mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for NAA40
Gene summary
Basic gene Info.Gene symbolNAA40
Gene nameN(alpha)-acetyltransferase 40, NatD catalytic subunit
SynonymsNAT11|PATT1
CytomapUCSC genome browser: 11q13.1
Type of geneprotein-coding
RefGenesNM_001300800.1,
NM_024771.3,
DescriptionN(alpha)-acetyltransferase 40, NatD catalytic subunit, homologN-acetyltransferase 11 (GCN5-related, putative)N-alpha acetyl transferase 40N-alpha-acetyltransferase 40N-alpha-acetyltransferase 40, NatD catalytic subunitnatD catalytic subunit
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000110583
HPRD : 07838
Vega : OTTHUMG00000167784
ProteinUniProt: Q86UY6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NAA40
BioGPS: 79829
PathwayNCI Pathway Interaction Database: NAA40
KEGG: NAA40
REACTOME: NAA40
Pathway Commons: NAA40
ContextiHOP: NAA40
ligand binding site mutation search in PubMed: NAA40
UCL Cancer Institute: NAA40
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for NAA40
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S197P199LSKCM1
R147R147WTHCA1
K97E96DUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for NAA40
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K97E96D-1.2609867
R147R147W-0.77296247
S197P199L-0.35356567
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for NAA40 from PDB

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Differential gene expression and gene-gene network for NAA40
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of NAA40 and the right PPI network was created from samples without mutations in the LBS of NAA40. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for NAA40
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for NAA40
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of NAA40 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (SER,GLY,ARG,GLY,LYS,NH2)4u9wDK97 S197
ACOACETYL COENZYME *A4u9vBR147
COACOENZYME A4u9wAR147
COACOENZYME A4u9wBR147
COACOENZYME A4u9wCR147
COACOENZYME A4u9wDR147
IIIPeptide ligand (SER,GLY,ARG,GLY,LYS,NH2)4u9wAS197
IIIPeptide ligand (SER,GLY,ARG,GLY,LYS,NH2)4u9wBS197


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Conservation information for LBS of NAA40
Multiple alignments for Q86UY6 in multiple species
LBSAA sequence# speciesSpecies
A182KHNHGAYQFFR3Homo sapiens, Mus musculus, Danio rerio
A189QFFREALQFEI3Homo sapiens, Mus musculus, Danio rerio
D127SHFRFDVECGD3Homo sapiens, Mus musculus, Danio rerio
E100REKREEMTDDR2Homo sapiens, Mus musculus
E100REKREEMKDER1Danio rerio
E129FRFDVECGDEV3Homo sapiens, Mus musculus, Danio rerio
E139VLYCYEVQLES3Homo sapiens, Mus musculus, Danio rerio
F185HGAYQFFREAL3Homo sapiens, Mus musculus, Danio rerio
F186GAYQFFREALQ3Homo sapiens, Mus musculus, Danio rerio
G150KVRRKGLGKFL3Homo sapiens, Mus musculus, Danio rerio
G152RRKGLGKFLIQ3Homo sapiens, Mus musculus, Danio rerio
G181FKHNHGAYQFF3Homo sapiens, Mus musculus, Danio rerio
I213DCSYEILSRRT3Homo sapiens, Mus musculus, Danio rerio
K149SKVRRKGLGKF3Homo sapiens, Mus musculus, Danio rerio
K153RKGLGKFLIQI3Homo sapiens, Mus musculus, Danio rerio
K97WKDREKREEMT2Homo sapiens, Mus musculus
K97WKEREKREEMK1Danio rerio
L142CYEVQLESKVR3Homo sapiens, Mus musculus, Danio rerio
M81LTKTNMQTMYE2Homo sapiens, Mus musculus
M81LTRANMQTLYE1Danio rerio
N179TVFKHNHGAYQ3Homo sapiens, Mus musculus, Danio rerio
Q141YCYEVQLESKV3Homo sapiens, Mus musculus, Danio rerio
Q184NHGAYQFFREA3Homo sapiens, Mus musculus, Danio rerio
R147LESKVRRKGLG3Homo sapiens, Mus musculus, Danio rerio
R148ESKVRRKGLGK3Homo sapiens, Mus musculus, Danio rerio
S197FEIDDSSPSMS2Homo sapiens, Mus musculus
S197FEIDETSPSMS1Danio rerio
T174KKVMLTVFKHN3Homo sapiens, Mus musculus, Danio rerio
V128HFRFDVECGDE3Homo sapiens, Mus musculus, Danio rerio
V140LYCYEVQLESK3Homo sapiens, Mus musculus, Danio rerio
W90YEQSEWGWKDR2Homo sapiens, Mus musculus
W90YEQSEWGWKER1Danio rerio
Y136GDEVLYCYEVQ3Homo sapiens, Mus musculus, Danio rerio
Y138EVLYCYEVQLE3Homo sapiens, Mus musculus, Danio rerio
Y211GEDCSYEILSR3Homo sapiens, Mus musculus, Danio rerio
Y85NMQTMYEQSEW2Homo sapiens, Mus musculus
Y85NMQTLYEQSEW1Danio rerio


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