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mutLBSgeneDB |
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| Gene summary for TUSC3 |
 Gene summary |
| Basic gene Info. | Gene symbol | TUSC3 |
| Gene name | tumor suppressor candidate 3 | |
| Synonyms | D8S1992|M33|MRT22|MRT7|N33|OST3A | |
| Cytomap | UCSC genome browser: 8p22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006765.3, NM_178234.2, | |
| Description | Putative prostate cancer tumor suppressormagnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog A | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 601385 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000104723 | ||
| HPRD : 03228 | ||
| Vega : OTTHUMG00000094803 | ||
| Protein | UniProt: Q13454 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TUSC3 | |
| BioGPS: 7991 | ||
| Pathway | NCI Pathway Interaction Database: TUSC3 | |
| KEGG: TUSC3 | ||
| REACTOME: TUSC3 | ||
| Pathway Commons: TUSC3 | ||
| Context | iHOP: TUSC3 | |
| ligand binding site mutation search in PubMed: TUSC3 | ||
| UCL Cancer Institute: TUSC3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for TUSC3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R97 | R97W | COAD | 1 | D134 | D134E | SKCM | 1 | N146 | M145I | UCEC | 1 | D134 | D134V | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TUSC3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R97 | R97W | -1.2168684 | D134 | D134E | -0.85676852 | D134 | D134V | -0.78938976 | N146 | M145I | -0.58727242 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TUSC3 from PDB |
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| Differential gene expression and gene-gene network for TUSC3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TUSC3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TUSC3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TUSC3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of TUSC3 |
| Multiple alignments for Q13454 in multiple species |
| LBS | AA sequence | # species | Species | A148 | LNMNSAPTFMH | 2 | Homo sapiens, Mus musculus | A148 | MNLNTAPILYH | 1 | Caenorhabditis elegans | A148 | LNINSAPTFMH | 1 | Bos taurus | A148 | FQLNNVPRLFI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A148 | FSIESVPNFWI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A92 | IVMFTALQPQR | 3 | Homo sapiens, Bos taurus, Mus musculus | A92 | IVMFTALSPGV | 1 | Caenorhabditis elegans | A92 | VALFTATAPEI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A92 | VALFSADSSTM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D134 | SMVDYDEG--- | 1 | Homo sapiens | D134 | GIVDYEDA--- | 1 | Caenorhabditis elegans | D134 | SKVDYDEG--- | 1 | Bos taurus | D134 | GMVDYDEG--- | 1 | Mus musculus | D134 | TKVNLEDPSKT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D134 | TYADFGKN--- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F140 | --TDVFQQLNM | 2 | Homo sapiens, Mus musculus | F140 | --PQIFQQMNL | 1 | Caenorhabditis elegans | F140 | --TDIFQQLNI | 1 | Bos taurus | F140 | TIPKAFQFFQL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F140 | --KNLFQDFSI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N146 | QQLNMNSAPTF | 2 | Homo sapiens, Mus musculus | N146 | QQMNLNTAPIL | 1 | Caenorhabditis elegans | N146 | QQLNINSAPTF | 1 | Bos taurus | N146 | QFFQLNNVPRL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N146 | QDFSIESVPNF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R97 | ALQPQRQCSVC | 3 | Homo sapiens, Bos taurus, Mus musculus | R97 | ALSPGVQCPIC | 1 | Caenorhabditis elegans | R97 | ATAPEIGCSLC | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R97 | ADSSTMNCDVC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S147 | QLNMNSAPTFM | 2 | Homo sapiens, Mus musculus | S147 | QMNLNTAPILY | 1 | Caenorhabditis elegans | S147 | QLNINSAPTFM | 1 | Bos taurus | S147 | FFQLNNVPRLF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S147 | DFSIESVPNFW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T137 | G----TDVFQQ | 2 | Homo sapiens, Mus musculus | T137 | A----PQIFQQ | 1 | Caenorhabditis elegans | T137 | G----TDIFQQ | 1 | Bos taurus | T137 | PSKTIPKAFQF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T137 | N----KNLFQD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y133 | FSMVDYDEG-- | 1 | Homo sapiens | Y133 | FGIVDYEDA-- | 1 | Caenorhabditis elegans | Y133 | FSKVDYDEG-- | 1 | Bos taurus | Y133 | FGMVDYDEG-- | 1 | Mus musculus | Y133 | FTKVNLEDPSK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y133 | FTYADFGKN-- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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