mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for XDH
Gene summary
Basic gene Info.Gene symbolXDH
Gene namexanthine dehydrogenase
SynonymsXO|XOR
CytomapUCSC genome browser: 2p23.1
Type of geneprotein-coding
RefGenesNM_000379.3,
Descriptionxanthine dehydrogenase/oxidasexanthine oxidoreductase
Modification date20141207
dbXrefs MIM : 607633
HGNC : HGNC
Ensembl : ENSG00000158125
HPRD : 06363
Vega : OTTHUMG00000099385
ProteinUniProt: P47989
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_XDH
BioGPS: 7498
PathwayNCI Pathway Interaction Database: XDH
KEGG: XDH
REACTOME: XDH
Pathway Commons: XDH
ContextiHOP: XDH
ligand binding site mutation search in PubMed: XDH
UCL Cancer Institute: XDH
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0001933negative regulation of protein phosphorylation18386220
GO:0001937negative regulation of endothelial cell proliferation18386220
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process18386220
GO:0009115xanthine catabolic process17301077
GO:0010629negative regulation of gene expression18386220
GO:0045602negative regulation of endothelial cell differentiation18386220
GO:0051898negative regulation of protein kinase B signaling18386220
GO:1900745positive regulation of p38MAPK cascade18386220
GO:1900747negative regulation of vascular endothelial growth factor signaling pathway18386220
GO:2000379positive regulation of reactive oxygen species metabolic process18386220
GO:2001213negative regulation of vasculogenesis18386220


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Ligand binding site mutations for XDH
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
A1079A1079TCOAD2
V342K343MBRCA1
V259V259ACOAD1
I403I403TCOAD1
V765L763PCOAD1
S806R805WGBM1
A1080V1082ILUAD1
C43C43FLUAD1
C73,N71A72DLUSC1
Q112S111FSKCM1
A301F299VSKCM1
A1080S1081FSKCM1
G114G114RSKCM1
I878E880KSKCM1
S806T804ASTAD1
E1262P1264SSTAD1
S810T811MSTAD1
T750I751VUCEC1
C116,G114F115LUCEC1
V342,A346S344YUCEC1
D430D430YUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for XDH
Protein structure of wild type (WT) and mutant type (MT) of XDH
Wild type XDH
Mutant type XDH

Free energy of binding of drugs to wild type and mutant tpye of XDH
Gene symbolDrug nameFree energy of binding (kcal/mol) of wild typeFree energy of binding (kcal/mol) of mutant type
XDHAllopurinol-6-5.8
XDHOxypurinol-6.4-6

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C73A72D0.25520402
N71A72D0.25520402
A1080S1081F0.0526316
V342K343M0.005301628
V765L763P-1.749549
S806T804A-1.3657124
V259V259A-1.3125426
I403I403T-1.2121067
C116F115L-0.89939502
G114F115L-0.89939502
E1262P1264S-0.87985902
T750I751V-0.80584504
I878E880K-0.77145198
S806R805W-0.72396209
A346S344Y-0.63047061
V342S344Y-0.63047061
Q112S111F-0.5819428
G114G114R-0.56231853
C43C43F-0.54693718
A1079A1079T-0.51885785
A301F299V-0.25977394
D430D430Y-0.2336064
S810T811M-0.11705893
A1080V1082I-0.10952935
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for XDH from PDB
