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mutLBSgeneDB |
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| Gene summary for CAMKMT |
 Gene summary |
| Basic gene Info. | Gene symbol | CAMKMT |
| Gene name | calmodulin-lysine N-methyltransferase | |
| Synonyms | C2orf34|CLNMT|CaM KMT|Cam|KMT | |
| Cytomap | UCSC genome browser: 2p21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_024766.4, | |
| Description | - | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609559 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000143919 | ||
| HPRD : 08028 | ||
| Vega : OTTHUMG00000128761 | ||
| Protein | UniProt: Q7Z624 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CAMKMT | |
| BioGPS: 79823 | ||
| Pathway | NCI Pathway Interaction Database: CAMKMT | |
| KEGG: CAMKMT | ||
| REACTOME: CAMKMT | ||
| Pathway Commons: CAMKMT | ||
| Context | iHOP: CAMKMT | |
| ligand binding site mutation search in PubMed: CAMKMT | ||
| UCL Cancer Institute: CAMKMT | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CAMKMT |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R211 | R211Q | LUAD | 1 | Y239 | Y239C | UCEC | 1 | A231 | M229V | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CAMKMT |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R211 | R211Q | -1.4002613 | Y239 | Y239C | -1.2465868 | A231 | M229V | -0.99617009 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CAMKMT from PDB |
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| Differential gene expression and gene-gene network for CAMKMT |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CAMKMT |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CAMKMT |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CAMKMT go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SAH | S-ADENOSYL-L-HOMOCYSTEINE | 4pwy | A | R211 A231 Y239 |
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| Conservation information for LBS of CAMKMT |
| Multiple alignments for Q7Z624 in multiple species |
| LBS | AA sequence | # species | Species | A231 | DIVMCADCLFL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D178 | EVLLTDGNEKA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D213 | CVLRWDNETDV | 1 | Homo sapiens | D213 | RVLRWDNETDV | 1 | Mus musculus | D213 | CVLRWDNKTDV | 1 | Rattus norvegicus | D232 | IVMCADCLFLD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E131 | CIWPSEEVLAY | 2 | Homo sapiens, Rattus norvegicus | E131 | CIWPSEEVLAH | 1 | Mus musculus | F235 | CADCLFLDQYR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G154 | AVCELGGGMTC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G156 | CELGGGMTCLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G179 | VLLTDGNEKAI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L210 | ISSCVLRWDNE | 1 | Homo sapiens | L210 | ISSRVLRWDNE | 1 | Mus musculus | L210 | ISSCVLRWDNK | 1 | Rattus norvegicus | L236 | ADCLFLDQYRA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N180 | LLTDGNEKAIR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R211 | SSCVLRWDNET | 1 | Homo sapiens | R211 | SSRVLRWDNET | 1 | Mus musculus | R211 | SSCVLRWDNKT | 1 | Rattus norvegicus | W128 | GNVCIWPSEEV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W212 | SCVLRWDNETD | 1 | Homo sapiens | W212 | SRVLRWDNETD | 1 | Mus musculus | W212 | SCVLRWDNKTD | 1 | Rattus norvegicus | Y239 | LFLDQYRASLV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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