mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for DHRS11

Gene summary

Basic gene Info.	Gene symbol	DHRS11
	Gene name	dehydrogenase/reductase (SDR family) member 11
	Synonyms	ARPG836\|SDR24C1
	Cytomap	UCSC genome browser: 17q12
	Type of gene	protein-coding
	RefGenes	NM_024308.3,
	Description	dehydrogenase/reductase SDR family member 11short chain dehydrogenase/reductase family 24C, member 1short-chain dehydrogenase/reductase
	Modification date	20141207
dbXrefs	HGNC : HGNC
	Ensembl : ENSG00000278535
	HPRD : 08331
	Vega : OTTHUMG00000188442
Protein	UniProt: Q6UWP2 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_DHRS11
	BioGPS: 79154
Pathway	NCI Pathway Interaction Database: DHRS11
	KEGG: DHRS11
	REACTOME: DHRS11
	Pathway Commons: DHRS11
Context	iHOP: DHRS11
	ligand binding site mutation search in PubMed: DHRS11
	UCL Cancer Institute: DHRS11
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for DHRS11

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
L71	S72L	LUAD	1
K170	A172V	LUAD	1
V201	V201A	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for DHRS11

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
K170	A172V	-0.7541964
L71	S72L	-0.51114987
V201	V201A	-0.36912113

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DHRS11 from PDB

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Differential gene expression and gene-gene network for DHRS11

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of DHRS11 and the right PPI network was created from samples without mutations in the LBS of DHRS11. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for DHRS11

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for DHRS11

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Experimental	DB03461	2'-Monophosphoadenosine 5'-Diphosphoribose	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DHRS11 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
NAP		NADP ZWITTERION	1xg5	A	L71 K170 V201
NAP		NADP ZWITTERION	1xg5	B	L71 K170 V201
NAP		NADP ZWITTERION	1xg5	C	L71 K170 V201
NAP		NADP ZWITTERION	1xg5	D	L71 K170 V201

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Conservation information for LBS of DHRS11

