mutLBSgeneDB |
Gene summary for ZNF24 |
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Basic gene Info. | Gene symbol | ZNF24 |
Gene name | zinc finger protein 24 | |
Synonyms | KOX17|RSG-A|ZNF191|ZSCAN3|Zfp191 | |
Cytomap | UCSC genome browser: 18q12 | |
Type of gene | protein-coding | |
RefGenes | NM_006965.2, | |
Description | lacks zinc finger domainretinoic acid suppression protein Azinc finger and SCAN domain-containing protein 3zinc finger protein 191zinc finger protein 24 (KOX 17)zinc finger protein KOX17 | |
Modification date | 20141207 | |
dbXrefs | MIM : 194534 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172466 | ||
HPRD : 01921 | ||
Vega : OTTHUMG00000132565 | ||
Protein | UniProt: P17028 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZNF24 | |
BioGPS: 7572 | ||
Pathway | NCI Pathway Interaction Database: ZNF24 | |
KEGG: ZNF24 | ||
REACTOME: ZNF24 | ||
Pathway Commons: ZNF24 | ||
Context | iHOP: ZNF24 | |
ligand binding site mutation search in PubMed: ZNF24 | ||
UCL Cancer Institute: ZNF24 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0045892 | negative regulation of transcription, DNA-templated | 10585455 |
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Ligand binding site mutations for ZNF24 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | C281 | C281R | COAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ZNF24 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C281 | C281R | -0.67984125 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for ZNF24 |
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Phenotype information for ZNF24 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ZNF24 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ZNF24 |
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LBS | AA sequence | # species | Species | C281 | EKPYGCVECGK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C284 | YGCVECGKAFS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H297 | SILVQHQRVHT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H301 | QHQRVHTGEKP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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