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mutLBSgeneDB |
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| Gene summary for CAMK4 |
 Gene summary |
| Basic gene Info. | Gene symbol | CAMK4 |
| Gene name | calcium/calmodulin-dependent protein kinase IV | |
| Synonyms | CaMK IV|CaMK-GR|IV|caMK | |
| Cytomap | UCSC genome browser: 5q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001744.4, | |
| Description | CAM kinase IVCAM kinase- GRbrain Ca(2+)-calmodulin-dependent protein kinase type IVbrain Ca++-calmodulin-dependent protein kinase type IVcaM kinase-GRcalcium/calmodulin-dependent protein kinase type IVcalcium/calmodulin-dependent protein kinase type | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 114080 | |
| HGNC : HGNC | ||
| HPRD : 07169 | ||
| Protein | UniProt: Q16566 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CAMK4 | |
| BioGPS: 814 | ||
| Pathway | NCI Pathway Interaction Database: CAMK4 | |
| KEGG: CAMK4 | ||
| REACTOME: CAMK4 | ||
| Pathway Commons: CAMK4 | ||
| Context | iHOP: CAMK4 | |
| ligand binding site mutation search in PubMed: CAMK4 | ||
| UCL Cancer Institute: CAMK4 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0045893 | positive regulation of transcription, DNA-templated | 8855261 |
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| Ligand binding site mutations for CAMK4 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E119 | E119Q | KIRC | 1 | L171 | L170F | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CAMK4 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E119 | E119Q | -1.2627728 | L171 | L170F | -0.61660543 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CAMK4 from PDB |
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| Differential gene expression and gene-gene network for CAMK4 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CAMK4 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0236736 | Cocaine-Related Disorders | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CAMK4 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB07664 | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | Small molecule |  |
| Experimental | DB07676 | 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CAMK4 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | DKI | CDK1/2 INHIBITOR III | 2w4o | A | E119 L171 |
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| Conservation information for LBS of CAMK4 |
| Multiple alignments for Q16566 in multiple species |
| LBS | AA sequence | # species | Species |
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