mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CYB5B
Gene summary
Basic gene Info.Gene symbolCYB5B
Gene namecytochrome b5 type B (outer mitochondrial membrane)
SynonymsCYB5-M|CYPB5M|OMB5
CytomapUCSC genome browser: 16q22.1
Type of geneprotein-coding
RefGenesNM_030579.2,
Descriptioncytochrome b5 outer mitochondrial membrane isoformcytochrome b5 type Bouter mitochondrial membrane cytochrome b5type 2 cyt-b5
Modification date20141207
dbXrefs MIM : 611964
HGNC : HGNC
Ensembl : ENSG00000103018
HPRD : 13106
Vega : OTTHUMG00000133020
ProteinUniProt: O43169
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CYB5B
BioGPS: 80777
PathwayNCI Pathway Interaction Database: CYB5B
KEGG: CYB5B
REACTOME: CYB5B
Pathway Commons: CYB5B
ContextiHOP: CYB5B
ligand binding site mutation search in PubMed: CYB5B
UCL Cancer Institute: CYB5B
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CYB5B
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
G57E58KBLCA1
L39L38FHNSC1
F51D51NHNSC1
M86D86EKIRC1
L87A87TKIRC1
L87A87VKIRC1
F51Y50CLUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CYB5B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CYB5B from PDB

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Differential gene expression and gene-gene network for CYB5B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CYB5B and the right PPI network was created from samples without mutations in the LBS of CYB5B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CYB5B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CYB5B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CYB5B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of CYB5B
Multiple alignments for O43169 in multiple species
LBSAA sequence# speciesSpecies
A83GHSPDAREMLK2Mus musculus, Rattus norvegicus
A83GHSSDAREMLK1Homo sapiens
A83GHSEDAQELLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A83GHSDEALRLLK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A83GHSSTAKAMLD1Arabidopsis thaliana
F51YDITRFLSEHP2Mus musculus, Rattus norvegicus
F51YDVTRFLNEHP1Homo sapiens
F51YDISKFLDAHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F51YDVSQFKDEHP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F51YDVTKFLDDHP1Arabidopsis thaliana
F74DATESFEDVGH2Mus musculus, Rattus norvegicus
F74DASESFEDVGH1Homo sapiens
F74DASGPFEDVGH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F74DATESFVDIGH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F74DATDDFEDVGH1Arabidopsis thaliana
G57LSEHPGGEEVL2Mus musculus, Rattus norvegicus
G57LNEHPGGEEVL1Homo sapiens
G57LDAHPGGEEVL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G57KDEHPGGDEII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G57LDDHPGGDEVI1Arabidopsis thaliana
H55RFLSEHPGGEE2Mus musculus, Rattus norvegicus
H55RFLNEHPGGEE1Homo sapiens
H55KFLDAHPGGEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H55QFKDEHPGGDE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H55KFLDDHPGGDE1Arabidopsis thaliana
H79FEDVGHSPDAR2Mus musculus, Rattus norvegicus
H79FEDVGHSSDAR1Homo sapiens
H79FEDVGHSEDAQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H79FVDIGHSDEAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H79FEDVGHSSTAK1Arabidopsis thaliana
I41ETWMVIHGRVY2Mus musculus, Rattus norvegicus
I41ELWLVIHGRVY1Homo sapiens
I41DLYIVVKDKVY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I41NFWIIIDDKVY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I41DCWIVIDGKVY1Arabidopsis thaliana
L39AEETWMVIHGR2Mus musculus, Rattus norvegicus
L39LKELWLVIHGR1Homo sapiens
L39RDDLYIVVKDK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L39PENFWIIIDDK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L39AKDCWIVIDGK1Arabidopsis thaliana
L62GGEEVLLEQAG3Homo sapiens, Mus musculus, Rattus norvegicus
L62GGEEVLVDLAG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L62GGDEIIMDLGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L62GGDEVILTSTG1Arabidopsis thaliana
L87DAREMLKQYYI3Homo sapiens, Mus musculus, Rattus norvegicus
L87DAQELLEKFYI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L87EALRLLKGLYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L87TAKAMLDEYYV1Arabidopsis thaliana
M86PDAREMLKQYY2Mus musculus, Rattus norvegicus
M86SDAREMLKQYY1Homo sapiens
M86EDAQELLEKFY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M86DEALRLLKGLY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M86STAKAMLDEYY1Arabidopsis thaliana
P56FLSEHPGGEEV2Mus musculus, Rattus norvegicus
P56FLNEHPGGEEV1Homo sapiens
P56FLDAHPGGEEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P56FKDEHPGGDEI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P56FLDDHPGGDEV1Arabidopsis thaliana
Q65EVLLEQAGADA2Mus musculus, Rattus norvegicus
Q65EVLLEQAGVDA1Homo sapiens
Q65EVLVDLAGRDA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q65EIIMDLGGQDA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q65EVILTSTGKDA1Arabidopsis thaliana
S73ADATESFEDVG2Mus musculus, Rattus norvegicus
S73VDASESFEDVG1Homo sapiens
S73RDASGPFEDVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S73QDATESFVDIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S73KDATDDFEDVG1Arabidopsis thaliana
S80EDVGHSPDARE2Mus musculus, Rattus norvegicus
S80EDVGHSSDARE1Homo sapiens
S80EDVGHSEDAQE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S80VDIGHSDEALR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S80EDVGHSSTAKA1Arabidopsis thaliana
V48GRVYDITRFLS2Mus musculus, Rattus norvegicus
V48GRVYDVTRFLN1Homo sapiens
V48DKVYDISKFLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V48DKVYDVSQFKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V48GKVYDVTKFLD1Arabidopsis thaliana
V61PGGEEVLLEQA3Homo sapiens, Mus musculus, Rattus norvegicus
V61PGGEEVLVDLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V61PGGDEIIMDLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V61PGGDEVILTST1Arabidopsis thaliana
V77ESFEDVGHSPD2Mus musculus, Rattus norvegicus
V77ESFEDVGHSSD1Homo sapiens
V77GPFEDVGHSED1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V77ESFVDIGHSDE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V77DDFEDVGHSST1Arabidopsis thaliana


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