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mutLBSgeneDB |
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| Gene summary for RNF146 |
 Gene summary |
| Basic gene Info. | Gene symbol | RNF146 |
| Gene name | ring finger protein 146 | |
| Synonyms | dJ351K20.1 | |
| Cytomap | UCSC genome browser: 6q22.1-q22.33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001242847.1, NM_001242848.1,NM_001242844.1,NM_001242845.1,NM_001242846.1, NM_001242849.1,NM_001242850.1,NM_001242851.1,NM_001242852.1, NM_030963.3,NR_045102.1,NR_045103.1, | |
| Description | 2610509H23RikE3 ubiquitin-protein ligase RNF146dactylidiniduna | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612137 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000118518 | ||
| Vega : OTTHUMG00000015522 | ||
| Protein | UniProt: Q9NTX7 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RNF146 | |
| BioGPS: 81847 | ||
| Pathway | NCI Pathway Interaction Database: RNF146 | |
| KEGG: RNF146 | ||
| REACTOME: RNF146 | ||
| Pathway Commons: RNF146 | ||
| Context | iHOP: RNF146 | |
| ligand binding site mutation search in PubMed: RNF146 | ||
| UCL Cancer Institute: RNF146 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0051865 | protein autoubiquitination | 21478859 |
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| Ligand binding site mutations for RNF146 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I140 | L139F | BRCA | 1 | Y108 | W106R | COAD | 1 | C74 | R75Q | HNSC | 1 | R162 | R162H | STAD | 1 | R164,R162 | R163H | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RNF146 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y108 | W106R | -1.1405634 | I140 | L139F | -1.1111068 | R162 | R163H | -1.0670326 | R164 | R163H | -1.0670326 | R162 | R162H | -1.0042405 | C74 | R75Q | -0.99178763 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RNF146 from PDB |
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| Differential gene expression and gene-gene network for RNF146 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RNF146 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RNF146 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RNF146 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of RNF146 |
| Multiple alignments for Q9NTX7 in multiple species |
| LBS | AA sequence | # species | Species | C37 | LTVPECAICLQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C37 | LPVPECPICLQ | 1 | Danio rerio | C37 | LSVPECAICLQ | 1 | Xenopus tropicalis | C40 | PECAICLQTCV | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | C40 | PECPICLQSCV | 1 | Danio rerio | C52 | PVSLPCKHVFC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C52 | PVRLPCRHIFC | 1 | Danio rerio | C52 | PVSLPCKHIFC | 1 | Xenopus tropicalis | C57 | CKHVFCYLCVK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C57 | CRHIFCFLCVK | 1 | Danio rerio | C57 | CKHIFCYLCVK | 1 | Xenopus tropicalis | C60 | VFCYLCVKGAS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C60 | IFCFLCVKGAS | 1 | Danio rerio | C60 | IFCYLCVKGAS | 1 | Xenopus tropicalis | C71 | WLGKRCALCRQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C71 | WHSKRCALCRR | 1 | Danio rerio | C71 | WLGRRCALCRQ | 1 | Xenopus tropicalis | C74 | KRCALCRQEIP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C74 | KRCALCRREVP | 1 | Danio rerio | C74 | RRCALCRQEIP | 1 | Xenopus tropicalis | G110 | AWYYEGRNGWW | 5 | Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus | G110 | VWYYEGRNGWW | 1 | Rattus norvegicus | G180 | KKGVAGLRLDC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G180 | KKGVAGLRLDP | 1 | Danio rerio | G180 | KKGVAGLRLEC | 1 | Xenopus tropicalis | H54 | SLPCKHVFCYL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H54 | RLPCRHIFCFL | 1 | Danio rerio | H54 | SLPCKHIFCYL | 1 | Xenopus tropicalis | I140 | NTEMLIAGFLY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I140 | STEMLIAGFLY | 2 | Xenopus tropicalis, Bos taurus | I140 | SAEMLIAGFLY | 1 | Danio rerio | K176 | IDIPKKGVAGL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K176 | VDIPKKGVAGL | 2 | Danio rerio, Xenopus tropicalis | Q154 | LENMVQYRRNE | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | R111 | WYYEGRNGWWQ | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | R162 | RNEHGRRRKIK | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | R162 | RNEHGRRRRMK | 1 | Danio rerio | R164 | EHGRRRKIKRD | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | R164 | EHGRRRRMKRD | 1 | Danio rerio | W115 | GRNGWWQYDER | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | Y108 | EYAWYYEGRNG | 4 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus | Y108 | GHAWYYEGRNG | 1 | Danio rerio | Y108 | EYVWYYEGRNG | 1 | Rattus norvegicus | Y117 | NGWWQYDERTS | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | Y145 | IAGFLYVADLE | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus |
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