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mutLBSgeneDB |
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| Gene summary for CDC7 |
 Gene summary |
| Basic gene Info. | Gene symbol | CDC7 |
| Gene name | cell division cycle 7 | |
| Synonyms | CDC7L1|HsCDC7|Hsk1|huCDC7 | |
| Cytomap | UCSC genome browser: 1p22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001134419.1, NM_001134420.1,NM_003503.3, | |
| Description | CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1CDC7-related kinasecell division cycle 7 homologcell division cycle 7-like protein 1cell division cycle 7-related protein kinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603311 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000097046 | ||
| HPRD : 10345 | ||
| Vega : OTTHUMG00000047810 | ||
| Protein | UniProt: O00311 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CDC7 | |
| BioGPS: 8317 | ||
| Pathway | NCI Pathway Interaction Database: CDC7 | |
| KEGG: CDC7 | ||
| REACTOME: CDC7 | ||
| Pathway Commons: CDC7 | ||
| Context | iHOP: CDC7 | |
| ligand binding site mutation search in PubMed: CDC7 | ||
| UCL Cancer Institute: CDC7 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CDC7 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I64 | D62Y | COAD | 1 | M118 | G119V | COAD | 1 | I64 | D62G | COAD | 1 | M118 | G119R | COAD | 1 | M118 | G119E | COAD | 1 | I64 | D62G | OV | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CDC7 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | I64 | D62G | -1.4648895 | I64 | D62Y | -0.99244513 | M118 | G119E | -0.5636249 | M118 | G119V | -0.55246825 | M118 | G119R | -0.53235668 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CDC7 from PDB |
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| Differential gene expression and gene-gene network for CDC7 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CDC7 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CDC7 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CDC7 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ADP | ADP | 4f99 | A | I64 M118 | ADP | ADP | 4f9a | C | I64 M118 | ADP | ADP | 4f9a | A | M118 | 0SY | 2-(PYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2- C]PYRIDIN-4-ONE | 4f9b | C | M118 | 0SX | 8-CHLORO-2-[(2S)-PYRROLIDIN-2-YL][1]BENZOFURO[3,2- D]PYRIMIDIN-4(3H)-ONE | 4f9c | A | M118 |
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| Conservation information for LBS of CDC7 |
| Multiple alignments for O00311 in multiple species |
| LBS | AA sequence | # species | Species |
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