mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL24
Gene summary
Basic gene Info.Gene symbolMRPL24
Gene namemitochondrial ribosomal protein L24
CytomapUCSC genome browser: 1q23.1
Type of geneprotein-coding
Description39S ribosomal protein L24, mitochondrial
Modification date20141207
dbXrefs MIM : 611836
Ensembl : ENSG00000143314
HPRD : 14749
Vega : OTTHUMG00000041296
ProteinUniProt: Q96A35
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL24
BioGPS: 79590
PathwayNCI Pathway Interaction Database: MRPL24
Pathway Commons: MRPL24
ContextiHOP: MRPL24
ligand binding site mutation search in PubMed: MRPL24
UCL Cancer Institute: MRPL24
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for MRPL24

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MRPL24
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL24 from PDB

Differential gene expression and gene-gene network for MRPL24
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL24 and the right PPI network was created from samples without mutations in the LBS of MRPL24. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MRPL24
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MRPL24
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL24 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7yVK34 R42

Conservation information for LBS of MRPL24
Multiple alignments for Q96A35 in multiple species
LBSAA sequence# speciesSpecies
A113MIPSEAPL--L2Homo sapiens, Rattus norvegicus
A113LRWQEQPLSVS1Caenorhabditis elegans
A113IIKSEAPLH-V1Drosophila melanogaster
A113YLASEAPL--L1Danio rerio
A113MVPSEAPL--L1Bos taurus
A113MIASEAPL--L1Mus musculus
A30----IADKRKN2Mus musculus, Rattus norvegicus
A30----VADKRKN1Homo sapiens
A30SDKYFSAQLSN1Caenorhabditis elegans
A30----GQFRQQN1Drosophila melanogaster
A30----IAARRLN1Danio rerio
A30----LADKKKN1Bos taurus
G22---RYGMS---4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G22---RFGAPDIK1Caenorhabditis elegans
G22KRFRYTTN---1Drosophila melanogaster
G22---RYGTN---1Danio rerio
H18---PPHY----1Homo sapiens
H18RHMPSAYVERT1Caenorhabditis elegans
H18---PKEYIERS1Drosophila melanogaster
H18---PHGY----1Danio rerio
H18---PPNY----1Bos taurus
H18---SPFY----1Mus musculus
H18---SPHY----1Rattus norvegicus
H94EGLNTHYRYVG2Danio rerio, Bos taurus
H94EGLNTHYRYIG2Mus musculus, Rattus norvegicus
H94GGLNTHYRYIG1Homo sapiens
H94DGLHTKLGEDM1Caenorhabditis elegans
H94EGLNWHYRKVG1Drosophila melanogaster
K34IADKRKNPPWS2Mus musculus, Rattus norvegicus
K34VADKRKNPPWI1Homo sapiens
K34FSAQLSNQYFN1Caenorhabditis elegans
K34GQFRQQNMPGT1Drosophila melanogaster
K34IAARRLNPPGK1Danio rerio
M23--RYGMS----4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M23--RFGAPDIKM1Caenorhabditis elegans
M23RFRYTTN----1Drosophila melanogaster
M23--RYGTN----1Danio rerio
R20-----RYGMS-4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R20-----RFGAPD1Caenorhabditis elegans
R20ERKRFRYTTN-1Drosophila melanogaster
R20-----RYGTN-1Danio rerio
R33-IADKRKNPPW2Mus musculus, Rattus norvegicus
R33-VADKRKNPPW1Homo sapiens
R33YFSAQLSNQYF1Caenorhabditis elegans
R33-GQFRQQNMPG1Drosophila melanogaster
R33-IAARRLNPPG1Danio rerio
R33-LADKKKNPPG1Bos taurus
R40NPPWSRRRPVV2Mus musculus, Rattus norvegicus
R40NPPWIRRRPVV1Homo sapiens
R40NQYFNLRRPKS1Caenorhabditis elegans
R40NMPGTVRRKVL1Drosophila melanogaster
R40NPPGKRRRKVF1Danio rerio
R41PPWSRRRPVVV2Mus musculus, Rattus norvegicus
R41PPWIRRRPVVV1Homo sapiens
R41QYFNLRRPKS-1Caenorhabditis elegans
R41MPGTVRRKVLV1Drosophila melanogaster
R41PPGKRRRKVFV1Danio rerio
R42PWSRRRPVVVE2Mus musculus, Rattus norvegicus
R42PWIRRRPVVVE1Homo sapiens
R42YFNLRRPKS-E1Caenorhabditis elegans
R42PGTVRRKVLVE1Drosophila melanogaster
R42PGKRRRKVFVE1Danio rerio
R83QVIRQRNWVVV2Homo sapiens, Bos taurus
R83QVVRQRNWVVL2Mus musculus, Rattus norvegicus
R83TTSRDSSDVIV1Caenorhabditis elegans
R83QVIPERNWVIV1Drosophila melanogaster
R83QVIRARNWVIL1Danio rerio
R96LNTHYRYIGRT2Mus musculus, Rattus norvegicus
R96LNTHYRYIGKT1Homo sapiens
R96LHTKLGEDMEG1Caenorhabditis elegans
R96LNWHYRKVGGE1Drosophila melanogaster
R96LNTHYRYVGRS1Danio rerio
S111-TMIPSEAPL-2Homo sapiens, Rattus norvegicus
S111KTLRWQEQPLS1Caenorhabditis elegans
S111-IIIKSEAPLH1Drosophila melanogaster
S111-TYLASEAPL-1Danio rerio
S111-TMVPSEAPL-1Bos taurus
S111-TMIASEAPL-1Mus musculus
S24-RYGMS-----4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S24-RFGAPDIKMY1Caenorhabditis elegans
S24FRYTTN-----1Drosophila melanogaster
S24-RYGTN-----1Danio rerio
W85VRQRNWVVLEG2Mus musculus, Rattus norvegicus
W85IRQRNWVVVGG1Homo sapiens
W85SRDSSDVIVDG1Caenorhabditis elegans
W85IPERNWVIVEG1Drosophila melanogaster
W85IRARNWVILEG1Danio rerio

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