mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for E2F8
Gene summary
Basic gene Info.Gene symbolE2F8
Gene nameE2F transcription factor 8
CytomapUCSC genome browser: 11p15.1
Type of geneprotein-coding
DescriptionE2F family member 8transcription factor E2F8
Modification date20141207
dbXrefs MIM : 612047
Ensembl : ENSG00000129173
HPRD : 10981
Vega : OTTHUMG00000166102
ProteinUniProt: A0AVK6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_E2F8
BioGPS: 79733
PathwayNCI Pathway Interaction Database: E2F8
Pathway Commons: E2F8
ContextiHOP: E2F8
ligand binding site mutation search in PubMed: E2F8
UCL Cancer Institute: E2F8
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0000122negative regulation of transcription from RNA polymerase II promoter16179649

Ligand binding site mutations for E2F8
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for E2F8
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for E2F8 from PDB

Differential gene expression and gene-gene network for E2F8
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of E2F8 and the right PPI network was created from samples without mutations in the LBS of E2F8. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for E2F8
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for E2F8
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of E2F8 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids4yo2AR154 Y158 N162 K264 R313
NUCNucleic Acids4yo2AR313 Y316

Conservation information for LBS of E2F8
Multiple alignments for A0AVK6 in multiple species
LBSAA sequence# speciesSpecies
E153EELNVERRRIY3Homo sapiens, Mus musculus, Bos taurus
K114SQPSRKEKSLG3Homo sapiens, Mus musculus, Bos taurus
K116PSRKEKSLGLL3Homo sapiens, Mus musculus, Bos taurus
K175VSRLAKNRYTW3Homo sapiens, Mus musculus, Bos taurus
K264NSRKDKSLRVM2Homo sapiens, Mus musculus
K264NSRKDKSLKVM1Bos taurus
K307DLDKSKFKTKI1Homo sapiens
K307DLDKSKYKTKI1Mus musculus
K307DLDRSKFKTKI1Bos taurus
L118RKEKSLGLLCH3Homo sapiens, Mus musculus, Bos taurus
L266RKDKSLRVMSQ2Homo sapiens, Mus musculus
L266RKDKSLKVMSQ1Bos taurus
N162IYDIVNVLESL3Homo sapiens, Mus musculus, Bos taurus
N176SRLAKNRYTWH3Homo sapiens, Mus musculus, Bos taurus
N320LYDIANVLSSL3Homo sapiens, Mus musculus, Bos taurus
R113KSQPSRKEKSL3Homo sapiens, Mus musculus, Bos taurus
R154ELNVERRRIYD3Homo sapiens, Mus musculus, Bos taurus
R155LNVERRRIYDI3Homo sapiens, Mus musculus, Bos taurus
R156NVERRRIYDIV3Homo sapiens, Mus musculus, Bos taurus
R172LHMVSRLAKNR3Homo sapiens, Mus musculus, Bos taurus
R267KDKSLRVMSQK2Homo sapiens, Mus musculus
R267KDKSLKVMSQK1Bos taurus
R313FKTKIRRLYDI2Homo sapiens, Bos taurus
R313YKTKIRRLYDI1Mus musculus
R314KTKIRRLYDIA3Homo sapiens, Mus musculus, Bos taurus
S112EKSQPSRKEKS3Homo sapiens, Mus musculus, Bos taurus
S117SRKEKSLGLLC3Homo sapiens, Mus musculus, Bos taurus
T310KSKFKTKIRRL1Homo sapiens
T310KSKYKTKIRRL1Mus musculus
T310RSKFKTKIRRL1Bos taurus
V333IKKVHVTEERG3Homo sapiens, Mus musculus, Bos taurus
Y158ERRRIYDIVNV3Homo sapiens, Mus musculus, Bos taurus
Y316KIRRLYDIANV3Homo sapiens, Mus musculus, Bos taurus

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