Multiple alignments for Q6UWP2 in multiple species

LBS	AA sequence	# species	Species
A42	KVVGCARTVGN	3	Homo sapiens, Mus musculus, Bos taurus
A42	KVVGCARSVDK	1	Gallus gallus
A42	KLILAARRLEK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A42	KLILAARRFST	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A98	ICINNAGLA-R	2	Homo sapiens, Bos taurus
A98	VCINNAGLA-R	1	Gallus gallus
A98	ICINNAGMA-R	1	Mus musculus
A98	ILVNNAGKALG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A98	VLINNAGLALG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C69	IPY-RCDLSNE	3	Homo sapiens, Mus musculus, Bos taurus
C69	IPY-KCDLSNE	1	Gallus gallus
C69	VHVAQLDITQA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C69	LPL-KLDVSDL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D70	PY-RCDLSNEE	3	Homo sapiens, Mus musculus, Bos taurus
D70	PY-KCDLSNEE	1	Gallus gallus
D70	HVAQLDITQAE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D70	PL-KLDVSDLK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F205	VVETQFAFKLH	2	Homo sapiens, Bos taurus
F205	LVETGFAFKLH	1	Gallus gallus
F205	LVETQFAFKLH	1	Mus musculus
F205	LVETEFSLVRY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F205	LVETEFSVVRF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G18	LALVTGASGGI	3	Homo sapiens, Mus musculus, Bos taurus
G18	VALVTGASVGI	1	Gallus gallus
G18	TVLITGASAGI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G18	TILITGASSGI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G199	TCISPGVVETQ	2	Homo sapiens, Bos taurus
G199	TCISPGLVETG	1	Gallus gallus
G199	TCISPGLVETQ	1	Mus musculus
G199	ILIAPGLVETE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G199	MEVDPGLVETE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G21	VTGASGGIGAA	3	Homo sapiens, Mus musculus, Bos taurus
G21	VTGASVGIGAA	1	Gallus gallus
G21	ITGASAGIGKA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G21	ITGASSGIGKS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G22	TGASGGIGAAV	3	Homo sapiens, Mus musculus, Bos taurus
G22	TGASVGIGAAV	1	Gallus gallus
G22	TGASAGIGKAT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G22	TGASSGIGKST	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G99	CINNAGLA-RP	3	Homo sapiens, Gallus gallus, Bos taurus
G99	CINNAGMA-RP	1	Mus musculus
G99	LVNNAGKALGS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G99	LINNAGLALGT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I149	GHIININSMCG	2	Mus musculus, Bos taurus
I149	GHIININSMSG	1	Homo sapiens
I149	GHIININSMNG	1	Gallus gallus
I149	GDIVNLGSIAG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I149	GDILNVGSIAG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I23	GASGGIGAAVA	3	Homo sapiens, Mus musculus, Bos taurus
I23	GASVGIGAAVA	1	Gallus gallus
I23	GASAGIGKATA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I23	GASSGIGKSTA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K170	FYSATKYAVTA	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
K170	-YCASKFAVGA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K170	-YCSTKSALAQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K208	TQFAFKLHDKD	3	Homo sapiens, Mus musculus, Bos taurus
K208	TGFAFKLHDND	1	Gallus gallus
K208	TEFSLVRYRGN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K208	TEFSVVRFHGD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L71	Y-RCDLSNEED	3	Homo sapiens, Mus musculus, Bos taurus
L71	Y-KCDLSNEEE	1	Gallus gallus
L71	VAQLDITQAEK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L71	L-KLDVSDLKS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N150	HIININSMCGH	2	Mus musculus, Bos taurus
N150	HIININSMSGH	1	Homo sapiens
N150	HIININSMNGH	1	Gallus gallus
N150	DIVNLGSIAGR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N150	DILNVGSIAGR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N97	DICINNAGLA-	2	Homo sapiens, Bos taurus
N97	DVCINNAGLA-	1	Gallus gallus
N97	DICINNAGMA-	1	Mus musculus
N97	DILVNNAGKAL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N97	DVLINNAGLAL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P198	ATCISPGVVET	2	Homo sapiens, Bos taurus
P198	ATCISPGLVET	2	Gallus gallus, Mus musculus
P198	VILIAPGLVET	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P198	IMEVDPGLVET	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q204	GVVETQFAFKL	2	Homo sapiens, Bos taurus
Q204	GLVETGFAFKL	1	Gallus gallus
Q204	GLVETQFAFKL	1	Mus musculus
Q204	GLVETEFSLVR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q204	GLVETEFSVVR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R43	VVGCARTVGNI	3	Homo sapiens, Mus musculus, Bos taurus
R43	VVGCARSVDKI	1	Gallus gallus
R43	LILAARRLEKL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R43	LILAARRFSTV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S151	IININSMCGHR	2	Mus musculus, Bos taurus
S151	IININSMSGHR	1	Homo sapiens
S151	IININSMNGHS	1	Gallus gallus
S151	IVNLGSIAGRD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S151	ILNVGSIAGRE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S20	LVTGASGGIGA	3	Homo sapiens, Mus musculus, Bos taurus
S20	LVTGASVGIGA	1	Gallus gallus
S20	LITGASAGIGK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S20	LITGASSGIGK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T203	PGVVETQFAFK	2	Homo sapiens, Bos taurus
T203	PGLVETGFAFK	1	Gallus gallus
T203	PGLVETQFAFK	1	Mus musculus
T203	PGLVETEFSLV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T203	PGLVETEFSVV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T44	VGCARTVGNIE	3	Homo sapiens, Mus musculus, Bos taurus
T44	VGCARSVDKIE	1	Gallus gallus
T44	ILAARRLEKLE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T44	ILAARRFSTVE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V120	KDMFNVNVLAL	2	Homo sapiens, Mus musculus
V120	RTMIDVNVMAV	1	Gallus gallus
V120	KEMFNVNVLAL	1	Bos taurus
V120	QDVFDTNVTAL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V120	VTMITTNVLGM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V200	CISPGVVETQF	2	Homo sapiens, Bos taurus
V200	CISPGLVETGF	1	Gallus gallus
V200	CISPGLVETQF	1	Mus musculus
V200	LIAPGLVETEF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V200	EVDPGLVETEF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V201	ISPGVVETQFA	2	Homo sapiens, Bos taurus
V201	ISPGLVETGFA	1	Gallus gallus
V201	ISPGLVETQFA	1	Mus musculus
V201	IAPGLVETEFS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V201	VDPGLVETEFS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y166	SVTHFYSATKY	1	Homo sapiens
Y166	SVVHFYSATKY	1	Gallus gallus
Y166	SVIHFYSATKY	1	Mus musculus
Y166	AETHFYSATKY	1	Bos taurus
Y166	GSI--YCASKF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y166	GSV--YCSTKS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)