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mutLBSgeneDB |
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| Gene summary for NAA40 |
 Gene summary |
| Basic gene Info. | Gene symbol | NAA40 |
| Gene name | N(alpha)-acetyltransferase 40, NatD catalytic subunit | |
| Synonyms | NAT11|PATT1 | |
| Cytomap | UCSC genome browser: 11q13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001300800.1, NM_024771.3, | |
| Description | N(alpha)-acetyltransferase 40, NatD catalytic subunit, homologN-acetyltransferase 11 (GCN5-related, putative)N-alpha acetyl transferase 40N-alpha-acetyltransferase 40N-alpha-acetyltransferase 40, NatD catalytic subunitnatD catalytic subunit | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000110583 | ||
| HPRD : 07838 | ||
| Vega : OTTHUMG00000167784 | ||
| Protein | UniProt: Q86UY6 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NAA40 | |
| BioGPS: 79829 | ||
| Pathway | NCI Pathway Interaction Database: NAA40 | |
| KEGG: NAA40 | ||
| REACTOME: NAA40 | ||
| Pathway Commons: NAA40 | ||
| Context | iHOP: NAA40 | |
| ligand binding site mutation search in PubMed: NAA40 | ||
| UCL Cancer Institute: NAA40 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for NAA40 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S197 | P199L | SKCM | 1 | R147 | R147W | THCA | 1 | K97 | E96D | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for NAA40 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K97 | E96D | -1.2609867 | R147 | R147W | -0.77296247 | S197 | P199L | -0.35356567 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for NAA40 from PDB |
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| Differential gene expression and gene-gene network for NAA40 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for NAA40 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for NAA40 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of NAA40 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (SER,GLY,ARG,GLY,LYS,NH2) | 4u9w | D | K97 S197 | ACO | ACETYL COENZYME *A | 4u9v | B | R147 | COA | COENZYME A | 4u9w | A | R147 | COA | COENZYME A | 4u9w | B | R147 | COA | COENZYME A | 4u9w | C | R147 | COA | COENZYME A | 4u9w | D | R147 | III | Peptide ligand (SER,GLY,ARG,GLY,LYS,NH2) | 4u9w | A | S197 | III | Peptide ligand (SER,GLY,ARG,GLY,LYS,NH2) | 4u9w | B | S197 |
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| Conservation information for LBS of NAA40 |
| Multiple alignments for Q86UY6 in multiple species |
| LBS | AA sequence | # species | Species | A182 | KHNHGAYQFFR | 3 | Homo sapiens, Mus musculus, Danio rerio | A189 | QFFREALQFEI | 3 | Homo sapiens, Mus musculus, Danio rerio | D127 | SHFRFDVECGD | 3 | Homo sapiens, Mus musculus, Danio rerio | E100 | REKREEMTDDR | 2 | Homo sapiens, Mus musculus | E100 | REKREEMKDER | 1 | Danio rerio | E129 | FRFDVECGDEV | 3 | Homo sapiens, Mus musculus, Danio rerio | E139 | VLYCYEVQLES | 3 | Homo sapiens, Mus musculus, Danio rerio | F185 | HGAYQFFREAL | 3 | Homo sapiens, Mus musculus, Danio rerio | F186 | GAYQFFREALQ | 3 | Homo sapiens, Mus musculus, Danio rerio | G150 | KVRRKGLGKFL | 3 | Homo sapiens, Mus musculus, Danio rerio | G152 | RRKGLGKFLIQ | 3 | Homo sapiens, Mus musculus, Danio rerio | G181 | FKHNHGAYQFF | 3 | Homo sapiens, Mus musculus, Danio rerio | I213 | DCSYEILSRRT | 3 | Homo sapiens, Mus musculus, Danio rerio | K149 | SKVRRKGLGKF | 3 | Homo sapiens, Mus musculus, Danio rerio | K153 | RKGLGKFLIQI | 3 | Homo sapiens, Mus musculus, Danio rerio | K97 | WKDREKREEMT | 2 | Homo sapiens, Mus musculus | K97 | WKEREKREEMK | 1 | Danio rerio | L142 | CYEVQLESKVR | 3 | Homo sapiens, Mus musculus, Danio rerio | M81 | LTKTNMQTMYE | 2 | Homo sapiens, Mus musculus | M81 | LTRANMQTLYE | 1 | Danio rerio | N179 | TVFKHNHGAYQ | 3 | Homo sapiens, Mus musculus, Danio rerio | Q141 | YCYEVQLESKV | 3 | Homo sapiens, Mus musculus, Danio rerio | Q184 | NHGAYQFFREA | 3 | Homo sapiens, Mus musculus, Danio rerio | R147 | LESKVRRKGLG | 3 | Homo sapiens, Mus musculus, Danio rerio | R148 | ESKVRRKGLGK | 3 | Homo sapiens, Mus musculus, Danio rerio | S197 | FEIDDSSPSMS | 2 | Homo sapiens, Mus musculus | S197 | FEIDETSPSMS | 1 | Danio rerio | T174 | KKVMLTVFKHN | 3 | Homo sapiens, Mus musculus, Danio rerio | V128 | HFRFDVECGDE | 3 | Homo sapiens, Mus musculus, Danio rerio | V140 | LYCYEVQLESK | 3 | Homo sapiens, Mus musculus, Danio rerio | W90 | YEQSEWGWKDR | 2 | Homo sapiens, Mus musculus | W90 | YEQSEWGWKER | 1 | Danio rerio | Y136 | GDEVLYCYEVQ | 3 | Homo sapiens, Mus musculus, Danio rerio | Y138 | EVLYCYEVQLE | 3 | Homo sapiens, Mus musculus, Danio rerio | Y211 | GEDCSYEILSR | 3 | Homo sapiens, Mus musculus, Danio rerio | Y85 | NMQTMYEQSEW | 2 | Homo sapiens, Mus musculus | Y85 | NMQTLYEQSEW | 1 | Danio rerio |
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