mutLBSgeneDB |
Gene summary for CSRP3 |
Gene summary |
Basic gene Info. | Gene symbol | CSRP3 |
Gene name | cysteine and glycine-rich protein 3 (cardiac LIM protein) | |
Synonyms | CLP|CMD1M|CMH12|CRP3|LMO4|MLP | |
Cytomap | UCSC genome browser: 11p15.1 | |
Type of gene | protein-coding | |
RefGenes | NM_003476.4, | |
Description | LIM domain only 4cardiac LIM domain proteincysteine and glycine-rich protein 3muscle lim protein isoform | |
Modification date | 20141219 | |
dbXrefs | MIM : 600824 | |
HGNC : HGNC | ||
Ensembl : ENSG00000129170 | ||
HPRD : 07525 | ||
Vega : OTTHUMG00000166100 | ||
Protein | UniProt: P50461 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CSRP3 | |
BioGPS: 8048 | ||
Pathway | NCI Pathway Interaction Database: CSRP3 | |
KEGG: CSRP3 | ||
REACTOME: CSRP3 | ||
Pathway Commons: CSRP3 | ||
Context | iHOP: CSRP3 | |
ligand binding site mutation search in PubMed: CSRP3 | ||
UCL Cancer Institute: CSRP3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CSRP3 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | C171 | V170D | BLCA | 1 | C10 | K9N | HNSC | 1 | C10 | A8E | KIRC | 1 | C144 | T143I | LUAD | 1 | C120 | E118D | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CSRP3 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C120 | E118D | -1.0609945 | C171 | V170D | -0.79802651 | C10 | A8E | -0.60094617 | C10 | K9N | -0.51575439 | C144 | T143I | -0.38464652 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CSRP3 from PDB |
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Differential gene expression and gene-gene network for CSRP3 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CSRP3 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0878544 | Cardiomyopathies | 9 | Biomarker, GeneticVariation |
umls:C0236969 | Substance-Related Disorders | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CSRP3 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CSRP3 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 2o10 | A | C10 | ZN | ZINC(2+) | 2o13 | A | C120 C144 | ZN | ZINC(2+) | 2o13 | A | C171 |
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Conservation information for LBS of CSRP3 |
Multiple alignments for P50461 in multiple species |
LBS | AA sequence | # species | Species | C10 | GGGAKCGACEK | 3 | Homo sapiens, Bos taurus, Mus musculus | C10 | GGGAKCGACDK | 1 | Rattus norvegicus | C120 | GESEKCPRCGK | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | C123 | EKCPRCGKSVY | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | C13 | AKCGACEKTVY | 3 | Homo sapiens, Bos taurus, Mus musculus | C13 | AKCGACDKTVY | 1 | Rattus norvegicus | C144 | PWHKTCFRCAI | 3 | Homo sapiens, Bos taurus, Mus musculus | C144 | PWHKTCFPCAI | 1 | Rattus norvegicus | C147 | KTCFRCAICGK | 3 | Homo sapiens, Bos taurus, Mus musculus | C147 | KTCFPCAICGK | 1 | Rattus norvegicus | C150 | FRCAICGKSLE | 3 | Homo sapiens, Bos taurus, Mus musculus | C150 | FPCAICGKSLE | 1 | Rattus norvegicus | C171 | LYCKVCYAKNF | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | C34 | SFHKTCFHCMA | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | C37 | KTCFHCMACRK | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | C40 | FHCMACRKALD | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | C58 | ESEIYCKVCYG | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | C61 | IYCKVCYGRRY | 3 | Homo sapiens, Bos taurus, Mus musculus | C61 | IYCKVCYGRKY | 1 | Rattus norvegicus | H31 | NGRSFHKTCFH | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus |
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