mutLBSgeneDB |
Gene summary for PTP4A1 |
Gene summary |
Basic gene Info. | Gene symbol | PTP4A1 |
Gene name | protein tyrosine phosphatase type IVA, member 1 | |
Synonyms | HH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1 | |
Cytomap | UCSC genome browser: 6q12 | |
Type of gene | protein-coding | |
RefGenes | NM_003463.4, | |
Description | protein tyrosine phosphatase type IVA 1protein tyrosine phosphatase type IVA protein 1protein-tyrosine phosphatase 4a1protein-tyrosine phosphatase of regenerating liver 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601585 | |
HGNC : HGNC | ||
Ensembl : ENSG00000112245 | ||
HPRD : 03349 | ||
Vega : OTTHUMG00000014949 | ||
Protein | UniProt: Q93096 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PTP4A1 | |
BioGPS: 7803 | ||
Pathway | NCI Pathway Interaction Database: PTP4A1 | |
KEGG: PTP4A1 | ||
REACTOME: PTP4A1 | ||
Pathway Commons: PTP4A1 | ||
Context | iHOP: PTP4A1 | |
ligand binding site mutation search in PubMed: PTP4A1 | ||
UCL Cancer Institute: PTP4A1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for PTP4A1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | A106 | A106T | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for PTP4A1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | A106 | A106T | 0.22215881 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for PTP4A1 from PDB |
Top |
Differential gene expression and gene-gene network for PTP4A1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for PTP4A1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0017661 | Glomerulonephritis, IGA | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for PTP4A1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of PTP4A1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SO4 | SULFATE | 1xm2 | B | A106 | SO4 | SULFATE | 1xm2 | D | A106 |
Top |
Conservation information for LBS of PTP4A1 |
Multiple alignments for Q93096 in multiple species |
LBS | AA sequence | # species | Species | A106 | AVHCVAGLGRA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D72 | DWPFDDGAPPS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G107 | VHCVAGLGRAP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G109 | CVAGLGRAPVL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L108 | HCVAGLGRAPV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R110 | VAGLGRAPVLV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V105 | IAVHCVAGLGR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |