mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DHRS11
Gene summary
Basic gene Info.Gene symbolDHRS11
Gene namedehydrogenase/reductase (SDR family) member 11
CytomapUCSC genome browser: 17q12
Type of geneprotein-coding
Descriptiondehydrogenase/reductase SDR family member 11short chain dehydrogenase/reductase family 24C, member 1short-chain dehydrogenase/reductase
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000278535
HPRD : 08331
Vega : OTTHUMG00000188442
ProteinUniProt: Q6UWP2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DHRS11
BioGPS: 79154
PathwayNCI Pathway Interaction Database: DHRS11
Pathway Commons: DHRS11
ContextiHOP: DHRS11
ligand binding site mutation search in PubMed: DHRS11
UCL Cancer Institute: DHRS11
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for DHRS11

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for DHRS11
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DHRS11 from PDB

Differential gene expression and gene-gene network for DHRS11
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DHRS11 and the right PPI network was created from samples without mutations in the LBS of DHRS11. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for DHRS11
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for DHRS11
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DHRS11 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of DHRS11
Multiple alignments for Q6UWP2 in multiple species
LBSAA sequence# speciesSpecies
A42KVVGCARTVGN3Homo sapiens, Mus musculus, Bos taurus
A42KVVGCARSVDK1Gallus gallus
A42KLILAARRLEK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A42KLILAARRFST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A98ICINNAGLA-R2Homo sapiens, Bos taurus
A98VCINNAGLA-R1Gallus gallus
A98ICINNAGMA-R1Mus musculus
A98ILVNNAGKALG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A98VLINNAGLALG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C69IPY-RCDLSNE3Homo sapiens, Mus musculus, Bos taurus
C69IPY-KCDLSNE1Gallus gallus
C69VHVAQLDITQA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C69LPL-KLDVSDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D70PY-RCDLSNEE3Homo sapiens, Mus musculus, Bos taurus
D70PY-KCDLSNEE1Gallus gallus
D70HVAQLDITQAE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D70PL-KLDVSDLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F205VVETQFAFKLH2Homo sapiens, Bos taurus
F205LVETGFAFKLH1Gallus gallus
F205LVETQFAFKLH1Mus musculus
F205LVETEFSLVRY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F205LVETEFSVVRF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G18LALVTGASGGI3Homo sapiens, Mus musculus, Bos taurus
G18VALVTGASVGI1Gallus gallus
G18TVLITGASAGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G18TILITGASSGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G199TCISPGVVETQ2Homo sapiens, Bos taurus
G199TCISPGLVETG1Gallus gallus
G199TCISPGLVETQ1Mus musculus
G199ILIAPGLVETE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G199MEVDPGLVETE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G21VTGASGGIGAA3Homo sapiens, Mus musculus, Bos taurus
G21VTGASVGIGAA1Gallus gallus
G21ITGASAGIGKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G21ITGASSGIGKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G22TGASGGIGAAV3Homo sapiens, Mus musculus, Bos taurus
G22TGASVGIGAAV1Gallus gallus
G22TGASAGIGKAT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G22TGASSGIGKST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G99CINNAGLA-RP3Homo sapiens, Gallus gallus, Bos taurus
G99CINNAGMA-RP1Mus musculus
G99LVNNAGKALGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G99LINNAGLALGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I149GHIININSMCG2Mus musculus, Bos taurus
I149GHIININSMSG1Homo sapiens
I149GHIININSMNG1Gallus gallus
I149GDIVNLGSIAG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I149GDILNVGSIAG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I23GASGGIGAAVA3Homo sapiens, Mus musculus, Bos taurus
I23GASVGIGAAVA1Gallus gallus
I23GASAGIGKATA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I23GASSGIGKSTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K170FYSATKYAVTA4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
K170-YCASKFAVGA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K170-YCSTKSALAQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K208TQFAFKLHDKD3Homo sapiens, Mus musculus, Bos taurus
K208TGFAFKLHDND1Gallus gallus
K208TEFSLVRYRGN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K208TEFSVVRFHGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L71Y-RCDLSNEED3Homo sapiens, Mus musculus, Bos taurus
L71Y-KCDLSNEEE1Gallus gallus
L71VAQLDITQAEK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L71L-KLDVSDLKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N150HIININSMCGH2Mus musculus, Bos taurus
N150HIININSMSGH1Homo sapiens
N150HIININSMNGH1Gallus gallus
N150DIVNLGSIAGR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N150DILNVGSIAGR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N97DICINNAGLA-2Homo sapiens, Bos taurus
N97DVCINNAGLA-1Gallus gallus
N97DICINNAGMA-1Mus musculus
N97DILVNNAGKAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N97DVLINNAGLAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P198ATCISPGVVET2Homo sapiens, Bos taurus
P198ATCISPGLVET2Gallus gallus, Mus musculus
P198VILIAPGLVET1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P198IMEVDPGLVET1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q204GVVETQFAFKL2Homo sapiens, Bos taurus
Q204GLVETGFAFKL1Gallus gallus
Q204GLVETQFAFKL1Mus musculus
Q204GLVETEFSLVR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q204GLVETEFSVVR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R43VVGCARTVGNI3Homo sapiens, Mus musculus, Bos taurus
R43VVGCARSVDKI1Gallus gallus
R43LILAARRLEKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R43LILAARRFSTV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S151IININSMCGHR2Mus musculus, Bos taurus
S151IININSMSGHR1Homo sapiens
S151IININSMNGHS1Gallus gallus
S151IVNLGSIAGRD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S151ILNVGSIAGRE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S20LVTGASGGIGA3Homo sapiens, Mus musculus, Bos taurus
S20LVTGASVGIGA1Gallus gallus
S20LITGASAGIGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S20LITGASSGIGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T203PGVVETQFAFK2Homo sapiens, Bos taurus
T203PGLVETGFAFK1Gallus gallus
T203PGLVETQFAFK1Mus musculus
T203PGLVETEFSLV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T203PGLVETEFSVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T44VGCARTVGNIE3Homo sapiens, Mus musculus, Bos taurus
T44VGCARSVDKIE1Gallus gallus
T44ILAARRLEKLE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T44ILAARRFSTVE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V120KDMFNVNVLAL2Homo sapiens, Mus musculus
V120RTMIDVNVMAV1Gallus gallus
V120KEMFNVNVLAL1Bos taurus
V120QDVFDTNVTAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V120VTMITTNVLGM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V200CISPGVVETQF2Homo sapiens, Bos taurus
V200CISPGLVETGF1Gallus gallus
V200CISPGLVETQF1Mus musculus
V200LIAPGLVETEF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V200EVDPGLVETEF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V201ISPGVVETQFA2Homo sapiens, Bos taurus
V201ISPGLVETGFA1Gallus gallus
V201ISPGLVETQFA1Mus musculus
V201IAPGLVETEFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V201VDPGLVETEFS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y166SVTHFYSATKY1Homo sapiens
Y166SVVHFYSATKY1Gallus gallus
Y166SVIHFYSATKY1Mus musculus
Y166AETHFYSATKY1Bos taurus
Y166GSI--YCASKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y166GSV--YCSTKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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