mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for USP7
Gene summary
Basic gene Info.Gene symbolUSP7
Gene nameubiquitin specific peptidase 7 (herpes virus-associated)
SynonymsHAUSP|TEF1
CytomapUCSC genome browser: 16p13.3
Type of geneprotein-coding
RefGenesNM_001286457.1,
NM_001286458.1,NM_003470.2,
DescriptionHerpes virus-associated ubiquitin-specific proteasedeubiquitinating enzyme 7herpesvirus-associated ubiquitin-specific proteaseubiquitin carboxyl-terminal hydrolase 7ubiquitin specific protease 7 (herpes virus-associated)ubiquitin thioesterase 7ubiqu
Modification date20141222
dbXrefs MIM : 602519
HGNC : HGNC
Ensembl : ENSG00000187555
HPRD : 03950
Vega : OTTHUMG00000176903
ProteinUniProt: Q93009
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_USP7
BioGPS: 7874
PathwayNCI Pathway Interaction Database: USP7
KEGG: USP7
REACTOME: USP7
Pathway Commons: USP7
ContextiHOP: USP7
ligand binding site mutation search in PubMed: USP7
UCL Cancer Institute: USP7
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0016579protein deubiquitination16964248
GO:0032088negative regulation of NF-kappaB transcription factor activity11279055
GO:0051090regulation of sequence-specific DNA binding transcription factor activity16964248


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Ligand binding site mutations for USP7

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R104,M100M102LCOAD1
R153R153POV1
S710S710FSKCM1
H683H683YSKCM1
F118F117LSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for USP7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F118F117L0.006910339
S710S710F-1.249959
H683H683Y-0.83738891
R153R153P-0.69523323
M100M102L-0.29203839
R104M102L-0.29203839
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for USP7 from PDB

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Differential gene expression and gene-gene network for USP7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of USP7 and the right PPI network was created from samples without mutations in the LBS of USP7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for USP7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for USP7
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of USP7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (GLY,PRO,ARG,LYS,CYS,ALA,ARG,LYS,THR,ARG)4wpiBH683
IIIPeptide ligand (GLY,PRO,ARG,LYS,CYS,ALA,ARG,LYS,THR,ARG,HIS,ALA,GLU)5c56AH683
IIIPeptide ligand (PRO,ARG,LYS,CYS,ALA,ARG,LYS,THR,ARG)4wphAH683 S710
IIIPeptide ligand (GLY,PRO,ARG,LYS,CYS,ALA,ARG,LYS,THR,ARG)4wpiAH683 S710
IIIPeptide ligand (ALA,HIS,SER,SER)3mqrAM100 F118
IIIPeptide ligand (ALA,SER,THR,SER)4jjqAM100 F118
IIIPeptide ligand (ASP,PRO,GLY,GLU,GLY,PRO,SER,THR)1yy6AM100 R104 F118
IIIPeptide ligand (GLY,ALA,ARG,ALA,HIS,SER,SER)2fojAM100 R104 F118
IIIPeptide ligand (GLU,PRO,GLY,GLY,SER,ARG)2fooAM100 R104 F118
IIIPeptide ligand (GLU,LYS,PRO,SER,SER,SER)2fopAM100 R104 F118
IIIPeptide ligand (SER,GLN,PRO,SER,THR,SER,SER)3mqsCM100 R104 F118
IIIPeptide ligand (VAL,SER,PRO,SER,THR,SER,TYR)4kg9AM100 R104 F118
IIIPeptide ligand (SER,VAL,TRP,ILE,PRO,VAL,ASN,GLU,GLY,ALA,SER,THR,SER,GLY,MET)2xxnAM100 R104 F118 R153


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Conservation information for LBS of USP7
Multiple alignments for Q93009 in multiple species
LBSAA sequence# speciesSpecies
A627----QARSNGT4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
A627LERTTQKLTSR1Caenorhabditis elegans
A627------CTAQT1Drosophila melanogaster
A627----DYRRNST1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A627----AKRQNHT1Arabidopsis thaliana
A627----TNRQNRT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A627----VKRHNCT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D164FHKENDWGFSN3Homo sapiens, Gallus gallus, Rattus norvegicus
D164HNTEVDWGFSN1Caenorhabditis elegans
D164YSKENDYGYSN1Drosophila melanogaster
D164FHEENDWGFSN1Mus musculus
D164NALDTDWGFAN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D164NARESDWGFTS1Arabidopsis thaliana
D164RSEVKDWGFTR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D164SPEIVDWGFTQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D682PKFDKDHDVML4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
D682CEYDTARDLLF1Caenorhabditis elegans
D682PPFNPKTESLL1Drosophila melanogaster
D682VFATDNKSNLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D682PEKSKE-DILL1Arabidopsis thaliana
D682ATDDNDFDTYI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D682HQNTGEWNAFI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D684FDKDHDVMLFL4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
D684YDTARDLLFFV1Caenorhabditis elegans
D684FNPKTESLLFL1Drosophila melanogaster
D684ATDNKSNLLFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D684KSKE-DILLFF1Arabidopsis thaliana
D684DDNDFDTYIFL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D684NTGEWNAFIFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D754YDVSLDKAL--4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
