mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CSRP3
Gene summary
Basic gene Info.Gene symbolCSRP3
Gene namecysteine and glycine-rich protein 3 (cardiac LIM protein)
CytomapUCSC genome browser: 11p15.1
Type of geneprotein-coding
DescriptionLIM domain only 4cardiac LIM domain proteincysteine and glycine-rich protein 3muscle lim protein isoform
Modification date20141219
dbXrefs MIM : 600824
Ensembl : ENSG00000129170
HPRD : 07525
Vega : OTTHUMG00000166100
ProteinUniProt: P50461
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CSRP3
BioGPS: 8048
PathwayNCI Pathway Interaction Database: CSRP3
Pathway Commons: CSRP3
ContextiHOP: CSRP3
ligand binding site mutation search in PubMed: CSRP3
UCL Cancer Institute: CSRP3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for CSRP3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CSRP3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CSRP3 from PDB

Differential gene expression and gene-gene network for CSRP3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CSRP3 and the right PPI network was created from samples without mutations in the LBS of CSRP3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CSRP3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0878544Cardiomyopathies9Biomarker, GeneticVariation
umls:C0236969Substance-Related Disorders1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CSRP3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CSRP3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)2o13AC120 C144

Conservation information for LBS of CSRP3
Multiple alignments for P50461 in multiple species
LBSAA sequence# speciesSpecies
C10GGGAKCGACEK3Homo sapiens, Bos taurus, Mus musculus
C10GGGAKCGACDK1Rattus norvegicus
C120GESEKCPRCGK4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
C123EKCPRCGKSVY4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
C13AKCGACEKTVY3Homo sapiens, Bos taurus, Mus musculus
C13AKCGACDKTVY1Rattus norvegicus
C144PWHKTCFRCAI3Homo sapiens, Bos taurus, Mus musculus
C144PWHKTCFPCAI1Rattus norvegicus
C147KTCFRCAICGK3Homo sapiens, Bos taurus, Mus musculus
C147KTCFPCAICGK1Rattus norvegicus
C150FRCAICGKSLE3Homo sapiens, Bos taurus, Mus musculus
C150FPCAICGKSLE1Rattus norvegicus
C171LYCKVCYAKNF4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
C34SFHKTCFHCMA4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
C37KTCFHCMACRK4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
C40FHCMACRKALD4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
C58ESEIYCKVCYG4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
C61IYCKVCYGRRY3Homo sapiens, Bos taurus, Mus musculus
C61IYCKVCYGRKY1Rattus norvegicus
H31NGRSFHKTCFH4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus

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