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mutLBSgeneDB |
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| Gene summary for CPEB4 |
 Gene summary |
| Basic gene Info. | Gene symbol | CPEB4 |
| Gene name | cytoplasmic polyadenylation element binding protein 4 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 5q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_030627.2, | |
| Description | CPE-BP4CPE-binding protein 4cytoplasmic polyadenylation element-binding protein 4hCPEB-4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610607 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000113742 | ||
| HPRD : 16746 | ||
| Vega : OTTHUMG00000130541 | ||
| Protein | UniProt: Q17RY0 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CPEB4 | |
| BioGPS: 80315 | ||
| Pathway | NCI Pathway Interaction Database: CPEB4 | |
| KEGG: CPEB4 | ||
| REACTOME: CPEB4 | ||
| Pathway Commons: CPEB4 | ||
| Context | iHOP: CPEB4 | |
| ligand binding site mutation search in PubMed: CPEB4 | ||
| UCL Cancer Institute: CPEB4 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CPEB4 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R559 | W561C | STAD | 1 | K473,F475 | V474L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CPEB4 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K473 | V474L | -0.70301238 | F475 | V474L | -0.70301238 | R559 | W561C | -0.49222884 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CPEB4 from PDB |
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| Differential gene expression and gene-gene network for CPEB4 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CPEB4 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CPEB4 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CPEB4 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of CPEB4 |
| Multiple alignments for Q17RY0 in multiple species |
| LBS | AA sequence | # species | Species | D553 | SPTIKDKPVQI | 3 | Homo sapiens, Danio rerio, Mus musculus | D613 | CYAGIDTDPEL | 3 | Homo sapiens, Danio rerio, Mus musculus | F475 | YSRKVFVGGLP | 3 | Homo sapiens, Danio rerio, Mus musculus | F519 | PKGYAFLLFQD | 3 | Homo sapiens, Danio rerio, Mus musculus | F583 | PRKTIFVGGVP | 3 | Homo sapiens, Danio rerio, Mus musculus | G478 | KVFVGGLPPDI | 3 | Homo sapiens, Danio rerio, Mus musculus | G623 | LKYPKGAGRVA | 3 | Homo sapiens, Danio rerio, Mus musculus | H504 | IVDWPHKAESK | 2 | Homo sapiens, Mus musculus | H504 | FVDWPHKAESK | 1 | Danio rerio | I551 | VSSPTIKDKPV | 3 | Homo sapiens, Danio rerio, Mus musculus | K473 | ERYSRKVFVGG | 3 | Homo sapiens, Danio rerio, Mus musculus | K541 | IEEDGKLYLCV | 2 | Homo sapiens, Mus musculus | K541 | MEEDGKLYLCV | 1 | Danio rerio | K554 | PTIKDKPVQIR | 3 | Homo sapiens, Danio rerio, Mus musculus | K622 | ELKYPKGAGRV | 3 | Homo sapiens, Danio rerio, Mus musculus | K658 | KRVEVKPYVLD | 3 | Homo sapiens, Danio rerio, Mus musculus | P481 | VGGLPPDIDED | 3 | Homo sapiens, Danio rerio, Mus musculus | P503 | LIVDWPHKAES | 2 | Homo sapiens, Mus musculus | P503 | LFVDWPHKAES | 1 | Danio rerio | P555 | TIKDKPVQIRP | 3 | Homo sapiens, Danio rerio, Mus musculus | P621 | PELKYPKGAGR | 3 | Homo sapiens, Danio rerio, Mus musculus | Q557 | KDKPVQIRPWN | 3 | Homo sapiens, Danio rerio, Mus musculus | R559 | KPVQIRPWNLS | 2 | Homo sapiens, Mus musculus | R559 | KPVQIRPWNLN | 1 | Danio rerio | R589 | VGGVPRPLRAV | 3 | Homo sapiens, Danio rerio, Mus musculus | V8 | DYGFGVLVQSN | 2 | Homo sapiens, Mus musculus | V8 | ----------- | 1 | Danio rerio | Y517 | FPPKGYAFLLF | 3 | Homo sapiens, Danio rerio, Mus musculus | Y543 | EDGKLYLCVSS | 3 | Homo sapiens, Danio rerio, Mus musculus |
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