D754VDLTQNYSIGR1Caenorhabditis elegans
D754LNEPIESALFI1Drosophila melanogaster
D754IYMKETIYD--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D754LDKKTSFRL--1Arabidopsis thaliana
D754LDPNASFEK--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D754LRLEKTFTQ--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D758AL---DELMDG4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
D758SIGRLVEEQDG1Caenorhabditis elegans
D758ALFIPQDHLQG1Drosophila melanogaster
D758YD---ADIDTG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D758RL---CQIEDG1Arabidopsis thaliana
D758EK---SEIQVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D758TQ---SELSTG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D762-DELMDGDIIV4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
D762LVEEQDGGILV1Caenorhabditis elegans
D762PQDHLQGHILI1Drosophila melanogaster
D762-ADIDTGDIVS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D762-CQIEDGDIIC1Arabidopsis thaliana
D762-SEIQVGDIIC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D762-SELSTGDIIC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D764ELMDGDIIVFQ4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
D764EEQDGGILVVE1Caenorhabditis elegans
D764DHLQGHILIFE1Drosophila melanogaster
D764DIDTGDIVSFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D764QIEDGDIICFQ1Arabidopsis thaliana
D764EIQVGDIICFE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D764ELSTGDIICFE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E162LFFHKENDWGF3Homo sapiens, Gallus gallus, Rattus norvegicus
E162SFHNTEVDWGF1Caenorhabditis elegans
E162LFYSKENDYGY1Drosophila melanogaster
E162LFFHEENDWGF1Mus musculus
E162RFNALDTDWGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E162QFNARESDWGF1Arabidopsis thaliana
E162RFRSEVKDWGF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E162RFSPEIVDWGF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E736SLILYEEVKPN3Homo sapiens, Rattus norvegicus, Mus musculus
E736ELKYYMEHAAS1Caenorhabditis elegans
E736ELTIYDEYADK1Drosophila melanogaster
E736NLILYEEVKPN1Gallus gallus
E736KLTFYEEVQPG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E736EIELFEEIKFE1Arabidopsis thaliana
E736PITYYEEIKTG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E736PLNIYEEIKPG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E744KPNLTERIQDY4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
E744AAS---YLELV1Caenorhabditis elegans
E744ADK---KLVNL1Drosophila melanogaster
E744QPG---TINEI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E744KFEPCVMCEHL1Arabidopsis thaliana
E744KTG---MVDVL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E744KPG---MVDFL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E759L---DELMDGD4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
E759IGRLVEEQDGG1Caenorhabditis elegans
E759LFIPQDHLQGH1Drosophila melanogaster
E759D---ADIDTGD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E759L---CQIEDGD1Arabidopsis thaliana
E759K---SEIQVGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E759Q---SELSTGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E83----SESVLSP4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
E83MSRSDNRIMSK1Caenorhabditis elegans
E83----KSQRLSP1Drosophila melanogaster
E83----TNPKYNS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E83----NTRKHYS1Arabidopsis thaliana
E83-----EDKTYS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E83-----DRRAVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F118-SVGFFLQCNA4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
F118FNFGFFLQCNN1Caenorhabditis elegans
F118-ALGFFLQCNG1Drosophila melanogaster
F118-GVAVYLEPHP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F118-HLSMYLDVSD1Arabidopsis thaliana
F118-YASVFLEYLP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F118GFTSIFLEYIP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F167ENDWGFSNFMA4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
F167EVDWGFSNYDQ1Caenorhabditis elegans
F167ENDYGYSNFIT1Drosophila melanogaster
F167DTDWGFANLID1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F167ESDWGFTSFMP1Arabidopsis thaliana
F167VKDWGFTRFVD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F167IVDWGFTQFAE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F679ATLPKFDKDHD4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
F679RPLCEYDTARD1Caenorhabditis elegans
F679GPLPPFNPKTE1Drosophila melanogaster
F679IEPVFATDNKS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F679IPPPEKSKE-D1Arabidopsis thaliana
F679DFGATDDNDFD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F679SLTHQNTGEWN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G166KENDWGFSNFM3Homo sapiens, Gallus gallus, Rattus norvegicus
G166TEVDWGFSNYD1Caenorhabditis elegans
G166KENDYGYSNFI1Drosophila melanogaster
G166EENDWGFSNFM1Mus musculus
G166LDTDWGFANLI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G166RESDWGFTSFM1Arabidopsis thaliana
