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mutLBSgeneDB |
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| Gene summary for CYB5B |
 Gene summary |
| Basic gene Info. | Gene symbol | CYB5B |
| Gene name | cytochrome b5 type B (outer mitochondrial membrane) | |
| Synonyms | CYB5-M|CYPB5M|OMB5 | |
| Cytomap | UCSC genome browser: 16q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_030579.2, | |
| Description | cytochrome b5 outer mitochondrial membrane isoformcytochrome b5 type Bouter mitochondrial membrane cytochrome b5type 2 cyt-b5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611964 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000103018 | ||
| HPRD : 13106 | ||
| Vega : OTTHUMG00000133020 | ||
| Protein | UniProt: O43169 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CYB5B | |
| BioGPS: 80777 | ||
| Pathway | NCI Pathway Interaction Database: CYB5B | |
| KEGG: CYB5B | ||
| REACTOME: CYB5B | ||
| Pathway Commons: CYB5B | ||
| Context | iHOP: CYB5B | |
| ligand binding site mutation search in PubMed: CYB5B | ||
| UCL Cancer Institute: CYB5B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CYB5B |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G57 | E58K | BLCA | 1 | L39 | L38F | HNSC | 1 | F51 | D51N | HNSC | 1 | M86 | D86E | KIRC | 1 | L87 | A87T | KIRC | 1 | L87 | A87V | KIRC | 1 | F51 | Y50C | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CYB5B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CYB5B from PDB |
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| Differential gene expression and gene-gene network for CYB5B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CYB5B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CYB5B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CYB5B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of CYB5B |
| Multiple alignments for O43169 in multiple species |
| LBS | AA sequence | # species | Species | A83 | GHSPDAREMLK | 2 | Mus musculus, Rattus norvegicus | A83 | GHSSDAREMLK | 1 | Homo sapiens | A83 | GHSEDAQELLE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A83 | GHSDEALRLLK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A83 | GHSSTAKAMLD | 1 | Arabidopsis thaliana | F51 | YDITRFLSEHP | 2 | Mus musculus, Rattus norvegicus | F51 | YDVTRFLNEHP | 1 | Homo sapiens | F51 | YDISKFLDAHP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F51 | YDVSQFKDEHP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F51 | YDVTKFLDDHP | 1 | Arabidopsis thaliana | F74 | DATESFEDVGH | 2 | Mus musculus, Rattus norvegicus | F74 | DASESFEDVGH | 1 | Homo sapiens | F74 | DASGPFEDVGH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F74 | DATESFVDIGH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F74 | DATDDFEDVGH | 1 | Arabidopsis thaliana | G57 | LSEHPGGEEVL | 2 | Mus musculus, Rattus norvegicus | G57 | LNEHPGGEEVL | 1 | Homo sapiens | G57 | LDAHPGGEEVL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G57 | KDEHPGGDEII | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G57 | LDDHPGGDEVI | 1 | Arabidopsis thaliana | H55 | RFLSEHPGGEE | 2 | Mus musculus, Rattus norvegicus | H55 | RFLNEHPGGEE | 1 | Homo sapiens | H55 | KFLDAHPGGEE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H55 | QFKDEHPGGDE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H55 | KFLDDHPGGDE | 1 | Arabidopsis thaliana | H79 | FEDVGHSPDAR | 2 | Mus musculus, Rattus norvegicus | H79 | FEDVGHSSDAR | 1 | Homo sapiens | H79 | FEDVGHSEDAQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H79 | FVDIGHSDEAL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H79 | FEDVGHSSTAK | 1 | Arabidopsis thaliana | I41 | ETWMVIHGRVY | 2 | Mus musculus, Rattus norvegicus | I41 | ELWLVIHGRVY | 1 | Homo sapiens | I41 | DLYIVVKDKVY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I41 | NFWIIIDDKVY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I41 | DCWIVIDGKVY | 1 | Arabidopsis thaliana | L39 | AEETWMVIHGR | 2 | Mus musculus, Rattus norvegicus | L39 | LKELWLVIHGR | 1 | Homo sapiens | L39 | RDDLYIVVKDK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L39 | PENFWIIIDDK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L39 | AKDCWIVIDGK | 1 | Arabidopsis thaliana | L62 | GGEEVLLEQAG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L62 | GGEEVLVDLAG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L62 | GGDEIIMDLGG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L62 | GGDEVILTSTG | 1 | Arabidopsis thaliana | L87 | DAREMLKQYYI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L87 | DAQELLEKFYI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L87 | EALRLLKGLYI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L87 | TAKAMLDEYYV | 1 | Arabidopsis thaliana | M86 | PDAREMLKQYY | 2 | Mus musculus, Rattus norvegicus | M86 | SDAREMLKQYY | 1 | Homo sapiens | M86 | EDAQELLEKFY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M86 | DEALRLLKGLY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M86 | STAKAMLDEYY | 1 | Arabidopsis thaliana | P56 | FLSEHPGGEEV | 2 | Mus musculus, Rattus norvegicus | P56 | FLNEHPGGEEV | 1 | Homo sapiens | P56 | FLDAHPGGEEV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P56 | FKDEHPGGDEI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P56 | FLDDHPGGDEV | 1 | Arabidopsis thaliana | Q65 | EVLLEQAGADA | 2 | Mus musculus, Rattus norvegicus | Q65 | EVLLEQAGVDA | 1 | Homo sapiens | Q65 | EVLVDLAGRDA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q65 | EIIMDLGGQDA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q65 | EVILTSTGKDA | 1 | Arabidopsis thaliana | S73 | ADATESFEDVG | 2 | Mus musculus, Rattus norvegicus | S73 | VDASESFEDVG | 1 | Homo sapiens | S73 | RDASGPFEDVG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S73 | QDATESFVDIG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S73 | KDATDDFEDVG | 1 | Arabidopsis thaliana | S80 | EDVGHSPDARE | 2 | Mus musculus, Rattus norvegicus | S80 | EDVGHSSDARE | 1 | Homo sapiens | S80 | EDVGHSEDAQE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S80 | VDIGHSDEALR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S80 | EDVGHSSTAKA | 1 | Arabidopsis thaliana | V48 | GRVYDITRFLS | 2 | Mus musculus, Rattus norvegicus | V48 | GRVYDVTRFLN | 1 | Homo sapiens | V48 | DKVYDISKFLD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V48 | DKVYDVSQFKD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V48 | GKVYDVTKFLD | 1 | Arabidopsis thaliana | V61 | PGGEEVLLEQA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V61 | PGGEEVLVDLA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V61 | PGGDEIIMDLG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V61 | PGGDEVILTST | 1 | Arabidopsis thaliana | V77 | ESFEDVGHSPD | 2 | Mus musculus, Rattus norvegicus | V77 | ESFEDVGHSSD | 1 | Homo sapiens | V77 | GPFEDVGHSED | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V77 | ESFVDIGHSDE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V77 | DDFEDVGHSST | 1 | Arabidopsis thaliana |
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