mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAPKAPK3
Gene summary
Basic gene Info.Gene symbolMAPKAPK3
Gene namemitogen-activated protein kinase-activated protein kinase 3
CytomapUCSC genome browser: 3p21.3
Type of geneprotein-coding
DescriptionMAP kinase-activated protein kinase 3MAPK-activated protein kinase 3MAPKAP kinase 3chromosome 3p kinase
Modification date20141207
dbXrefs MIM : 602130
Ensembl : ENSG00000114738
HPRD : 03678
Vega : OTTHUMG00000156850
ProteinUniProt: Q16644
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAPKAPK3
BioGPS: 7867
PathwayNCI Pathway Interaction Database: MAPKAPK3
Pathway Commons: MAPKAPK3
ligand binding site mutation search in PubMed: MAPKAPK3
UCL Cancer Institute: MAPKAPK3
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0018105peptidyl-serine phosphorylation15850461
GO:0034097response to cytokine8774846

Ligand binding site mutations for MAPKAPK3

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MAPKAPK3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAPKAPK3 from PDB

Differential gene expression and gene-gene network for MAPKAPK3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAPKAPK3 and the right PPI network was created from samples without mutations in the LBS of MAPKAPK3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MAPKAPK3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MAPKAPK3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB077282-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONESmall molecule
ExperimentalDB083582-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAPKAPK3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of MAPKAPK3
Multiple alignments for Q16644 in multiple species
LBSAA sequence# speciesSpecies
A71TGQKCALKLLY2Homo sapiens, Bos taurus
A71SGQKCALKLLY2Mus musculus, Rattus norvegicus
A71TQQNYALKVLL1Drosophila melanogaster
C120LIIMECMEGGE2Homo sapiens, Bos taurus
C120LIVMECMEGGE2Mus musculus, Rattus norvegicus
C120LVVMECMEGGE1Drosophila melanogaster
D187VLKLTDFGFAK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D187TLKLTDFGFAK1Drosophila melanogaster
E119LLIIMECMEGG2Homo sapiens, Bos taurus
E119LLIVMECMEGG2Mus musculus, Rattus norvegicus
E119LLVVMECMEGG1Drosophila melanogaster
E122VMECMEGGELF3Drosophila melanogaster, Mus musculus, Rattus norvegicus
E122IMECMEGGELF2Homo sapiens, Bos taurus
E170RDVKPENLLYT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E170RDLKPENLLYT1Drosophila melanogaster
G123MECMEGGELFS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G123MECMEGGELFQ1Drosophila melanogaster
G124ECMEGGELFSR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G124ECMEGGELFQR1Drosophila melanogaster
G51SKQVLGLGVNG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G51SNTVLGYGING1Drosophila melanogaster
G53QVLGLGVNGKV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G53TVLGYGINGKV1Drosophila melanogaster
K177LLYTSKEKDAV3Homo sapiens, Mus musculus, Rattus norvegicus
K177LLYTTTQPNAT1Drosophila melanogaster
K177LLYTSKDKDAV1Bos taurus
K73QKCALKLLYDS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K73QNYALKVLLDS1Drosophila melanogaster
L173KPENLLYTSKE3Homo sapiens, Mus musculus, Rattus norvegicus
L173KPENLLYTTTQ1Drosophila melanogaster
L173KPENLLYTSKD1Bos taurus
L50LSKQVLGLGVN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L50TSNTVLGYGIN1Drosophila melanogaster
L52KQVLGLGVNGK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L52NTVLGYGINGK1Drosophila melanogaster
M118CLLIIMECMEG2Homo sapiens, Bos taurus
M118CLLIVMECMEG2Mus musculus, Rattus norvegicus
M118CLLVVMECMEG1Drosophila melanogaster
M121IIMECMEGGEL2Homo sapiens, Bos taurus
M121IVMECMEGGEL2Mus musculus, Rattus norvegicus
M121VVMECMEGGEL1Drosophila melanogaster
N171DVKPENLLYTS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N171DLKPENLLYTT1Drosophila melanogaster
T186AVLKLTDFGFA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T186ATLKLTDFGFA1Drosophila melanogaster
V58GVNGKVLECFH2Homo sapiens, Bos taurus
V58GVNGKVLECYH2Mus musculus, Rattus norvegicus
V58GINGKVVQCTH1Drosophila melanogaster

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