G166EVKDWGFTRFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G166EIVDWGFTQFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G631QARSNGTKRPA4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
G631TQKLTSRLRPS1Caenorhabditis elegans
G631--CTAQTQKFS1Drosophila melanogaster
G631DYRRNSTLRLT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G631AKRQNHTYRPN1Arabidopsis thaliana
G631TNRQNRTVRVD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G631VKRHNCTVRVE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H683KFDKDHDVMLF4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
H683EYDTARDLLFF1Caenorhabditis elegans
H683PFNPKTESLLF1Drosophila melanogaster
H683FATDNKSNLLF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H683EKSKE-DILLF1Arabidopsis thaliana
H683TDDNDFDTYIF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H683QNTGEWNAFIF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I154FSR-RISHLFF4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
I154IQK-KIHHSFH1Caenorhabditis elegans
I154FTRARIKHLFY1Drosophila melanogaster
I154LIN-KSHHRFN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I154VRK-ETQHQFN1Arabidopsis thaliana
I154QIN-TSHHRFR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I154VAN-SAHCRFS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I709HIYTPISCKIR4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
I709HTMFDCHKRFN1Caenorhabditis elegans
I709CTQQPHTRRLI1Drosophila melanogaster
I709HFAVNQLQQLS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I709RLMVKSSSKPM1Arabidopsis thaliana
I709DLHVSKNSPIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I709TLHVNKSDEIR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K681LPKFDKDHDVM4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
K681LCEYDTARDLL1Caenorhabditis elegans
K681LPPFNPKTESL1Drosophila melanogaster
K681PVFATDNKSNL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K681PPEKSKE-DIL1Arabidopsis thaliana
K681GATDDNDFDTY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K681THQNTGEWNAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K739LYEEVKPNLTE4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
K739YYMEHAAS---1Caenorhabditis elegans
K739IYDEYADK---1Drosophila melanogaster
K739FYEEVQPG---1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K739LFEEIKFEPCV1Arabidopsis thaliana
K739YYEEIKTG---1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K739IYEEIKPG---1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L742EVKPNLTERIQ4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
L742EHAAS---YLE1Caenorhabditis elegans
L742EYADK---KLV1Drosophila melanogaster
L742EVQPG---TIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L742EIKFEPCVMCE1Arabidopsis thaliana
L742EIKTG---MVD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L742EIKPG---MVD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L760---DELMDGDI4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
L760GRLVEEQDGGI1Caenorhabditis elegans
L760FIPQDHLQGHI1Drosophila melanogaster
L760---ADIDTGDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L760---CQIEDGDI1Arabidopsis thaliana
L760---SEIQVGDI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L760---SELSTGDI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M100LPWKIMVMPRF3Homo sapiens, Rattus norvegicus, Mus musculus
M100IPWRILAICRN1Caenorhabditis elegans
M100LPWRIM----V1Drosophila melanogaster
M100LPWKIMVMPRL1Gallus gallus
M100FEWDIL----L1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M100YKWRIL----I1Arabidopsis thaliana
M100TTWRIV----L1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M100RQFKIT----Y1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M637TKRPAMLDNEA4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
M637RLRPSEFIDCK1Caenorhabditis elegans
M637TQKFSHFDFVA1Drosophila melanogaster
M637TLRLTQPINFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M637TYRPNRPLTPQ1Arabidopsis thaliana
M637TVRVDLPLDKK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M637TVRVESPVNEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M761--DELMDGDII4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
M761RLVEEQDGGIL1Caenorhabditis elegans
M761IPQDHLQGHIL1Drosophila melanogaster
M761--ADIDTGDIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M761--CQIEDGDII1Arabidopsis thaliana
M761--SEIQVGDII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M761--SELSTGDII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N169DWGFSNFMAWS4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
N169DWGFSNYDQYD1Caenorhabditis elegans
N169DYGYSNFITWQ1Drosophila melanogaster
N169DWGFANLIDLN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N169DWGFTSFMPLS1Arabidopsis thaliana
N169DWGFTRFVDLR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N169DWGFTQFAELK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N630-QARSNGTKRP4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
N630TTQKLTSRLRP1Caenorhabditis elegans
N630---CTAQTQKF1Drosophila melanogaster