PDB IDPDB titlePDB structure
2CKJHUMAN MILK XANTHINE OXIDOREDUCTASE

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Differential gene expression and gene-gene network for XDH
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of XDH and the right PPI network was created from samples without mutations in the LBS of XDH. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for XDH
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0268118Xanthinuria, Type I8Biomarker, GeneticVariation
umls:C0022116Ischemia3Biomarker
umls:C0035126Reperfusion Injury2Biomarker, Therapeutic
umls:C0018801Heart Failure2Biomarker
umls:C0004352Autistic Disorder1Biomarker
umls:C0007097Carcinoma1Biomarker
umls:C0018799Heart Diseases1Biomarker
umls:C0740392Infarction, Middle Cerebral Artery1Biomarker
umls:C0024667Mammary Neoplasms, Animal1Biomarker
umls:C0024668Mammary Neoplasms, Experimental1Biomarker
umls:C0027746Nerve Degeneration1Biomarker
umls:C0034065Pulmonary Embolism1Biomarker
umls:C0040034Thrombocytopenia1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for XDH
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00437AllopurinolSmall molecule
ApprovedDB00583L-CarnitineSmall molecule
ExperimentalDB016854-[5-Pyridin-4-Yl-1h-[1,2,4]Triazol-3-Yl]-Pyridine-2-CarbonitrileSmall molecule
ApprovedDB03147Flavin adenine dinucleotideSmall molecule
ExperimentalDB03328dioxothiomolybdenum(VI) ionSmall molecule
InvestigationalDB03516EniluracilSmall molecule
ExperimentalDB03841Y-700Small molecule
ApprovedDB04854FebuxostatSmall molecule
InvestigationalDB05262OxypurinolSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of XDH go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
MOMHYDROXY(DIOXO)MOLYBDENUM2e1qAA1079 A1080 E1262
MOMHYDROXY(DIOXO)MOLYBDENUM2e1qBA1079 A1080 E1262
MOMHYDROXY(DIOXO)MOLYBDENUM2e1qCA1079 A1080 E1262
MOMHYDROXY(DIOXO)MOLYBDENUM2e1qDA1079 A1080 E1262
FESDI-MU-SULFIDO-DIIRON2ckjAC43 C73
FESDI-MU-SULFIDO-DIIRON2ckjBC43 C73
FESDI-MU-SULFIDO-DIIRON2ckjDC43 C73
FESDI-MU-SULFIDO-DIIRON2ckjCC43 N71 C73
FESDI-MU-SULFIDO-DIIRON2e1qAC43 N71 C73
FESDI-MU-SULFIDO-DIIRON2e1qBC43 N71 C73
FESDI-MU-SULFIDO-DIIRON2e1qCC43 N71 C73
FESDI-MU-SULFIDO-DIIRON2e1qDC43 N71 C73
FESDI-MU-SULFIDO-DIIRON2ckjDG114 C116
BCTHYDROGENCARBONATE2e1qAI878
BCTHYDROGENCARBONATE2e1qBI878
BCTHYDROGENCARBONATE2e1qCI878
BCTHYDROGENCARBONATE2e1qDI878
FESDI-MU-SULFIDO-DIIRON2ckjAQ112 G114 C116
FESDI-MU-SULFIDO-DIIRON2ckjBQ112 G114 C116
FESDI-MU-SULFIDO-DIIRON2ckjCQ112 G114 C116
FESDI-MU-SULFIDO-DIIRON2e1qAQ112 G114 C116
FESDI-MU-SULFIDO-DIIRON2e1qBQ112 G114 C116
FESDI-MU-SULFIDO-DIIRON2e1qCQ112 G114 C116
FESDI-MU-SULFIDO-DIIRON2e1qDQ112 G114 C116
CACALCIUM(2+)2e1qDT750 V765 S806 S810
FADFAD2ckjCV259 A301 A346 I403
FADFAD2ckjDV259 A301 A346 I403 D430
FADFAD2e1qBV259 A301 V342 A346 I403
FADFAD2e1qCV259 A301 V342 A346 I403
FADFAD2e1qDV259 A301 V342 A346 I403
FADFAD2ckjBV259 A346
FADFAD2ckjAV259 A346 I403
FADFAD2e1qAV259 V342 A346 I403
CACALCIUM(2+)2e1qAV765 S806 S810
