mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DHX58
Gene summary
Basic gene Info.Gene symbolDHX58
Gene nameDEXH (Asp-Glu-X-His) box polypeptide 58
CytomapUCSC genome browser: 17q21.2
Type of geneprotein-coding
DescriptionRIG-I-like receptor 3RIG-I-like receptor LGP2RLRRNA helicase LGP2ortholog of mouse D11lgp2probable ATP-dependent RNA helicase DHX58probable ATP-dependent helicase LGP2protein D11Lgp2 homolog
Modification date20141207
dbXrefs MIM : 608588
Ensembl : ENSG00000108771
HPRD : 13115
Vega : OTTHUMG00000133493
ProteinUniProt: Q96C10
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DHX58
BioGPS: 79132
PathwayNCI Pathway Interaction Database: DHX58
Pathway Commons: DHX58
ContextiHOP: DHX58
ligand binding site mutation search in PubMed: DHX58
UCL Cancer Institute: DHX58
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0032480negative regulation of type I interferon production21525357
GO:0039536negative regulation of RIG-I signaling pathway18411269
GO:0045088regulation of innate immune response18411269
GO:0045824negative regulation of innate immune response21525357

Ligand binding site mutations for DHX58
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for DHX58
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DHX58 from PDB

Differential gene expression and gene-gene network for DHX58
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DHX58 and the right PPI network was created from samples without mutations in the LBS of DHX58. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for DHX58
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for DHX58
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DHX58 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)2rqaAC556 C612
ZNZINC(2+)3eqtAC556 C612
ZNZINC(2+)3eqtBC556 C612
NUCNucleic Acids3eqtAR654

Conservation information for LBS of DHX58
Multiple alignments for Q96C10 in multiple species
LBSAA sequence# speciesSpecies

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