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mutLBSgeneDB |
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| Gene summary for DHX58 |
 Gene summary |
| Basic gene Info. | Gene symbol | DHX58 |
| Gene name | DEXH (Asp-Glu-X-His) box polypeptide 58 | |
| Synonyms | D11LGP2|D11lgp2e|LGP2|RLR-3 | |
| Cytomap | UCSC genome browser: 17q21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_024119.2, | |
| Description | RIG-I-like receptor 3RIG-I-like receptor LGP2RLRRNA helicase LGP2ortholog of mouse D11lgp2probable ATP-dependent RNA helicase DHX58probable ATP-dependent helicase LGP2protein D11Lgp2 homolog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608588 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000108771 | ||
| HPRD : 13115 | ||
| Vega : OTTHUMG00000133493 | ||
| Protein | UniProt: Q96C10 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DHX58 | |
| BioGPS: 79132 | ||
| Pathway | NCI Pathway Interaction Database: DHX58 | |
| KEGG: DHX58 | ||
| REACTOME: DHX58 | ||
| Pathway Commons: DHX58 | ||
| Context | iHOP: DHX58 | |
| ligand binding site mutation search in PubMed: DHX58 | ||
| UCL Cancer Institute: DHX58 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0032480 | negative regulation of type I interferon production | 21525357 | GO:0039536 | negative regulation of RIG-I signaling pathway | 18411269 | GO:0045088 | regulation of innate immune response | 18411269 | GO:0045824 | negative regulation of innate immune response | 21525357 |
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| Ligand binding site mutations for DHX58 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C556 | L554P | COAD | 1 | C612 | R613W | LUAD | 1 | R654 | R654H | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DHX58 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C556 | L554P | -1.6875524 | C612 | R613W | -1.0523802 | R654 | R654H | -0.99135042 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DHX58 from PDB |
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| Differential gene expression and gene-gene network for DHX58 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DHX58 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DHX58 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DHX58 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 2rqa | A | C556 C612 | ZN | ZINC(2+) | 3eqt | A | C556 C612 | ZN | ZINC(2+) | 3eqt | B | C556 C612 | NUC | Nucleic Acids | 3eqt | A | R654 |
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| Conservation information for LBS of DHX58 |
| Multiple alignments for Q96C10 in multiple species |
| LBS | AA sequence | # species | Species |
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