CACALCIUM(2+)2e1qBV765 S806 S810
CACALCIUM(2+)2e1qCV765 S806 S810


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Conservation information for LBS of XDH
Multiple alignments for P47989 in multiple species
LBSAA sequence# speciesSpecies
A1079NTSPTAASVSA2Homo sapiens, Gallus gallus
A1079NASPTAASASS2Arabidopsis thaliana, Arabidopsis thaliana
A1079NTSPTAASASA2Mus musculus, Rattus norvegicus
A1079NATPTAASASS1Oryza sativa subsp. japonica
A1079NTSPTAASVGS1Drosophila melanogaster
A1079NSSPTAASVST1Bos taurus
A1080TSPTAASVSAD2Homo sapiens, Gallus gallus
A1080ASPTAASASSD2Arabidopsis thaliana, Arabidopsis thaliana
A1080TSPTAASASAD2Mus musculus, Rattus norvegicus
A1080ATPTAASASSD1Oryza sativa subsp. japonica
A1080TSPTAASVGSD1Drosophila melanogaster
A1080SSPTAASVSTD1Bos taurus
A301GISFGAACPLS2Homo sapiens, Mus musculus
A301GIEVGSALRLS2Arabidopsis thaliana, Arabidopsis thaliana
A301GIHIGSSVRLA1Oryza sativa subsp. japonica
A301GIYFGAAVSLM1Drosophila melanogaster
A301GITFGAACTLS1Gallus gallus
A301GISFGAACALS1Bos taurus
A301GISFGASCPLS1Rattus norvegicus
A338QLRWFAGKQVK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A338QLKWFAGTQIR3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
A338MLHYFAGKQIR1Drosophila melanogaster
A338QLRWFAGPQIR1Gallus gallus
A346QIRNVACIGGN2Arabidopsis thaliana, Arabidopsis thaliana
A346QVKSVASIGGN2Mus musculus, Rattus norvegicus
A346QVKSVASVGGN1Homo sapiens
A346QIRNVASVGGN1Oryza sativa subsp. japonica
A346QIRNVACLGGN1Drosophila melanogaster
A346QIRNVAALGGN1Gallus gallus
A346QVKSVASLGGN1Bos taurus
C113SHGSQCGFCTP7Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
C113AHGSQCGFCTP2Oryza sativa subsp. japonica, Drosophila melanogaster
C116SQCGFCTPGIV6Homo sapiens, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
C116SQCGFCTPGFV2Oryza sativa subsp. japonica, Arabidopsis thaliana
C116SQCGFCTPGFI1Arabidopsis thaliana
C148FQGNLCRCTGY6Homo sapiens, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
C148LAGNLCRCTGY3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
C150GNLCRCTGYRP9Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
C43GTKLGCGEGGC8Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
C43GTKLGCAEGGC1Drosophila melanogaster
C48CGEGGCGACTV7Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
C48CGEGGCGSCTV1Arabidopsis thaliana
C48CAEGGCGACTV1Drosophila melanogaster
C51GGCGACTVMVS3Oryza sativa subsp. japonica, Arabidopsis thaliana, Drosophila melanogaster
C51GGCGACTVMIS3Gallus gallus, Mus musculus, Rattus norvegicus
C51GGCGACTVMLS2Homo sapiens, Bos taurus
C51GGCGSCTVMVS1Arabidopsis thaliana
C73FSANACLAPIC2Homo sapiens, Bos taurus
C73YAVNACLAPLY2Arabidopsis thaliana, Arabidopsis thaliana
C73FAINACLAPLY1Oryza sativa subsp. japonica
C73LAVNACLTPVC1Drosophila melanogaster
C73HTANACLFPIC1Gallus gallus
C73FSVNACLTPIC1Mus musculus
C73FSVNACLAPIC1Rattus norvegicus
C749YLETHCTIAVP2Homo sapiens, Mus musculus
C749YLEPNGSLVWT2Arabidopsis thaliana, Arabidopsis thaliana
