mutLBSgeneDB |
Gene summary for SYN3 |
![]() |
Basic gene Info. | Gene symbol | SYN3 |
Gene name | synapsin III | |
Synonyms | - | |
Cytomap | UCSC genome browser: 22q12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001135774.1, NM_003490.3,NM_133633.2,NM_133632.1, | |
Description | cN28H9.2 (synapsin III)synapsin-3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602705 | |
HGNC : HGNC | ||
Ensembl : ENSG00000185666 | ||
HPRD : 04083 | ||
Vega : OTTHUMG00000031004 | ||
Protein | UniProt: O14994 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SYN3 | |
BioGPS: 8224 | ||
Pathway | NCI Pathway Interaction Database: SYN3 | |
KEGG: SYN3 | ||
REACTOME: SYN3 | ||
Pathway Commons: SYN3 | ||
Context | iHOP: SYN3 | |
ligand binding site mutation search in PubMed: SYN3 | ||
UCL Cancer Institute: SYN3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for SYN3 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
![]() |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | W314 | G312V | KIRC | 1 | N317 | T318A | LUAD | 1 | E365 | E365Q | LUSC | 1 | E284 | E284K | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for SYN3 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | E365 | E365Q | -1.341758 | E284 | E284K | -0.80911117 | W314 | G312V | -0.26936782 | N317 | T318A | -0.1506334 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for SYN3 |
![]() |
![]() |
Top |
Top |
Phenotype information for SYN3 |
![]() |
Disease ID | Disease name | # PubMed | Association type |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for SYN3 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ANP | AMP-PNP | 2p0a | A | E284 W314 N317 E365 | ANP | AMP-PNP | 2p0a | B | E284 W314 N317 E365 |
Top |
Conservation information for LBS of SYN3 |
![]() |
LBS | AA sequence | # species | Species | A252 | IKLGHAHAGMG | 2 | Mus musculus, Rattus norvegicus | A252 | VKLGHAHAGMG | 1 | Homo sapiens | A254 | LGHAHAGMGKI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A285 | YATTEAFIDSK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A316 | SGNWKANTGSA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D292 | IDSKYDIRIQK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E284 | TYATTEAFIDS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E365 | RDYIIEVMDSS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G255 | GHAHAGMGKIK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H253 | KLGHAHAGMGK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I287 | TTEAFIDSKYD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I364 | GRDYIIEVMDS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K204 | YNFCSKPWVFS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K248 | FPVVIKLGHAH | 2 | Mus musculus, Rattus norvegicus | K248 | FPVVVKLGHAH | 1 | Homo sapiens | K258 | HAGMGKIKVEN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K315 | ISGNWKANTGS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K352 | DICAVKAVHSK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N317 | GNWKANTGSAM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V246 | PNFPVVIKLGH | 2 | Mus musculus, Rattus norvegicus | V246 | PHFPVVVKLGH | 1 | Homo sapiens | W314 | SISGNWKANTG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |