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mutLBSgeneDB |
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| Gene summary for NUDT18 |
 Gene summary |
| Basic gene Info. | Gene symbol | NUDT18 |
| Gene name | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | |
| Synonyms | MTH3 | |
| Cytomap | UCSC genome browser: 8p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_024815.3, | |
| Description | 2-hydroxy-dADP phosphatase7,8-dihydro-8-oxoguanine phosphatase8-oxo-dGDP phosphatase NUDT18mutT homolog 3mutT human homolog 3nucleoside diphosphate-linked moiety X motif 18nudix motif 18 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615791 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000275074 | ||
| HPRD : 07992 | ||
| Vega : OTTHUMG00000163774 | ||
| Protein | UniProt: Q6ZVK8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NUDT18 | |
| BioGPS: 79873 | ||
| Pathway | NCI Pathway Interaction Database: NUDT18 | |
| KEGG: NUDT18 | ||
| REACTOME: NUDT18 | ||
| Pathway Commons: NUDT18 | ||
| Context | iHOP: NUDT18 | |
| ligand binding site mutation search in PubMed: NUDT18 | ||
| UCL Cancer Institute: NUDT18 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0046057 | dADP catabolic process | 22556419 | GO:0046067 | dGDP catabolic process | 22556419 | GO:0046712 | GDP catabolic process | 22556419 |
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| Ligand binding site mutations for NUDT18 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V57 | V57A | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for NUDT18 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V57 | V57A | -1.8857259 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for NUDT18 from PDB |
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| Differential gene expression and gene-gene network for NUDT18 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for NUDT18 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for NUDT18 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of NUDT18 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 4hvy | A | V57 |
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| Conservation information for LBS of NUDT18 |
| Multiple alignments for Q6ZVK8 in multiple species |
| LBS | AA sequence | # species | Species | A48 | CYVVLAVFLNE | 2 | Mus musculus, Rattus norvegicus | A48 | CYVVLAVFLSE | 1 | Homo sapiens | A48 | CYIVGAVIFNS | 1 | Danio rerio | F50 | VVLAVFLNEQD | 2 | Mus musculus, Rattus norvegicus | F50 | VVLAVFLSEQD | 1 | Homo sapiens | F50 | IVGAVIFNSKE | 1 | Danio rerio | L58 | EQDEVLMIQEA | 2 | Mus musculus, Rattus norvegicus | L58 | EQDEVLLIQEA | 1 | Homo sapiens | L58 | SKEEVLMVQEA | 1 | Danio rerio | L73 | RGTWYLPAGRM | 2 | Mus musculus, Rattus norvegicus | L73 | RGSWYLPAGRM | 1 | Homo sapiens | L73 | YGRWYLPAGRM | 1 | Danio rerio | P74 | GTWYLPAGRME | 2 | Mus musculus, Rattus norvegicus | P74 | GSWYLPAGRME | 1 | Homo sapiens | P74 | GRWYLPAGRME | 1 | Danio rerio | V49 | YVVLAVFLNEQ | 2 | Mus musculus, Rattus norvegicus | V49 | YVVLAVFLSEQ | 1 | Homo sapiens | V49 | YIVGAVIFNSK | 1 | Danio rerio | V57 | NEQDEVLMIQE | 2 | Mus musculus, Rattus norvegicus | V57 | SEQDEVLLIQE | 1 | Homo sapiens | V57 | NSKEEVLMVQE | 1 | Danio rerio |
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