C749YMEPQSTLVWP1Oryza sativa subsp. japonica
C749YLETHAALAVP1Drosophila melanogaster
C749YLETHCTLAVP1Gallus gallus
C749YLETHCTIAIP1Bos taurus
C749YLETNCTIAVP1Rattus norvegicus
D360ASPISDLNPVF3Homo sapiens, Bos taurus, Rattus norvegicus
D360ASPISDLNPLW3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
D360ASPISDLNPVL2Gallus gallus, Mus musculus
D360GSPISDMNPVL1Drosophila melanogaster
D429ASRREDDIAKV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D429AHRRDDDIAIV2Arabidopsis thaliana, Arabidopsis thaliana
D429AHRREDDIALV1Oryza sativa subsp. japonica
D429ARRRDDDIAIV1Drosophila melanogaster
D429AYRREDDIAIV1Gallus gallus
D430SRREDDIAKVT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D430HRRDDDIAIVN2Arabidopsis thaliana, Arabidopsis thaliana
D430HRREDDIALVN1Oryza sativa subsp. japonica
D430RRRDDDIAIVN1Drosophila melanogaster
D430YRREDDIAIVT1Gallus gallus
E1262SKAVGEPPLFL5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E1262SKAVGEPPFFL3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
E1262SKAVGEPPLFI1Drosophila melanogaster
E263VVGNTEIGIEM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E263LVGNTEVGIEM2Arabidopsis thaliana, Arabidopsis thaliana
E263IIGNSEVGVET1Oryza sativa subsp. japonica
E263VVGNTEVGVEV1Drosophila melanogaster
E263VVGNTEVGIEM1Gallus gallus
E45KLGCGEGGCGA7Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E45KLGCGEGGCGS1Arabidopsis thaliana
E45KLGCAEGGCGA1Drosophila melanogaster
E741YIGGQEHFYLE3Homo sapiens, Mus musculus, Rattus norvegicus
E741QMGGQEHFYLE2Arabidopsis thaliana, Arabidopsis thaliana
E741QVGGQEHFYME1Oryza sativa subsp. japonica
E741RMGGQEHFYLE1Drosophila melanogaster
E741HIGGQEHFYLE1Gallus gallus
E741YIGGQDHFYLE1Bos taurus
F337EQLRWFAGKQV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F337EQLKWFAGTQI2Arabidopsis thaliana, Arabidopsis thaliana
F337RQLKWFAGTQI1Oryza sativa subsp. japonica
F337DMLHYFAGKQI1Drosophila melanogaster
F337EQLRWFAGPQI1Gallus gallus
F912PSNTAFRGFGG7Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, Rattus norvegicus
F912SSNTAFRGFGG2Gallus gallus, Bos taurus
F915TAFRGFGGPQG7Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus
F915TAFRGFGGPQA2Oryza sativa subsp. japonica, Bos taurus
G114HGSQCGFCTPG9Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G260AKLVVGNTEIG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G260AKLLVGNTEVG2Arabidopsis thaliana, Arabidopsis thaliana
G260AKLVVGNTEVG2Drosophila melanogaster, Gallus gallus
G260AKLIIGNSEVG1Oryza sativa subsp. japonica
G349NVACIGGNICT2Arabidopsis thaliana, Arabidopsis thaliana
G349SVASIGGNIIT2Mus musculus, Rattus norvegicus
G349SVASVGGNIIT1Homo sapiens
G349NVASVGGNICT1Oryza sativa subsp. japonica
G349NVACLGGNIMT1Drosophila melanogaster
G349NVAALGGNIMT1Gallus gallus
G349SVASLGGNIIT1Bos taurus
G350VACIGGNICTA2Arabidopsis thaliana, Arabidopsis thaliana
G350VASIGGNIITA2Mus musculus, Rattus norvegicus
G350VASVGGNIITA1Homo sapiens
G350VASVGGNICTA1Oryza sativa subsp. japonica
G350VACLGGNIMTG1Drosophila melanogaster
G350VAALGGNIMTA1Gallus gallus
G350VASLGGNIITA1Bos taurus
G42CGTKLGCGEGG3Gallus gallus, Mus musculus, Rattus norvegicus
G42TGTKLGCGEGG2Arabidopsis thaliana, Arabidopsis thaliana
G42SGTKLGCGEGG1Homo sapiens
G42PGTKLGCGEGG1Oryza sativa subsp. japonica
G42CGTKLGCAEGG1Drosophila melanogaster
G42RGTKLGCGEGG1Bos taurus
G44TKLGCGEGGCG8Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G44TKLGCAEGGCG1Drosophila melanogaster
G46LGCGEGGCGAC7Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G46LGCGEGGCGSC1Arabidopsis thaliana
G46LGCAEGGCGAC1Drosophila melanogaster
G47GCGEGGCGACT7Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G47GCGEGGCGSCT1Arabidopsis thaliana
G47GCAEGGCGACT1Drosophila melanogaster
G49GEGGCGACTVM7Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G49GEGGCGSCTVM1Arabidopsis thaliana
G49AEGGCGACTVM1Drosophila melanogaster
G838DMLITGGRHPF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G838DMMITGHRHSF2Arabidopsis thaliana, Arabidopsis thaliana
G838DMMTTGQRHSF1Oryza sativa subsp. japonica
G838DMLITGTRHPF1Drosophila melanogaster
G838DMLISGGRHPF1Gallus gallus
G916AFRGFGGPQGM7Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus
G916AFRGFGGPQAM1Oryza sativa subsp. japonica
G916AFRGFGGPQAL1Bos taurus
H742IGGQEHFYLET4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
H742MGGQEHFYLEP2Arabidopsis thaliana, Arabidopsis thaliana
H742VGGQEHFYMEP1Oryza sativa subsp. japonica
H742MGGQEHFYLET1Drosophila melanogaster
H742IGGQDHFYLET1Bos taurus
H841ITGGRHPFLAR2Homo sapiens, Bos taurus
H841ITGGRHPFLAK2Mus musculus, Rattus norvegicus
H841TTGQRHSFLGK1Oryza sativa subsp. japonica
H841ITGHRHSFVGK1Arabidopsis thaliana
H841ITGHRHSFLGK1Arabidopsis thaliana
H841ITGTRHPFLFK1Drosophila melanogaster
H841ISGGRHPFLGR1Gallus gallus
I264VGNTEIGIEMK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I264VGNTEVGIEMR3Arabidopsis thaliana, Arabidopsis thaliana, Gallus gallus
I264IGNSEVGVETK1Oryza sativa subsp. japonica
I264VGNTEVGVEVK1Drosophila melanogaster
I353IGGNICTASPI2Arabidopsis thaliana, Arabidopsis thaliana
I353IGGNIITASPI2Mus musculus, Rattus norvegicus
I353VGGNIITASPI1Homo sapiens
I353VGGNICTASPI1Oryza sativa subsp. japonica
I353LGGNIMTGSPI1Drosophila melanogaster
I353LGGNIMTASPI1Gallus gallus
I353LGGNIITASPI1Bos taurus
I403MGSNEILLSVF2Arabidopsis thaliana, Arabidopsis thaliana
I403LSPEEILLSIE1Homo sapiens
I403LKPDEILLSVI1Oryza sativa subsp. japonica
I403IEAHEVLLGIH1Drosophila melanogaster
I403VKPEEVLLSVE1Gallus gallus
I403LGPEEILLSIE1Bos taurus
I403LSPEEILVSIV1Mus musculus
I403LRPEEILLSIE1Rattus norvegicus
I431RREDDIAKVTS3Homo sapiens, Mus musculus, Rattus norvegicus
I431RRDDDIAIVNG2Arabidopsis thaliana, Arabidopsis thaliana
I431RREDDIALVNA1Oryza sativa subsp. japonica
I431RRDDDIAIVNA1Drosophila melanogaster
I431RREDDIAIVTC1Gallus gallus
I431RREDDIAKVTC1Bos taurus
I878DLSQSIMERAL1Homo sapiens
I878DLSLPVLERAM1Oryza sativa subsp. japonica
I878DLSLSNLERAM1Arabidopsis thaliana