N630-DYRRNSTLRL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N630-AKRQNHTYRP1Arabidopsis thaliana
N630-TNRQNRTVRV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N630-VKRHNCTVRV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q626-----QARSNG4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
Q626SLERTTQKLTS1Caenorhabditis elegans
Q626-------CTAQ1Drosophila melanogaster
Q626-----DYRRNS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q626-----AKRQNH1Arabidopsis thaliana
Q626-----TNRQNR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q626-----VKRHNC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R104IMVMPRFYPDR3Homo sapiens, Rattus norvegicus, Mus musculus
R104ILAICRN-QQG1Caenorhabditis elegans
R104IM----VIPND1Drosophila melanogaster
R104IMVMPRLYPDR1Gallus gallus
R104IL----LFPQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R104IL----IFPKG1Arabidopsis thaliana
R104IV----LFPKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R104IT----YFPQG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R152EKSFSR-RISH2Homo sapiens, Gallus gallus
R152DKSFSR-RISH2Rattus norvegicus, Mus musculus
R152GPSIQK-KIHH1Caenorhabditis elegans
R152AQPFTRARIKH1Drosophila melanogaster
R152TINLIN-KSHH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R152RYTVRK-ETQH1Arabidopsis thaliana
R152TVMQIN-TSHH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R152SLSVAN-SAHC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R153SFSR-RISHLF4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
R153SIQK-KIHHSF1Caenorhabditis elegans
R153PFTRARIKHLF1Drosophila melanogaster
R153NLIN-KSHHRF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R153TVRK-ETQHQF1Arabidopsis thaliana
R153MQIN-TSHHRF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R153SVAN-SAHCRF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R628---QARSNGTK4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
R628ERTTQKLTSRL1Caenorhabditis elegans
R628-----CTAQTQ1Drosophila melanogaster
R628---DYRRNSTL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R628---AKRQNHTY1Arabidopsis thaliana
R628---TNRQNRTV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R628---VKRHNCTV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S155SR-RISHLFFH4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
S155QK-KIHHSFHN1Caenorhabditis elegans
S155TRARIKHLFYS1Drosophila melanogaster
S155IN-KSHHRFNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S155RK-ETQHQFNA1Arabidopsis thaliana
S155IN-TSHHRFRS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S155AN-SAHCRFSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S168NDWGFSNFMAW4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
S168VDWGFSNYDQY1Caenorhabditis elegans
S168NDYGYSNFITW1Drosophila melanogaster
S168TDWGFANLIDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S168SDWGFTSFMPL1Arabidopsis thaliana
S168KDWGFTRFVDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S168VDWGFTQFAEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S629--QARSNGTKR4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
S629RTTQKLTSRLR1Caenorhabditis elegans
S629----CTAQTQK1Drosophila melanogaster
S629--DYRRNSTLR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S629--AKRQNHTYR1Arabidopsis thaliana
S629--TNRQNRTVR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S629--VKRHNCTVR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S710IYTPISCKIRD4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
S710TMFDCHKRFNL1Caenorhabditis elegans
S710TQQPHTRRLID1Drosophila melanogaster
S710FAVNQLQQLSD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S710LMVKSSSKPMD1Arabidopsis thaliana
S710LHVSKNSPISS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S710LHVNKSDEIRS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S84---SESVLSPP4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
S84SRSDNRIMSKP1Caenorhabditis elegans
S84---KSQRLSPP1Drosophila melanogaster
S84---TNPKYNSP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S84---NTRKHYSD1Arabidopsis thaliana
S84----EDKTYSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S84----DRRAVSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V685DKDHDVMLFLK4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
V685DTARDLLFFVK1Caenorhabditis elegans
V685NPKTESLLFLK1Drosophila melanogaster
V685TDNKSNLLFVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V685SKE-DILLFFK1Arabidopsis thaliana
V685DNDFDTYIFLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V685TGEWNAFIFVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W165HKENDWGFSNF3Homo sapiens, Gallus gallus, Rattus norvegicus
W165NTEVDWGFSNY1Caenorhabditis elegans
W165SKENDYGYSNF1Drosophila melanogaster
W165HEENDWGFSNF1Mus musculus
W165ALDTDWGFANL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W165ARESDWGFTSF1Arabidopsis thaliana
W165SEVKDWGFTRF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W165PEIVDWGFTQF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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