mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ZNF24
Gene summary
Basic gene Info.Gene symbolZNF24
Gene namezinc finger protein 24
CytomapUCSC genome browser: 18q12
Type of geneprotein-coding
Descriptionlacks zinc finger domainretinoic acid suppression protein Azinc finger and SCAN domain-containing protein 3zinc finger protein 191zinc finger protein 24 (KOX 17)zinc finger protein KOX17
Modification date20141207
dbXrefs MIM : 194534
Ensembl : ENSG00000172466
HPRD : 01921
Vega : OTTHUMG00000132565
ProteinUniProt: P17028
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ZNF24
BioGPS: 7572
PathwayNCI Pathway Interaction Database: ZNF24
Pathway Commons: ZNF24
ContextiHOP: ZNF24
ligand binding site mutation search in PubMed: ZNF24
UCL Cancer Institute: ZNF24
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0045892negative regulation of transcription, DNA-templated10585455

Ligand binding site mutations for ZNF24
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ZNF24
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZNF24 from PDB

Differential gene expression and gene-gene network for ZNF24
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ZNF24 and the right PPI network was created from samples without mutations in the LBS of ZNF24. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ZNF24
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ZNF24
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ZNF24 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ZNF24
Multiple alignments for P17028 in multiple species
LBSAA sequence# speciesSpecies
C281EKPYGCVECGK3Homo sapiens, Mus musculus, Rattus norvegicus
C284YGCVECGKAFS3Homo sapiens, Mus musculus, Rattus norvegicus
H297SILVQHQRVHT3Homo sapiens, Mus musculus, Rattus norvegicus
H301QHQRVHTGEKP3Homo sapiens, Mus musculus, Rattus norvegicus

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