mutLBSgeneDB |
Gene summary for GLRA3 |
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Basic gene Info. | Gene symbol | GLRA3 |
Gene name | glycine receptor, alpha 3 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 4q34.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001042543.2, NM_006529.3, | |
Description | glycine receptor subunit alpha-3glycine receptor, alpha-3 polypeptideligand gated ion channel | |
Modification date | 20141207 | |
dbXrefs | MIM : 600421 | |
HGNC : HGNC | ||
Ensembl : ENSG00000145451 | ||
HPRD : 02688 | ||
Vega : OTTHUMG00000149816 | ||
Protein | UniProt: O75311 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GLRA3 | |
BioGPS: 8001 | ||
Pathway | NCI Pathway Interaction Database: GLRA3 | |
KEGG: GLRA3 | ||
REACTOME: GLRA3 | ||
Pathway Commons: GLRA3 | ||
Context | iHOP: GLRA3 | |
ligand binding site mutation search in PubMed: GLRA3 | ||
UCL Cancer Institute: GLRA3 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for GLRA3 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | R98 | Q99H | BLCA | 1 | R98 | R98C | COAD | 1 | F240 | C242Y | LUAD | 1 | L160 | L160F | SKCM | 1 | R98 | R98C | SKCM | 1 | R98 | R98C | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for GLRA3 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | L160 | L160F | -1.4543401 | R98 | Q99H | -1.1018772 | R98 | R98C | -0.8710116 | F240 | C242Y | -0.49034464 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for GLRA3 |
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Phenotype information for GLRA3 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for GLRA3 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|nutraceutical|vet_approved | DB00145 | Glycine | Small molecule | ![]() |
Approved|withdrawn | DB00431 | Lindane | Small molecule | ![]() |
Experimental | DB00466 | Picrotoxin | Small molecule | ![]() |
Approved|vet_approved | DB00602 | Ivermectin | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of GLRA3 |
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LBS | AA sequence | # species | Species | E190 | CIMQLESFGYT | 2 | Homo sapiens, Mus musculus | E190 | CNFDLVSYAHT | 1 | Caenorhabditis elegans | F192 | MQLESFGYTMN | 2 | Homo sapiens, Mus musculus | F192 | FDLVSYAHTMN | 1 | Caenorhabditis elegans | F240 | YNTGKFTCIEV | 2 | Homo sapiens, Mus musculus | F240 | TNTGSYGCLRM | 1 | Caenorhabditis elegans | F77 | VTCNIFINSFG | 2 | Homo sapiens, Mus musculus | F77 | VRVNIMIRMLS | 1 | Caenorhabditis elegans | F96 | YRVNIFLRQKW | 2 | Homo sapiens, Mus musculus | F96 | YSIQLTFREQW | 1 | Caenorhabditis elegans | L150 | TTDNKLLRIFK | 2 | Homo sapiens, Mus musculus | L150 | DMENMFLRIYP | 1 | Caenorhabditis elegans | L160 | KNGNVLYSIRL | 2 | Homo sapiens, Mus musculus | L160 | PDGKILYSSRI | 1 | Caenorhabditis elegans | R152 | DNKLLRIFKNG | 2 | Homo sapiens, Mus musculus | R152 | ENMFLRIYPDG | 1 | Caenorhabditis elegans | R98 | VNIFLRQKWND | 2 | Homo sapiens, Mus musculus | R98 | IQLTFREQWID | 1 | Caenorhabditis elegans | T237 | TKHYNTGKFTC | 2 | Homo sapiens, Mus musculus | T237 | TSHTNTGSYGC | 1 | Caenorhabditis elegans | Y235 | YCTKHYNTGKF | 2 | Homo sapiens, Mus musculus | Y235 | DCTSHTNTGSY | 1 | Caenorhabditis elegans |
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