mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ZFP91
Gene summary
Basic gene Info.Gene symbolZFP91
Gene nameZFP91 zinc finger protein
SynonymsDMS-8|DSM-8|PZF|ZFP-91|ZNF757
CytomapUCSC genome browser: 11q12
Type of geneprotein-coding
RefGenesNM_001197051.1,
NM_053023.4,
DescriptionE3 ubiquitin-protein ligase ZFP91drug resistance-associated sequence in melanoma 8penta zinc finger proteinzinc finger protein 757zinc finger protein 91 homologzinc finger protein homologous to Zfp91 in mouse
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000186660
HPRD : 11700
Vega : OTTHUMG00000137391
ProteinUniProt: Q96JP5
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ZFP91
BioGPS: 80829
PathwayNCI Pathway Interaction Database: ZFP91
KEGG: ZFP91
REACTOME: ZFP91
Pathway Commons: ZFP91
ContextiHOP: ZFP91
ligand binding site mutation search in PubMed: ZFP91
UCL Cancer Institute: ZFP91
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0007250activation of NF-kappaB-inducing kinase activity20682767
GO:0070534protein K63-linked ubiquitination20682767


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Ligand binding site mutations for ZFP91
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H394T395NBLCA1
H390R391QHNSC1
C377R379GLUSC1
C377A378DUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ZFP91
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C377R379G-1.2272256
H390R391Q-0.75310605
C377A378D-0.69868996
H394T395N-0.37094512
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZFP91 from PDB

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Differential gene expression and gene-gene network for ZFP91
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ZFP91 and the right PPI network was created from samples without mutations in the LBS of ZFP91. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ZFP91
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ZFP91
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ZFP91 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of ZFP91
Multiple alignments for Q96JP5 in multiple species
LBSAA sequence# speciesSpecies


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