mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TUSC3
Gene summary
Basic gene Info.Gene symbolTUSC3
Gene nametumor suppressor candidate 3
CytomapUCSC genome browser: 8p22
Type of geneprotein-coding
DescriptionPutative prostate cancer tumor suppressormagnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog A
Modification date20141219
dbXrefs MIM : 601385
Ensembl : ENSG00000104723
HPRD : 03228
Vega : OTTHUMG00000094803
ProteinUniProt: Q13454
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TUSC3
BioGPS: 7991
PathwayNCI Pathway Interaction Database: TUSC3
Pathway Commons: TUSC3
ContextiHOP: TUSC3
ligand binding site mutation search in PubMed: TUSC3
UCL Cancer Institute: TUSC3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for TUSC3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for TUSC3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TUSC3 from PDB

Differential gene expression and gene-gene network for TUSC3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TUSC3 and the right PPI network was created from samples without mutations in the LBS of TUSC3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for TUSC3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for TUSC3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TUSC3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of TUSC3
Multiple alignments for Q13454 in multiple species
LBSAA sequence# speciesSpecies
A148LNMNSAPTFMH2Homo sapiens, Mus musculus
A148MNLNTAPILYH1Caenorhabditis elegans
A148LNINSAPTFMH1Bos taurus
A148FQLNNVPRLFI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A148FSIESVPNFWI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A92IVMFTALQPQR3Homo sapiens, Bos taurus, Mus musculus
A92IVMFTALSPGV1Caenorhabditis elegans
A92VALFTATAPEI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A92VALFSADSSTM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D134SMVDYDEG---1Homo sapiens
D134GIVDYEDA---1Caenorhabditis elegans
D134SKVDYDEG---1Bos taurus
D134GMVDYDEG---1Mus musculus
D134TKVNLEDPSKT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D134TYADFGKN---1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F140--TDVFQQLNM2Homo sapiens, Mus musculus
F140--PQIFQQMNL1Caenorhabditis elegans
F140--TDIFQQLNI1Bos taurus
F140TIPKAFQFFQL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F140--KNLFQDFSI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N146QQLNMNSAPTF2Homo sapiens, Mus musculus
N146QQMNLNTAPIL1Caenorhabditis elegans
N146QQLNINSAPTF1Bos taurus
N146QFFQLNNVPRL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N146QDFSIESVPNF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R97ALQPQRQCSVC3Homo sapiens, Bos taurus, Mus musculus
R97ALSPGVQCPIC1Caenorhabditis elegans
R97ATAPEIGCSLC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R97ADSSTMNCDVC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S147QLNMNSAPTFM2Homo sapiens, Mus musculus
S147QMNLNTAPILY1Caenorhabditis elegans
S147QLNINSAPTFM1Bos taurus
S147FFQLNNVPRLF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S147DFSIESVPNFW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T137G----TDVFQQ2Homo sapiens, Mus musculus
T137A----PQIFQQ1Caenorhabditis elegans
T137G----TDIFQQ1Bos taurus
T137PSKTIPKAFQF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T137N----KNLFQD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y133FSMVDYDEG--1Homo sapiens
Y133FGIVDYEDA--1Caenorhabditis elegans
Y133FSKVDYDEG--1Bos taurus
Y133FGMVDYDEG--1Mus musculus
Y133FTKVNLEDPSK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y133FTYADFGKN--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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