mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for CASP3

Gene summary

Basic gene Info.	Gene symbol	CASP3
	Gene name	caspase 3, apoptosis-related cysteine peptidase
	Synonyms	CPP32\|CPP32B\|SCA-1
	Cytomap	UCSC genome browser: 4q34
	Type of gene	protein-coding
	RefGenes	NM_004346.3, NM_032991.2,
	Description	CASP-3CPP-32PARP cleavage proteaseSREBP cleavage activity 1apopaincaspase 3, apoptosis-related cysteine proteasecaspase-3cysteine protease CPP32procaspase3protein Yama
	Modification date	20141222
dbXrefs	MIM : 600636
	HGNC : HGNC
	Ensembl : ENSG00000164305
	HPRD : 02799
	Vega : OTTHUMG00000133681
Protein	UniProt: P42574 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CASP3
	BioGPS: 836
Pathway	NCI Pathway Interaction Database: CASP3
	KEGG: CASP3
	REACTOME: CASP3
	Pathway Commons: CASP3
Context	iHOP: CASP3
	ligand binding site mutation search in PubMed: CASP3
	UCL Cancer Institute: CASP3
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0006508	proteolysis	12888622
GO:0030218	erythrocyte differentiation	17167422
GO:0097194	execution phase of apoptosis	8689682

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Ligand binding site mutations for CASP3

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
K53	K53N	COAD	1
N89	D90Y	COAD	1
N141	F143S	COAD	1
R111	R111K	HNSC	1
R64	R64L	LUAD	1
Q161	Q161L	LUAD	1
K137	L136M	SKCM	1
G165,C163	R164L	STAD	1
F193	D192N	UCEC	1
S120	L118I	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for CASP3

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
N141	F143S	-1.8425658
K137	L136M	-1.6474109
R111	R111K	-1.0761659
K53	K53N	-0.95271108
N89	D90Y	-0.71786742
F193	D192N	-0.70760757
S120	L118I	-0.52581089
R64	R64L	-0.46416757
Q161	Q161L	-0.38512
G165	R164L	-0.26012685
C163	R164L	-0.26012685

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CASP3 from PDB

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Differential gene expression and gene-gene network for CASP3

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of CASP3 and the right PPI network was created from samples without mutations in the LBS of CASP3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for CASP3

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0002395	Alzheimer Disease	10	AlteredExpression, Biomarker
umls:C0007786	Brain Ischemia	3	AlteredExpression, Biomarker
umls:C0011882	Diabetic Neuropathies	2	Biomarker
umls:C0027055	Myocardial Reperfusion Injury	2	Biomarker
umls:C0037929	Spinal Cord Injuries	2	Biomarker
umls:C0038220	Status Epilepticus	2	Biomarker
umls:C0026936	Mycoplasma Infections	1	Biomarker
umls:C0006663	Calcinosis	1	Biomarker
umls:C2937358	Cerebral Hemorrhage	1	Biomarker
umls:C0011860	Diabetes Mellitus, Type 2	1	Biomarker
umls:C0013604	Edema	1	Biomarker
umls:C0018824	Heart Valve Diseases	1	Biomarker
umls:C0027746	Nerve Degeneration	1	Biomarker
umls:C0027765	Nervous System Diseases	1	Biomarker
umls:C0235032	Neurotoxicity Syndromes	1	Biomarker
umls:C0035305	Retinal Detachment	1	Biomarker
umls:C0243026	Sepsis	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for CASP3

