mutLBSgeneDB |
Gene summary for KMT2D |
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Basic gene Info. | Gene symbol | KMT2D |
Gene name | lysine (K)-specific methyltransferase 2D | |
Synonyms | AAD10|ALR|CAGL114|KABUK1|KMS|MLL2|MLL4|TNRC21 | |
Cytomap | UCSC genome browser: 12q13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_003482.3, | |
Description | ALL1-related proteinKabuki make-up syndromeKabuki mental retardation syndromehistone-lysine N-methyltransferase 2Dhistone-lysine N-methyltransferase MLL2lysine N-methyltransferase 2Dmyeloid/lymphoid or mixed-lineage leukemia 2trinucleotide repeat c | |
Modification date | 20141219 | |
dbXrefs | MIM : 602113 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167548 | ||
HPRD : 03664 | ||
Vega : OTTHUMG00000166524 | ||
Protein | UniProt: O14686 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KMT2D | |
BioGPS: 8085 | ||
Pathway | NCI Pathway Interaction Database: KMT2D | |
KEGG: KMT2D | ||
REACTOME: KMT2D | ||
Pathway Commons: KMT2D | ||
Context | iHOP: KMT2D | |
ligand binding site mutation search in PubMed: KMT2D | ||
UCL Cancer Institute: KMT2D | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0043627 | response to estrogen | 16603732 |
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Ligand binding site mutations for KMT2D |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | C5525 | C5525S | COAD | 1 | C5477 | C5477G | STAD | 1 | Y5512 | D5511A | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for KMT2D |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C5525 | C5525S | -1.404374 | Y5512 | D5511A | -1.3919313 | C5477 | C5477G | -1.0716764 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for KMT2D |
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Phenotype information for KMT2D |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0796004 | Kabuki syndrome | 22 | Biomarker, GeneticVariation |
umls:C0079744 | Lymphoma, Large B-Cell, Diffuse | 2 | Biomarker |
umls:C0024301 | Lymphoma, Follicular | 2 | Biomarker |
umls:C0279626 | Esophageal Squamous Cell Carcinoma | 1 | Biomarker |
umls:C0021364 | Infertility, Male | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for KMT2D |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4z4p | A | C5477 C5525 | SAH | S-ADENOSYL-L-HOMOCYSTEINE | 4z4p | A | Y5512 C5525 |
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Conservation information for LBS of KMT2D |
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LBS | AA sequence | # species | Species |
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