I878DLSLSVLERAM1Arabidopsis thaliana
I878DLSFSVLERAM1Drosophila melanogaster
I878DLSHGVMDRAL1Gallus gallus
I878DLSHSIMERAL1Bos taurus
I878DLSRSIMERAV1Mus musculus
I878DLSRSIMERAL1Rattus norvegicus
K256QHPDAKLVVGN3Homo sapiens, Mus musculus, Rattus norvegicus
K256CYPNAKLIIGN1Oryza sativa subsp. japonica
K256NFPDAKLLVGN1Arabidopsis thaliana
K256NYPDAKLLVGN1Arabidopsis thaliana
K256KHPAAKLVVGN1Drosophila melanogaster
K256QYPNAKLVVGN1Gallus gallus
K256QHPEAKLVVGN1Bos taurus
K422FFSAFKQASRR3Bos taurus, Mus musculus, Rattus norvegicus
K422YVKEFKQAHRR2Arabidopsis thaliana, Arabidopsis thaliana
K422YFSAFKQASRR1Homo sapiens
K422FVKEFKQAHRR1Oryza sativa subsp. japonica
K422YIVAFKQARRR1Drosophila melanogaster
K422YFSAFKQAYRR1Gallus gallus
L257HPDAKLVVGNT3Homo sapiens, Mus musculus, Rattus norvegicus
L257YPNAKLIIGNS1Oryza sativa subsp. japonica
L257FPDAKLLVGNT1Arabidopsis thaliana
L257YPDAKLLVGNT1Arabidopsis thaliana
L257HPAAKLVVGNT1Drosophila melanogaster
L257YPNAKLVVGNT1Gallus gallus
L257HPEAKLVVGNT1Bos taurus
L404GSNEILLSVFL2Arabidopsis thaliana, Arabidopsis thaliana
L404SPEEILLSIEI1Homo sapiens
L404KPDEILLSVIL1Oryza sativa subsp. japonica
L404EAHEVLLGIHF1Drosophila melanogaster
L404KPEEVLLSVEI1Gallus gallus
L404GPEEILLSIEI1Bos taurus
L404SPEEILVSIVI1Mus musculus
L404RPEEILLSIEI1Rattus norvegicus
L41LCGTKLGCGEG3Gallus gallus, Mus musculus, Rattus norvegicus
L41LTGTKLGCGEG2Arabidopsis thaliana, Arabidopsis thaliana
L41LSGTKLGCGEG1Homo sapiens
L41LPGTKLGCGEG1Oryza sativa subsp. japonica
L41LCGTKLGCAEG1Drosophila melanogaster
L41LRGTKLGCGEG1Bos taurus
L74AVNACLAPLYS2Arabidopsis thaliana, Arabidopsis thaliana
L74SANACLAPICS1Homo sapiens
L74AINACLAPLYS1Oryza sativa subsp. japonica
L74AVNACLTPVCS1Drosophila melanogaster
L74TANACLFPICA1Gallus gallus
L74SANACLAPICT1Bos taurus
L74SVNACLTPICS1Mus musculus
L74SVNACLAPICS1Rattus norvegicus
L745QEHFYLETHCT3Homo sapiens, Gallus gallus, Mus musculus
L745QEHFYLEPNGS2Arabidopsis thaliana, Arabidopsis thaliana
L745QEHFYMEPQST1Oryza sativa subsp. japonica
L745QEHFYLETHAA1Drosophila melanogaster
L745QDHFYLETHCT1Bos taurus
L745QEHFYLETNCT1Rattus norvegicus
N261KLVVGNTEIGI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N261KLLVGNTEVGI2Arabidopsis thaliana, Arabidopsis thaliana
N261KLIIGNSEVGV1Oryza sativa subsp. japonica
N261KLVVGNTEVGV1Drosophila melanogaster
N261KLVVGNTEVGI1Gallus gallus
N351ACIGGNICTAS2Arabidopsis thaliana, Arabidopsis thaliana
N351ASIGGNIITAS2Mus musculus, Rattus norvegicus
N351ASVGGNIITAS1Homo sapiens
N351ASVGGNICTAS1Oryza sativa subsp. japonica
N351ACLGGNIMTGS1Drosophila melanogaster
N351AALGGNIMTAS1Gallus gallus
N351ASLGGNIITAS1Bos taurus
N71VHYAVNACLAP2Arabidopsis thaliana, Arabidopsis thaliana
N71VHFSANACLAP1Homo sapiens
N71QHFAINACLAP1Oryza sativa subsp. japonica
N71RHLAVNACLTP1Drosophila melanogaster
N71LHHTANACLFP1Gallus gallus
N71IHFSANACLAP1Bos taurus
N71VHFSVNACLTP1Mus musculus
N71VHFSVNACLAP1Rattus norvegicus
Q112KSHGSQCGFCT4Homo sapiens, Gallus gallus, Bos taurus, Mus musculus
Q112SSHGSQCGFCT2Arabidopsis thaliana, Arabidopsis thaliana
Q112MAHGSQCGFCT1Oryza sativa subsp. japonica
Q112KAHGSQCGFCT1Drosophila melanogaster
Q112RSHGSQCGFCT1Rattus norvegicus
Q768LFVSTQNTMKT3Homo sapiens, Mus musculus, Rattus norvegicus
Q768MISSTQAPQKH2Oryza sativa subsp. japonica, Arabidopsis thaliana
Q768MISSTQAPQQH1Arabidopsis thaliana
Q768LFCSTQHPSEV1Drosophila melanogaster
Q768LFVSTQNLMKT1Gallus gallus
Q768LFVSTQNAMKT1Bos taurus
Q919GFGGPQGMLIA3Homo sapiens, Mus musculus, Rattus norvegicus
Q919GFGGPQGMLIT2Arabidopsis thaliana, Arabidopsis thaliana
Q919GFGGPQAMLIA1Oryza sativa subsp. japonica
Q919GFGGPQGMYAG1Drosophila melanogaster
Q919GFGGPQGMMIA1Gallus gallus
Q919GFGGPQALFIA1Bos taurus
R149QGNLCRCTGYR6Homo sapiens, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
R149AGNLCRCTGYR3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
R840LITGGRHPFLA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R840MTTGQRHSFLG1Oryza sativa subsp. japonica
R840MITGHRHSFVG1Arabidopsis thaliana
R840MITGHRHSFLG1Arabidopsis thaliana
R840LITGTRHPFLF1Drosophila melanogaster
R840LISGGRHPFLG1Gallus gallus
R913SNTAFRGFGGP9Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
S347IRNVACIGGNI2Arabidopsis thaliana, Arabidopsis thaliana
S347VKSVASIGGNI2Mus musculus, Rattus norvegicus
S347VKSVASVGGNI1Homo sapiens
S347IRNVASVGGNI1Oryza sativa subsp. japonica
S347IRNVACLGGNI1Drosophila melanogaster
S347IRNVAALGGNI1Gallus gallus
S347VKSVASLGGNI1Bos taurus
S359TASPISDLNPV5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
S359TASPISDLNPL3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
S359TGSPISDMNPV1Drosophila melanogaster
S806GKETRSTVVST2Homo sapiens, Rattus norvegicus
S806GKETRSAFIAA2Arabidopsis thaliana, Arabidopsis thaliana
S806GKETRSAIFAA1Oryza sativa subsp. japonica
S806GKESRGISVAL1Drosophila melanogaster
S806GKETRNTILTT1Gallus gallus
S806GKETRSTLVSV1Bos taurus
S806GKETRSTLIST1Mus musculus
S810RSAFIAAAASV2Arabidopsis thaliana, Arabidopsis thaliana
S810RSTVVSTAVAL1Homo sapiens
S810RSAIFAAAASV1Oryza sativa subsp. japonica
S810RGISVALPVAL1Drosophila melanogaster
S810RNTILTTVVAV1Gallus gallus
S810RSTLVSVAVAL1Bos taurus
S810RSTLISTAVAL1Mus musculus
S810RSTVVSTALAL1Rattus norvegicus
T151NLCRCTGYRPI9Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
T262LVVGNTEIGIE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T262LLVGNTEVGIE2Arabidopsis thaliana, Arabidopsis thaliana
T262LIIGNSEVGVE1Oryza sativa subsp. japonica
T262LVVGNTEVGVE1Drosophila melanogaster
T262LVVGNTEVGIE1Gallus gallus
T354GGNIITASPIS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T354GGNICTASPIS3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
T354GGNIMTGSPIS1Drosophila melanogaster
T354GGNIMTASPIS1Gallus gallus
T750LETHCTIAVPK2Homo sapiens, Mus musculus
T750MEPQSTLVWPV1Oryza sativa subsp. japonica
T750LEPNGSLVWTI1Arabidopsis thaliana
T750LEPNGSLVWTV1Arabidopsis thaliana
T750LETHAALAVPR1Drosophila melanogaster
T750LETHCTLAVPK1Gallus gallus