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved\|investigational	DB01017	Minocycline	Small molecule
Experimental	DB03124	5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid	Small molecule
Investigational	DB05408	IDN-6556	Small molecule
Experimental	DB06862	2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID	Small molecule
Experimental	DB07696	methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate	Small molecule
Experimental	DB08213	1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE	Small molecule
Experimental	DB08229	[N-(3-DIBENZYLCARBAMOYL-OXIRANECARBONYL)-HYDRAZINO]-ACETIC ACID	Small molecule
Experimental	DB08251	4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID	Small molecule
Experimental	DB08497	(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate	Small molecule
Experimental	DB08498	(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate	Small molecule
Experimental	DB08499	N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CASP3 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
MSI		1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE	1gfw	A	C163
XVE		PHENYLMETHYL N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]CARBAMATE	2xyp	A	C163
RXB		(1S)-2-OXO-1-PHENYL-2-[(1,3,4-TRIOXO-1,2,3,4-TETRAHYDROISOQUINOLIN-5-YL)AMINO]ETHYL ACETATE	3dei	A	C163
RXC		(1S)-1-(3-CHLOROPHENYL)-2-OXO-2-[(1,3,4-TRIOXO-1,2,3,4-TETRAHYDROISOQUINOLIN-5-YL)AMINO]ETHYL ACETATE	3dej	A	C163
H0E		(10S)-3,3-DIMETHYL-8-{[(2S)-2-(PHENOXYMETHYL)PYRROLIDIN-1-YL]SULFONYL}-2,3,4,10-TETRAHYDROPYRIMIDO[1,2-A]INDOL-10-OL	3h0e	A	C163
H0E		(10S)-3,3-DIMETHYL-8-{[(2S)-2-(PHENOXYMETHYL)PYRROLIDIN-1-YL]SULFONYL}-2,3,4,10-TETRAHYDROPYRIMIDO[1,2-A]INDOL-10-OL	3h0e	B	C163
TQ8		CAS329306	2xyg	A	C163 G165
RXD		N-[3-(2-FLUOROETHOXY)PHENYL]-N'-(1,3,4-TRIOXO-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL)BUTANEDIAMIDE	3dek	A	C163 G165
AZI		AZIDE	4qul	A	K137 N141 F193
AZI		AZIDE	4qty	A	K53
AZI		AZIDE	4qu0	A	K53
AZI		AZIDE	4qu9	A	K53
AZI		AZIDE	4qub	A	K53
AZI		AZIDE	4que	A	K53
AZI		AZIDE	4que	C	K53
AZI		AZIDE	4qug	A	K53
AZI		AZIDE	4qug	C	K53
AZI		AZIDE	4quh	C	K53
AZI		AZIDE	4quj	A	K53
AZI		AZIDE	4qul	A	K53
AZI		AZIDE	4qu9	A	N89
III		Peptide ligand (VAL,ASP,ASP,ASP,MET)	4que	A	N89
III		Peptide ligand (VAL,ASP,ASP,ASP,MET)	4que	C	N89
AZI		AZIDE	4qu9	A	R111
III		Peptide ligand (ACE,ASP,VAL,ALA,ASP,CF0)	1cp3	A	R64 Q161 C163
160		3-(3-{2-[(5-METHANESULFONYL-THIOPHENE-2-CARBONYL)-AMINO]-ETHYLDISULFANYLMETHYL}- BENZENESULFONYLAMINO)-4-OXO-PENTANOIC ACID	1nmq	B	R64 Q161 C163
III		Peptide ligand (PHQ,ASP,GLU,VAL,AA1)	2c2k	A	R64 Q161 C163
III		Peptide ligand (PHQ,ASP,GLU,VAL,MX4)	2c2m	A	R64 Q161 C163
III		Peptide ligand (PHQ,ASP,GLU,VAL,MX3)	2c2o	A	R64 Q161 C163
III		Peptide ligand (ASP,GLU,VAL,ASP,0QE)	2cjx	A	R64 Q161 C163
III		Peptide ligand (PHQ,ASP,GLU,VAL,ASP,0QE)	2cjy	A	R64 Q161 C163
III		Peptide ligand (PHQ,ASP,GLU,VAL,MY3)	2cnl	A	R64 Q161 C163
III		Peptide ligand (ASP,GLU,VAL,ASP,0QE)	2dko	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASJ)	2h5i	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,MET,GLN,ASJ)	2h5j	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,MET,GLN,ASJ)	2h5j	C	R64 Q161 C163
III		Peptide ligand (ACE,VAL,ASP,VAL,ALA,ASJ)	2h65	A	R64 Q161 C163
III		Peptide ligand (ACE,VAL,ASP,VAL,ALA,ASJ)	2h65	C	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	2j30	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	2j31	A	R64 Q161 C163
III		Peptide ligand (ASP,GLU,VAL,ASP,0QE)	2j32	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	2j33	A	R64 Q161 C163
III		Peptide ligand (ACE,LEU,ASP,GLU,SER,ASP)	3edq	A	R64 Q161 C163
III		Peptide ligand (ACE,LEU,ASP,GLU,SER,ASP)	3edq	C	R64 Q161 C163
III		Peptide ligand (ACE,TRP,GLU,HIS,ASP)	3gjq	A	R64 Q161 C163
III		Peptide ligand (ACE,TRP,GLU,HIS,ASP)	3gjq	C	R64 Q161 C163
III		Peptide ligand (ACE,TYR,VAL,ALA,ASJ)	3gjs	A	R64 Q161 C163
III		Peptide ligand (ACE,TYR,VAL,ALA,ASJ)	3gjs	C	R64 Q161 C163
III		Peptide ligand (ACE,ILE,GLU,PRO,ASP)	3gjt	A	R64 Q161 C163
