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mutLBSgeneDB |
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| Gene summary for RAB1B |
 Gene summary |
| Basic gene Info. | Gene symbol | RAB1B |
| Gene name | RAB1B, member RAS oncogene family | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 11q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_030981.2, | |
| Description | ras-related protein Rab-1Bsmall GTP-binding protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612565 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000174903 | ||
| HPRD : 11469 | ||
| Vega : OTTHUMG00000166916 | ||
| Protein | UniProt: Q9H0U4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RAB1B | |
| BioGPS: 81876 | ||
| Pathway | NCI Pathway Interaction Database: RAB1B | |
| KEGG: RAB1B | ||
| REACTOME: RAB1B | ||
| Pathway Commons: RAB1B | ||
| Context | iHOP: RAB1B | |
| ligand binding site mutation search in PubMed: RAB1B | ||
| UCL Cancer Institute: RAB1B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for RAB1B |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E35 | E35K | BRCA | 1 | E35 | E35Q | HNSC | 1 | A152 | A152T | OV | 1 | S151 | T150M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RAB1B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E35 | E35Q | -0.99677188 | E35 | E35K | -0.94692145 | A152 | A152T | -0.81802332 | S151 | T150M | -0.67795169 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RAB1B from PDB |
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| Differential gene expression and gene-gene network for RAB1B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RAB1B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RAB1B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RAB1B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GDP | GUANOSINE-5'-DIPHOSPHATE | 4hlq | B | E35 A152 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4hlq | H | E35 A152 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 3nkv | A | E35 S151 A152 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 3nkv | B | E35 S151 A152 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4hlq | D | E35 S151 A152 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4hlq | F | E35 S151 A152 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4hlq | J | E35 S151 A152 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4i1o | A | S151 A152 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4i1o | C | S151 A152 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4i1o | E | S151 A152 | GDP | GUANOSINE-5'-DIPHOSPHATE | 4i1o | G | S151 A152 |
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| Conservation information for LBS of RAB1B |
| Multiple alignments for Q9H0U4 in multiple species |
| LBS | AA sequence | # species | Species | A152 | FLETSAKNATN | 3 | Homo sapiens, Mus musculus, Bos taurus | A65 | QIWDTAGQERF | 3 | Homo sapiens, Mus musculus, Bos taurus | C23 | GVGKSCLLLRF | 3 | Homo sapiens, Mus musculus, Bos taurus | D124 | VGNKSDLTTKK | 3 | Homo sapiens, Mus musculus, Bos taurus | E35 | DDTYTESYIST | 3 | Homo sapiens, Mus musculus, Bos taurus | F45 | TIGVDFKIRTI | 3 | Homo sapiens, Mus musculus, Bos taurus | G18 | LIGDSGVGKSC | 3 | Homo sapiens, Mus musculus, Bos taurus | G20 | GDSGVGKSCLL | 3 | Homo sapiens, Mus musculus, Bos taurus | G66 | IWDTAGQERFR | 3 | Homo sapiens, Mus musculus, Bos taurus | I38 | YTESYISTIGV | 3 | Homo sapiens, Mus musculus, Bos taurus | K122 | LLVGNKSDLTT | 3 | Homo sapiens, Mus musculus, Bos taurus | K153 | LETSAKNATNV | 3 | Homo sapiens, Mus musculus, Bos taurus | K21 | DSGVGKSCLLL | 3 | Homo sapiens, Mus musculus, Bos taurus | L125 | GNKSDLTTKKV | 3 | Homo sapiens, Mus musculus, Bos taurus | N121 | KLLVGNKSDLT | 3 | Homo sapiens, Mus musculus, Bos taurus | Q60 | KTIKLQIWDTA | 3 | Homo sapiens, Mus musculus, Bos taurus | S151 | PFLETSAKNAT | 3 | Homo sapiens, Mus musculus, Bos taurus | S17 | LLIGDSGVGKS | 3 | Homo sapiens, Mus musculus, Bos taurus | S22 | SGVGKSCLLLR | 3 | Homo sapiens, Mus musculus, Bos taurus | S36 | DTYTESYISTI | 3 | Homo sapiens, Mus musculus, Bos taurus | S39 | TESYISTIGVD | 3 | Homo sapiens, Mus musculus, Bos taurus | T34 | ADDTYTESYIS | 3 | Homo sapiens, Mus musculus, Bos taurus | T40 | ESYISTIGVDF | 3 | Homo sapiens, Mus musculus, Bos taurus | T64 | LQIWDTAGQER | 3 | Homo sapiens, Mus musculus, Bos taurus | V19 | IGDSGVGKSCL | 3 | Homo sapiens, Mus musculus, Bos taurus | V43 | ISTIGVDFKIR | 3 | Homo sapiens, Mus musculus, Bos taurus | W62 | IKLQIWDTAGQ | 3 | Homo sapiens, Mus musculus, Bos taurus | Y33 | FADDTYTESYI | 3 | Homo sapiens, Mus musculus, Bos taurus | Y37 | TYTESYISTIG | 3 | Homo sapiens, Mus musculus, Bos taurus | Y77 | TITSSYYRGAH | 3 | Homo sapiens, Mus musculus, Bos taurus |
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