T750LETHCTIAIPK1Bos taurus
T750LETNCTIAVPK1Rattus norvegicus
T767ELFVSTQNTMK3Homo sapiens, Mus musculus, Rattus norvegicus
T767HMISSTQAPQK2Oryza sativa subsp. japonica, Arabidopsis thaliana
T767HMISSTQAPQQ1Arabidopsis thaliana
T767ELFCSTQHPSE1Drosophila melanogaster
T767ELFVSTQNLMK1Gallus gallus
T767ELFVSTQNAMK1Bos taurus
T773QNTMKTQSFVA2Homo sapiens, Rattus norvegicus
T773QAPQKHQKYVA1Oryza sativa subsp. japonica
T773QAPQQHQKYVS1Arabidopsis thaliana
T773QAPQKHQKYVS1Arabidopsis thaliana
T773QHPSEVQKLVA1Drosophila melanogaster
T773QNLMKTQEFTA1Gallus gallus
T773QNAMKTQSFVA1Bos taurus
T773QNTMKTQSFIA1Mus musculus
T807KETRSTVVSTA2Homo sapiens, Rattus norvegicus
T807KETRSAFIAAA2Arabidopsis thaliana, Arabidopsis thaliana
T807KETRSAIFAAA1Oryza sativa subsp. japonica
T807KESRGISVALP1Drosophila melanogaster
T807KETRNTILTTV1Gallus gallus
T807KETRSTLVSVA1Bos taurus
T807KETRSTLISTA1Mus musculus
T837EDMLITGGRHP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T837VDMMITGHRHS2Arabidopsis thaliana, Arabidopsis thaliana
T837IDMMTTGQRHS1Oryza sativa subsp. japonica
T837EDMLITGTRHP1Drosophila melanogaster
T837EDMLISGGRHP1Gallus gallus
T910NLPSNTAFRGF4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
T910NFPSNTAFRGF3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
T910NLSSNTAFRGF2Gallus gallus, Bos taurus
V258PDAKLVVGNTE3Homo sapiens, Mus musculus, Rattus norvegicus
V258PDAKLLVGNTE2Arabidopsis thaliana, Arabidopsis thaliana
V258PNAKLIIGNSE1Oryza sativa subsp. japonica
V258PAAKLVVGNTE1Drosophila melanogaster
V258PNAKLVVGNTE1Gallus gallus
V258PEAKLVVGNTE1Bos taurus
V259DAKLVVGNTEI3Homo sapiens, Mus musculus, Rattus norvegicus
V259DAKLLVGNTEV2Arabidopsis thaliana, Arabidopsis thaliana
V259NAKLIIGNSEV1Oryza sativa subsp. japonica
V259AAKLVVGNTEV1Drosophila melanogaster
V259NAKLVVGNTEV1Gallus gallus
V259EAKLVVGNTEI1Bos taurus
V342FAGKQVKSVAS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V342FAGTQIRNVAC2Arabidopsis thaliana, Arabidopsis thaliana
V342FAGTQIRNVAS1Oryza sativa subsp. japonica
V342FAGKQIRNVAC1Drosophila melanogaster
V342FAGPQIRNVAA1Gallus gallus
V765EMELFVSTQNT3Homo sapiens, Mus musculus, Rattus norvegicus
V765EVHMISSTQAP2Arabidopsis thaliana, Arabidopsis thaliana
V765EIHMISSTQAP1Oryza sativa subsp. japonica
V765ELELFCSTQHP1Drosophila melanogaster
V765EMELFVSTQNL1Gallus gallus
V765EMELFVSTQNA1Bos taurus
V809TRSAFIAAAAS2Arabidopsis thaliana, Arabidopsis thaliana
V809TRSTVVSTAVA1Homo sapiens
V809TRSAIFAAAAS1Oryza sativa subsp. japonica
V809SRGISVALPVA1Drosophila melanogaster
V809TRNTILTTVVA1Gallus gallus
V809TRSTLVSVAVA1Bos taurus
V809TRSTLISTAVA1Mus musculus
V809TRSTVVSTALA1Rattus norvegicus
Y744GQEHFYLETHC3Homo sapiens, Gallus gallus, Mus musculus
Y744GQEHFYLEPNG2Arabidopsis thaliana, Arabidopsis thaliana
Y744GQEHFYMEPQS1Oryza sativa subsp. japonica
Y744GQEHFYLETHA1Drosophila melanogaster
Y744GQDHFYLETHC1Bos taurus
Y744GQEHFYLETNC1Rattus norvegicus


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