III		Peptide ligand (ACE,ILE,GLU,PRO,ASP)	3gjt	C	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	3itn	A	R64 Q161 C163
B92		(3S)-3-({[(5S,10AS)-2-{(2S)-4-CARBOXY-2-[(PHENYLACETYL)AMINO]BUTYL}-1,3-DIOXO-2,3,5,7,8,9,10,10A-OCTAHYDRO-1H-[1,2,4]TRIAZOLO[1,2-A]CINNOLIN-5-YL]CARBONYL}AMINO)-4-OXOPENTANOIC ACID	3kjf	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	3pd0	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASJ)	4dcj	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASJ)	4dco	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASJ)	4dcp	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4eha	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4eha	C	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4ehd	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4ehf	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4ehk	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4ehk	C	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4ehl	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4ehl	C	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4ehn	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qty	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qu8	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qu9	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qua	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qub	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4que	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4que	C	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qug	C	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4quh	C	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qui	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qui	B	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4quj	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qul	A	R64 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qul	C	R64 Q161 C163
III		Peptide ligand (ACE,LEU,GLU,THR,ASP)	4pry	A	R64 Q161 C163
III		Peptide ligand (PHQ,ASP,GLU,VAL,MY1)	2cdr	A	R64 Q161 C163 G165
M60		CBZ-GLU-VAL-AZAASP-(S,S)EP-CO-NHCH2CH2PH	2cno	A	R64 Q161 C163 G165
III		Peptide ligand (ACE,ASP,VAL,ALA,ASP,CF0)	1cp3	B	R64 S120 Q161 C163
158		3-(2-MERCAPTO-ACETYLAMINO)-4-OXO-PENTANOIC ACID	1nme	A	R64 S120 Q161 C163
160		3-(3-{2-[(5-METHANESULFONYL-THIOPHENE-2-CARBONYL)-AMINO]-ETHYLDISULFANYLMETHYL}- BENZENESULFONYLAMINO)-4-OXO-PENTANOIC ACID	1nmq	A	R64 S120 Q161 C163
161		5-[4-(1-CARBOXYMETHYL-2-OXO-PROPYLCARBAMOYL)-BENZYLSULFAMOYL]-2-HYDROXY-BENZOIC ACID	1nms	A	R64 S120 Q161 C163
161		5-[4-(1-CARBOXYMETHYL-2-OXO-PROPYLCARBAMOYL)-BENZYLSULFAMOYL]-2-HYDROXY-BENZOIC ACID	1nms	B	R64 S120 Q161 C163
III		Peptide ligand (PHQ,ASP,GLU,VAL,AA1)	2c1e	A	R64 S120 Q161 C163
III		Peptide ligand (PHQ,ILE,GLU,THR,MY5)	2cnn	A	R64 S120 Q161 C163
TQ9		5-CHLORO-4-OXOPENTANOIC ACID	2xyh	A	R64 S120 Q161 C163
DZE		METHYL (3S)-3-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOPENTANOATE	3gjr	A	R64 S120 Q161 C163
DZE		METHYL (3S)-3-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOPENTANOATE	3gjr	C	R64 S120 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	3pcx	A	R64 S120 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	3pd1	A	R64 S120 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4ehh	A	R64 S120 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4jr0	A	R64 S120 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4jr0	B	R64 S120 Q161 C163
III		Peptide ligand (ACE,1MH,ASP,B3L,HLX,1U8)	4jje	A	R64 S120 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qtx	A	R64 S120 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qu0	A	R64 S120 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qu5	A	R64 S120 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qud	B	R64 S120 Q161 C163
III		Peptide ligand (ACE,ASP,GLU,VAL,ASP,0QE)	4qug	A	R64 S120 Q161 C163
III		Peptide ligand (BAL,LEU,GLN,PRO,1U8)	4ps0	A	R64 S120 Q161 C163
III		Peptide ligand (BAL,LEU,GLN,PRO,1U8)	4ps0	B	R64 S120 Q161 C163
III		Peptide ligand (PHQ,ASP,GLU,VAL,MY2)	2cnk	A	R64 S120 Q161 C163 G165

