mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CPEB4
Gene summary
Basic gene Info.Gene symbolCPEB4
Gene namecytoplasmic polyadenylation element binding protein 4
CytomapUCSC genome browser: 5q21
Type of geneprotein-coding
DescriptionCPE-BP4CPE-binding protein 4cytoplasmic polyadenylation element-binding protein 4hCPEB-4
Modification date20141207
dbXrefs MIM : 610607
Ensembl : ENSG00000113742
HPRD : 16746
Vega : OTTHUMG00000130541
ProteinUniProt: Q17RY0
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CPEB4
BioGPS: 80315
PathwayNCI Pathway Interaction Database: CPEB4
Pathway Commons: CPEB4
ContextiHOP: CPEB4
ligand binding site mutation search in PubMed: CPEB4
UCL Cancer Institute: CPEB4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for CPEB4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CPEB4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CPEB4 from PDB

Differential gene expression and gene-gene network for CPEB4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CPEB4 and the right PPI network was created from samples without mutations in the LBS of CPEB4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CPEB4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CPEB4
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CPEB4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of CPEB4
Multiple alignments for Q17RY0 in multiple species
LBSAA sequence# speciesSpecies
D553SPTIKDKPVQI3Homo sapiens, Danio rerio, Mus musculus
D613CYAGIDTDPEL3Homo sapiens, Danio rerio, Mus musculus
F475YSRKVFVGGLP3Homo sapiens, Danio rerio, Mus musculus
F519PKGYAFLLFQD3Homo sapiens, Danio rerio, Mus musculus
F583PRKTIFVGGVP3Homo sapiens, Danio rerio, Mus musculus
G478KVFVGGLPPDI3Homo sapiens, Danio rerio, Mus musculus
G623LKYPKGAGRVA3Homo sapiens, Danio rerio, Mus musculus
H504IVDWPHKAESK2Homo sapiens, Mus musculus
H504FVDWPHKAESK1Danio rerio
I551VSSPTIKDKPV3Homo sapiens, Danio rerio, Mus musculus
K473ERYSRKVFVGG3Homo sapiens, Danio rerio, Mus musculus
K541IEEDGKLYLCV2Homo sapiens, Mus musculus
K541MEEDGKLYLCV1Danio rerio
K554PTIKDKPVQIR3Homo sapiens, Danio rerio, Mus musculus
K622ELKYPKGAGRV3Homo sapiens, Danio rerio, Mus musculus
K658KRVEVKPYVLD3Homo sapiens, Danio rerio, Mus musculus
P481VGGLPPDIDED3Homo sapiens, Danio rerio, Mus musculus
P503LIVDWPHKAES2Homo sapiens, Mus musculus
P503LFVDWPHKAES1Danio rerio
P555TIKDKPVQIRP3Homo sapiens, Danio rerio, Mus musculus
P621PELKYPKGAGR3Homo sapiens, Danio rerio, Mus musculus
Q557KDKPVQIRPWN3Homo sapiens, Danio rerio, Mus musculus
R559KPVQIRPWNLS2Homo sapiens, Mus musculus
R559KPVQIRPWNLN1Danio rerio
R589VGGVPRPLRAV3Homo sapiens, Danio rerio, Mus musculus
V8DYGFGVLVQSN2Homo sapiens, Mus musculus
V8-----------1Danio rerio
Y517FPPKGYAFLLF3Homo sapiens, Danio rerio, Mus musculus
Y543EDGKLYLCVSS3Homo sapiens, Danio rerio, Mus musculus

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