mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MLLT10
Gene summary
Basic gene Info.Gene symbolMLLT10
Gene namemyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
SynonymsAF10
CytomapUCSC genome browser: 10p12
Type of geneprotein-coding
RefGenesNM_001195626.1,
NM_001195627.1,NM_001195628.1,NM_001195630.1,NM_004641.3,
NM_001009569.1,
DescriptionALL1-fused gene from chromosome 10 proteinprotein AF-10type I AF10 proteintype III AF10 proteintype IV AF10 protein
Modification date20141207
dbXrefs MIM : 602409
HGNC : HGNC
Ensembl : ENSG00000078403
HPRD : 03874
Vega : OTTHUMG00000017799
ProteinUniProt: P55197
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MLLT10
BioGPS: 8028
PathwayNCI Pathway Interaction Database: MLLT10
KEGG: MLLT10
REACTOME: MLLT10
Pathway Commons: MLLT10
ContextiHOP: MLLT10
ligand binding site mutation search in PubMed: MLLT10
UCL Cancer Institute: MLLT10
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0045944positive regulation of transcription from RNA polymerase II promoter17868029


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Ligand binding site mutations for MLLT10

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C47S48RHNSC1
E179E180KSKCM1
C162Q164HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MLLT10
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E179E180K-1.292656
C162Q164H-0.36072907
C47S48R-0.33802899
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MLLT10 from PDB

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Differential gene expression and gene-gene network for MLLT10
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MLLT10 and the right PPI network was created from samples without mutations in the LBS of MLLT10. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MLLT10
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0023467Leukemia, Myeloid, Acute20Biomarker
umls:C0025286Meningioma1Biomarker, GeneticVariation
umls:C0007134Carcinoma, Renal Cell1Biomarker
umls:C0025202Melanoma1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MLLT10
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MLLT10 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)5dagAC162
ZNZINC(2+)5dahAC162
ZNZINC(2+)5dahBC162
ZNZINC(2+)5dagAC47
ZNZINC(2+)5dahAC47
ZNZINC(2+)5dahBC47
IIIPeptide ligand (LEU,ALA,THR,LYS,ALA,ALA,ARG,LYS,SER)5dahAE179
IIIPeptide ligand (LEU,ALA,THR,LYS,ALA,ALA,ARG,LYS,SER)5dahBE179


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Conservation information for LBS of MLLT10
Multiple alignments for P55197 in multiple species
LBSAA sequence# speciesSpecies


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