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Conservation information for LBS of CASP3

Multiple alignments for P42574 in multiple species

LBS	AA sequence	# species	Species
A162	LFIIQACRGTE	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
A221	IQSLCAMLKQY	2	Homo sapiens, Pan troglodytes
A221	IQSLCAMLKLY	2	Rattus norvegicus, Canis lupus familiaris
A221	IQALCEMLKKH	1	Bos taurus
A221	IQSLCSMLKLY	1	Mus musculus
A254	SFSFDATFHAK	2	Homo sapiens, Pan troglodytes
A254	SFSTDSAFHAK	1	Bos taurus
A254	SFSLDSTFHAK	1	Mus musculus
A254	SFSLDATFHAK	1	Rattus norvegicus
A254	SFSLDSAFHGK	1	Canis lupus familiaris
A72	TDVDAANLRET	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
C163	FIIQACRGTEL	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
C220	FIQSLCAMLKQ	2	Homo sapiens, Pan troglodytes
C220	FIQSLCAMLKL	2	Rattus norvegicus, Canis lupus familiaris
C220	FIQALCEMLKK	1	Bos taurus
C220	FIQSLCSMLKL	1	Mus musculus
D211	WRNSKDGSWFI	4	Homo sapiens, Mus musculus, Pan troglodytes, Canis lupus familiaris
D211	WRNAKNGSWFI	1	Bos taurus
D211	WRNSRDGSWFI	1	Rattus norvegicus
D253	ESFSFDATFHA	2	Homo sapiens, Pan troglodytes
D253	ESFSTDSAFHA	1	Bos taurus
D253	ESFSLDSTFHA	1	Mus musculus
D253	ESFSLDATFHA	1	Rattus norvegicus
D253	ESFSLDSAFHG	1	Canis lupus familiaris
D68	SRSGTDVDAAN	3	Homo sapiens, Mus musculus, Pan troglodytes
D68	CRSGTDVDAAN	1	Bos taurus
D68	ARNGTDVDAAN	1	Rattus norvegicus
D68	PRSGTDVDAAN	1	Canis lupus familiaris
E106	RDVSKEDHSKR	2	Homo sapiens, Pan troglodytes
E106	DSVSKEDHSKR	2	Mus musculus, Rattus norvegicus
E106	SNVSKEDHSKR	1	Bos taurus
E106	NSVSKEDHSKR	1	Canis lupus familiaris
E123	LLSHGEEGIIF	3	Homo sapiens, Bos taurus, Pan troglodytes
E123	ILSHGDEGVIY	1	Mus musculus
E123	ILSHGDEGVIF	1	Rattus norvegicus
E123	LLSHGDEGIIF	1	Canis lupus familiaris
E167	ACRGTELDCGI	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
E190	QKIPVEADFLY	4	Bos taurus, Mus musculus, Rattus norvegicus, Canis lupus familiaris
E190	HKIPVEADFLY	2	Homo sapiens, Pan troglodytes
E231	YAHKLEFMHIL	3	Mus musculus, Rattus norvegicus, Canis lupus familiaris
E231	YADKLEFMHIL	2	Homo sapiens, Pan troglodytes
E231	HAHRLELMHIL	1	Bos taurus
E248	VATEFESFSLD	3	Mus musculus, Rattus norvegicus, Canis lupus familiaris
E248	VATEFESFSFD	2	Homo sapiens, Pan troglodytes
E248	VAIEYESFSTD	1	Bos taurus
E43	KMDYPEMGLCI	5	Homo sapiens, Bos taurus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
