mutLBSgeneDB |
Gene summary for ZNF32 |
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Basic gene Info. | Gene symbol | ZNF32 |
Gene name | zinc finger protein 32 | |
Synonyms | KOX30 | |
Cytomap | UCSC genome browser: 10q22-q25 | |
Type of gene | protein-coding | |
RefGenes | NM_001005368.1, NM_006973.2, | |
Description | C2H2-546zinc finger protein 32 (KOX 30)zinc finger protein KOX30 | |
Modification date | 20141207 | |
dbXrefs | MIM : 194539 | |
HGNC : HGNC | ||
Ensembl : ENSG00000169740 | ||
HPRD : 01924 | ||
Vega : OTTHUMG00000018043 | ||
Protein | UniProt: P17041 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZNF32 | |
BioGPS: 7580 | ||
Pathway | NCI Pathway Interaction Database: ZNF32 | |
KEGG: ZNF32 | ||
REACTOME: ZNF32 | ||
Pathway Commons: ZNF32 | ||
Context | iHOP: ZNF32 | |
ligand binding site mutation search in PubMed: ZNF32 | ||
UCL Cancer Institute: ZNF32 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ZNF32 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | H207 | H207R | KIRC | 1 | C194 | Q193H | LUAD | 1 | C191 | D192E | STAD | 1 | C107 | E106Q | STAD | 1 | H95 | T93M | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ZNF32 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C107 | E106Q | -1.3482312 | C194 | Q193H | -0.82058554 | H95 | T93M | -0.5493611 | C191 | D192E | -0.39983907 | H207 | H207R | -0.33624919 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for ZNF32 |
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Phenotype information for ZNF32 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ZNF32 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 2epu | A | C107 | ZN | ZINC(2+) | 2ept | A | H95 |
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Conservation information for LBS of ZNF32 |
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LBS | AA sequence | # species | Species |
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