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mutLBSgeneDB |
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| Gene summary for CALML3 |
 Gene summary |
| Basic gene Info. | Gene symbol | CALML3 |
| Gene name | calmodulin-like 3 | |
| Synonyms | CLP | |
| Cytomap | UCSC genome browser: 10p15.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005185.3, | |
| Description | caM-like proteincalmodulin-like protein 3calmodulin-related protein NB-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 114184 | |
| HGNC : HGNC | ||
| HPRD : 00244 | ||
| Protein | UniProt: P27482 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CALML3 | |
| BioGPS: 810 | ||
| Pathway | NCI Pathway Interaction Database: CALML3 | |
| KEGG: CALML3 | ||
| REACTOME: CALML3 | ||
| Pathway Commons: CALML3 | ||
| Context | iHOP: CALML3 | |
| ligand binding site mutation search in PubMed: CALML3 | ||
| UCL Cancer Institute: CALML3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CALML3 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D132,D134 | G133E | SKCM | 2 | D96 | D96E | LUAD | 1 | D59,D57 | R58Q | SKCM | 1 | D130 | D130N | SKCM | 1 | E105 | R107Q | SKCM | 1 | C27,D25 | G26S | STAD | 1 | D130 | D130N | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CALML3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D57 | R58Q | -1.7451667 | D59 | R58Q | -1.7451667 | E105 | R107Q | -0.9765237 | D132 | G133E | -0.80815191 | D134 | G133E | -0.80815191 | C27 | G26S | -0.5656185 | D25 | G26S | -0.5656185 | D96 | D96E | -0.41934796 | D130 | D130N | -0.33248459 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CALML3 from PDB |
| PDB ID | PDB title | PDB structure | 1GGZ | CRYSTAL STRUCTURE OF THE CALMODULIN-LIKE PROTEIN (HCLP) FROM HUMAN EPITHELIAL CELLS |  |
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| Differential gene expression and gene-gene network for CALML3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CALML3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CALML3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CALML3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of CALML3 |
| Multiple alignments for P27482 in multiple species |
| LBS | AA sequence | # species | Species | C27 | KDGDGCITTKE | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | C27 | KDGDGCITTRE | 1 | Homo sapiens | C27 | KDGDGSITTQE | 1 | Mus musculus | C27 | KDGDGCITTQE | 1 | Rattus norvegicus | C27 | RDGDGCITTME | 1 | Gallus gallus | D130 | MIREADVDGDG | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | D130 | MIQAADTDGDG | 2 | Mus musculus, Rattus norvegicus | D130 | MIRAADTDGDG | 1 | Homo sapiens | D130 | MIKEADCNNDG | 1 | Gallus gallus | D132 | READVDGDGQI | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | D132 | QAADTDGDGQV | 2 | Mus musculus, Rattus norvegicus | D132 | RAADTDGDGQV | 1 | Homo sapiens | D132 | KEADCNNDGQV | 1 | Gallus gallus | D134 | ADTDGDGQVNY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D134 | ADVDGDGQINY | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | D134 | ADCNNDGQVNY | 1 | Gallus gallus | D21 | AFSLFDKDGDG | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | D21 | AFSLFDRDGDG | 1 | Gallus gallus | D23 | SLFDKDGDGCI | 5 | Homo sapiens, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | D23 | SLFDKDGDGSI | 1 | Mus musculus | D23 | SLFDRDGDGCI | 1 | Gallus gallus | D25 | FDKDGDGCITT | 5 | Homo sapiens, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | D25 | FDKDGDGSITT | 1 | Mus musculus | D25 | FDRDGDGCITT | 1 | Gallus gallus | D57 | MINEVDADGNG | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | D57 | MVNEIDKDGNG | 2 | Mus musculus, Rattus norvegicus | D57 | MMSEIDRDGNG | 1 | Homo sapiens | D57 | MVGEVDADGSG | 1 | Gallus gallus | D59 | NEVDADGNGTI | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | D59 | NEIDKDGNGTV | 2 | Mus musculus, Rattus norvegicus | D59 | SEIDRDGNGTV | 1 | Homo sapiens | D59 | GEVDADGSGTI | 1 | Gallus gallus | D94 | AFRVFDKDGNG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus | D94 | AFRVFDKDQNG | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | D96 | RVFDKDGNGFV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D96 | RVFDKDQNGFI | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | D96 | RVFDKDGNGYI | 1 | Gallus gallus | E105 | FVSAAELRHVM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E105 | FISAAELRHVM | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | E105 | YISAAELRHVM | 1 | Gallus gallus | E141 | QVNYEEFVHML | 2 | Mus musculus, Rattus norvegicus | E141 | QINYEEFVKIM | 2 | Arabidopsis thaliana, Arabidopsis thaliana | E141 | QVNYEEFVRVL | 1 | Homo sapiens | E141 | QVNYEEFVRMM | 1 | Gallus gallus | E141 | QINYEEFVKVM | 1 | Oryza sativa subsp. japonica | E32 | CITTKELGTVM | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | E32 | CITTRELGTVM | 1 | Homo sapiens | E32 | SITTQELGTVM | 1 | Mus musculus | E32 | CITTQELGTVM | 1 | Rattus norvegicus | E32 | CITTMELGTVM | 1 | Gallus gallus | E68 | TIDFPEFLNLM | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | E68 | TVDFPEFLTMM | 2 | Mus musculus, Rattus norvegicus | E68 | TVDFPEFLGMM | 1 | Homo sapiens | E68 | TIDFPEFLSLM | 1 | Gallus gallus | F100 | KDGNGFVSAAE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F100 | KDQNGFISAAE | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | F100 | KDGNGYISAAE | 1 | Gallus gallus | N61 | VDADGNGTIDF | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | N61 | IDKDGNGTVDF | 2 | Mus musculus, Rattus norvegicus | N61 | IDRDGNGTVDF | 1 | Homo sapiens | N61 | VDADGSGTIDF | 1 | Gallus gallus | N98 | FDKDGNGFVSA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N98 | FDKDQNGFISA | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | N98 | FDKDGNGYISA | 1 | Gallus gallus | Q136 | TDGDGQVNYEE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q136 | VDGDGQINYEE | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | Q136 | CNNDGQVNYEE | 1 | Gallus gallus | T63 | ADGNGTIDFPE | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica | T63 | KDGNGTVDFPE | 2 | Mus musculus, Rattus norvegicus | T63 | RDGNGTVDFPE | 1 | Homo sapiens | T63 | ADGSGTIDFPE | 1 | Gallus gallus |
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