E43	KMDYPEMGICI	1	Mus musculus
E84	RNLKYEVRNKN	2	Homo sapiens, Pan troglodytes
E84	MNLKYEVRIKN	1	Bos taurus
E84	MGLKYQVRNKN	1	Mus musculus
E84	MALKYEVRNKN	1	Rattus norvegicus
E84	TNLKYEVRNKN	1	Canis lupus familiaris
E94	NDLTREEIVEL	2	Homo sapiens, Pan troglodytes
E94	NDLTCKEMLEL	1	Bos taurus
E94	NDLTREDILEL	1	Mus musculus
E94	NDLTREEIMEL	1	Rattus norvegicus
E94	NDLTCEEILEL	1	Canis lupus familiaris
E95	DLTREEIVELM	2	Homo sapiens, Pan troglodytes
E95	DLTCKEMLELM	1	Bos taurus
E95	DLTREDILELM	1	Mus musculus
E95	DLTREEIMELM	1	Rattus norvegicus
E95	DLTCEEILELM	1	Canis lupus familiaris
F128	EEGIIFGTNGP	3	Homo sapiens, Bos taurus, Pan troglodytes
F128	DEGVIYGTNGP	1	Mus musculus
F128	DEGVIFGTNGP	1	Rattus norvegicus
F128	DEGIIFGTNGP	1	Canis lupus familiaris
F193	PVEADFLYAYS	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
F247	KVATEFESFSL	3	Mus musculus, Rattus norvegicus, Canis lupus familiaris
F247	KVATEFESFSF	2	Homo sapiens, Pan troglodytes
F247	KVAIEYESFST	1	Bos taurus
F250	TEFESFSFDAT	2	Homo sapiens, Pan troglodytes
F250	IEYESFSTDSA	1	Bos taurus
F250	TEFESFSLDST	1	Mus musculus
F250	TEFESFSLDAT	1	Rattus norvegicus
F250	TEFESFSLDSA	1	Canis lupus familiaris
F252	FESFSFDATFH	2	Homo sapiens, Pan troglodytes
F252	YESFSTDSAFH	1	Bos taurus
F252	FESFSLDSTFH	1	Mus musculus
F252	FESFSLDATFH	1	Rattus norvegicus
F252	FESFSLDSAFH	1	Canis lupus familiaris
F256	SFDATFHAKKQ	2	Homo sapiens, Pan troglodytes
F256	STDSAFHAKKQ	1	Bos taurus
F256	SLDSTFHAKKQ	1	Mus musculus
F256	SLDATFHAKKQ	1	Rattus norvegicus
F256	SLDSAFHGKKQ	1	Canis lupus familiaris
G122	VLLSHGEEGII	3	Homo sapiens, Bos taurus, Pan troglodytes
G122	VILSHGDEGVI	2	Mus musculus, Rattus norvegicus
G122	VLLSHGDEGII	1	Canis lupus familiaris
G165	IQACRGTELDC	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
G66	MTSRSGTDVDA	2	Homo sapiens, Pan troglodytes
G66	MACRSGTDVDA	1	Bos taurus
G66	MSSRSGTDVDA	1	Mus musculus
G66	MSARNGTDVDA	1	Rattus norvegicus
G66	MAPRSGTDVDA	1	Canis lupus familiaris
H121	CVLLSHGEEGI	3	Homo sapiens, Bos taurus, Pan troglodytes
H121	CVILSHGDEGV	2	Mus musculus, Rattus norvegicus
H121	CVLLSHGDEGI	1	Canis lupus familiaris
H234	KLEFMHILTRV	5	Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
H234	RLELMHILTRV	1	Bos taurus
K137	GPVDLKKITNF	2	Homo sapiens, Pan troglodytes
K137	GPVNLKKLASF	1	Bos taurus
K137	GPVELKKLTSF	1	Mus musculus
