KIGDLGHVTSV | 1 | Drosophila melanogaster | I305 | HELEKIGSGEF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I305 | MQVNVIGVGEF | 1 | Drosophila melanogaster | I374 | DDHMLIQNEYC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I374 | DDHMLIQNEFC | 1 | Drosophila melanogaster | K328 | CIYAIKRSKKP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K328 | CIYAIKKSKKP | 1 | Drosophila melanogaster | N342 | SVDEQNALREV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N342 | SSFEKRALNEV | 1 | Drosophila melanogaster | N376 | HMLIQNEYCNG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N376 | HMLIQNEFCDG | 1 | Drosophila melanogaster | N380 | QNEYCNGGSLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N380 | QNEFCDGGSLH | 1 | Drosophila melanogaster | N431 | DIKPSNIFISR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N431 | DLKPENIFSTM | 1 | Drosophila melanogaster | R345 | EQNALREVYAH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R345 | EKRALNEVWAH | 1 | Drosophila melanogaster | S383 | YCNGGSLADAI | 2 | Homo sapiens, Mus musculus | S383 | FCDGGSLHARI | 1 | Drosophila melanogaster | S383 | YCNGGSLADAV | 1 | Rattus norvegicus | S430 | MDIKPSNIFIS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S430 | MDLKPENIFST | 1 | Drosophila melanogaster | V313 | GEFGSVFKCVK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V313 | GEFGVVFQCVN | 1 | Drosophila melanogaster | V360 | QHPHVVRYFSA | 2 | Mus musculus, Rattus norvegicus | V360 | QHSHVVRYFSA | 1 | Homo sapiens | V360 | KHDNVVRYYSA | 1 | Drosophila melanogaster | Y378 | LIQNEYCNGGS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y378 | LIQNEFCDGGS | 1 | Drosophila melanogaster |
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