mutLBSgeneDB |
Gene summary for BRD3 |
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Basic gene Info. | Gene symbol | BRD3 |
Gene name | bromodomain containing 3 | |
Synonyms | ORFX|RING3L | |
Cytomap | UCSC genome browser: 9q34 | |
Type of gene | protein-coding | |
RefGenes | NM_007371.3, | |
Description | RING3-like proteinbromodomain-containing 3bromodomain-containing protein 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601541 | |
HGNC : HGNC | ||
Ensembl : ENSG00000169925 | ||
HPRD : 03327 | ||
Vega : OTTHUMG00000021004 | ||
Protein | UniProt: Q15059 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BRD3 | |
BioGPS: 8019 | ||
Pathway | NCI Pathway Interaction Database: BRD3 | |
KEGG: BRD3 | ||
REACTOME: BRD3 | ||
Pathway Commons: BRD3 | ||
Context | iHOP: BRD3 | |
ligand binding site mutation search in PubMed: BRD3 | ||
UCL Cancer Institute: BRD3 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0006357 | regulation of transcription from RNA polymerase II promoter | 18406326 |
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Ligand binding site mutations for BRD3 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | W57 | A56T | GBM | 1 | H395 | H395R | LUAD | 1 | H395 | D394N | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for BRD3 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H395 | D394N | -1.1592449 | W57 | A56T | -0.72291775 | H395 | H395R | -0.6146651 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for BRD3 |
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Phenotype information for BRD3 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for BRD3 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | JQ1 | (6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM | 3s92 | A | H395 | JQ1 | (6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM | 3s91 | A | W57 |
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Conservation information for LBS of BRD3 |
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LBS | AA sequence | # species | Species |
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