K137	GPVDLKKLTSF	1	Rattus norvegicus
K137	GPVDLRKVTGF	1	Canis lupus familiaris
K210	SWRNSKDGSWF	4	Homo sapiens, Mus musculus, Pan troglodytes, Canis lupus familiaris
K210	SWRNAKNGSWF	1	Bos taurus
K210	SWRNSRDGSWF	1	Rattus norvegicus
K229	KLYAHKLEFMH	3	Mus musculus, Rattus norvegicus, Canis lupus familiaris
K229	KQYADKLEFMH	2	Homo sapiens, Pan troglodytes
K229	KKHAHRLELMH	1	Bos taurus
K53	IIINNKNFHKS	5	Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
K53	IIINNKNFHEN	1	Bos taurus
K88	YEVRNKNDLTR	3	Homo sapiens, Rattus norvegicus, Pan troglodytes
K88	YEVRIKNDLTC	1	Bos taurus
K88	YQVRNKNDLTR	1	Mus musculus
K88	YEVRNKNDLTC	1	Canis lupus familiaris
L168	CRGTELDCGIE	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
L230	LYAHKLEFMHI	3	Mus musculus, Rattus norvegicus, Canis lupus familiaris
L230	QYADKLEFMHI	2	Homo sapiens, Pan troglodytes
L230	KHAHRLELMHI	1	Bos taurus
L81	ETFRNLKYEVR	2	Homo sapiens, Pan troglodytes
L81	ETFMNLKYEVR	1	Bos taurus
L81	ETFMGLKYQVR	1	Mus musculus
L81	ETFMALKYEVR	1	Rattus norvegicus
L81	ETFTNLKYEVR	1	Canis lupus familiaris
M61	HKSTGMTSRSG	2	Homo sapiens, Pan troglodytes
M61	HENTGMACRSG	1	Bos taurus
M61	HKSTGMSSRSG	1	Mus musculus
M61	HKSTGMSARNG	1	Rattus norvegicus
M61	HKSTGMAPRSG	1	Canis lupus familiaris
N141	LKKITNFFRGD	2	Homo sapiens, Pan troglodytes
N141	LKKLTSFFRGD	2	Mus musculus, Rattus norvegicus
N141	LKKLASFFRGD	1	Bos taurus
N141	LRKVTGFFRGD	1	Canis lupus familiaris
N208	YYSWRNSKDGS	4	Homo sapiens, Mus musculus, Pan troglodytes, Canis lupus familiaris
N208	YFSWRNAKNGS	1	Bos taurus
N208	YYSWRNSRDGS	1	Rattus norvegicus
N73	DVDAANLRETF	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
N80	RETFRNLKYEV	2	Homo sapiens, Pan troglodytes
N80	RETFMNLKYEV	1	Bos taurus
N80	RETFMGLKYQV	1	Mus musculus
N80	RETFMALKYEV	1	Rattus norvegicus
N80	RETFTNLKYEV	1	Canis lupus familiaris
N87	KYEVRNKNDLT	4	Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
N87	KYEVRIKNDLT	1	Bos taurus
N87	KYQVRNKNDLT	1	Mus musculus
N89	EVRNKNDLTRE	3	Homo sapiens, Rattus norvegicus, Pan troglodytes
N89	EVRIKNDLTCK	1	Bos taurus
N89	QVRNKNDLTRE	1	Mus musculus
N89	EVRNKNDLTCE	1	Canis lupus familiaris
Q161	KLFIIQACRGT	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
Q217	GSWFIQSLCAM	4	Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
Q217	GSWFIQALCEM	1	Bos taurus
Q217	GSWFIQSLCSM	1	Mus musculus
R111	EDHSKRSSFVC	5	Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
R111	EDHSKRSSFIC	1	Bos taurus
R207	GYYSWRNSKDG	4	Homo sapiens, Mus musculus, Pan troglodytes, Canis lupus familiaris
R207	GYFSWRNAKNG	1	Bos taurus
R207	GYYSWRNSRDG	1	Rattus norvegicus
R64	TGMTSRSGTDV	2	Homo sapiens, Pan troglodytes
R64	TGMACRSGTDV	1	Bos taurus
R64	TGMSSRSGTDV	1	Mus musculus
R64	TGMSARNGTDV	1	Rattus norvegicus
R64	TGMAPRSGTDV	1	Canis lupus familiaris
R75	DAANLRETFRN	2	Homo sapiens, Pan troglodytes
R75	DAANLRETFMN	1	Bos taurus
R75	DAANLRETFMG	1	Mus musculus
R75	DAANLRETFMA	1	Rattus norvegicus
R75	DAANLRETFTN	1	Canis lupus familiaris
R86	LKYEVRNKNDL	4	Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
R86	LKYEVRIKNDL	1	Bos taurus
R86	LKYQVRNKNDL	1	Mus musculus
S120	VCVLLSHGEEG	2	Homo sapiens, Pan troglodytes
S120	VCVILSHGDEG	2	Mus musculus, Rattus norvegicus
S120	ICVLLSHGEEG	1	Bos taurus
S120	VCVLLSHGDEG	1	Canis lupus familiaris
S205	APGYYSWRNSK	4	Homo sapiens, Mus musculus, Pan troglodytes, Canis lupus familiaris
S205	APGYFSWRNAK	1	Bos taurus
S205	APGYYSWRNSR	1	Rattus norvegicus
S209	YSWRNSKDGSW	4	Homo sapiens, Mus musculus, Pan troglodytes, Canis lupus familiaris
S209	FSWRNAKNGSW	1	Bos taurus
S209	YSWRNSRDGSW	1	Rattus norvegicus
S249	ATEFESFSFDA	2	Homo sapiens, Pan troglodytes
S249	ATEFESFSLDS	2	Mus musculus, Canis lupus familiaris
S249	AIEYESFSTDS	1	Bos taurus
S249	ATEFESFSLDA	1	Rattus norvegicus
S251	EFESFSFDATF	2	Homo sapiens, Pan troglodytes
S251	EYESFSTDSAF	1	Bos taurus
S251	EFESFSLDSTF	1	Mus musculus
S251	EFESFSLDATF	1	Rattus norvegicus
S251	EFESFSLDSAF	1	Canis lupus familiaris
S63	STGMTSRSGTD	2	Homo sapiens, Pan troglodytes
S63	NTGMACRSGTD	1	Bos taurus
S63	STGMSSRSGTD	1	Mus musculus
S63	STGMSARNGTD	1	Rattus norvegicus
S63	STGMAPRSGTD	1	Canis lupus familiaris
S65	GMTSRSGTDVD	2	Homo sapiens, Pan troglodytes
S65	GMACRSGTDVD	1	Bos taurus
S65	GMSSRSGTDVD	1	Mus musculus
S65	GMSARNGTDVD	1	Rattus norvegicus
S65	GMAPRSGTDVD	1	Canis lupus familiaris
T140	DLKKITNFFRG	2	Homo sapiens, Pan troglodytes
T140	NLKKLASFFRG	1	Bos taurus
T140	ELKKLTSFFRG	1	Mus musculus
T140	DLKKLTSFFRG	1	Rattus norvegicus
T140	DLRKVTGFFRG	1	Canis lupus familiaris
T166	QACRGTELDCG	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
T255	FSFDATFHAKK	2	Homo sapiens, Pan troglodytes
T255	FSTDSAFHAKK	1	Bos taurus
T255	FSLDSTFHAKK	1	Mus musculus
T255	FSLDATFHAKK	1	Rattus norvegicus
T255	FSLDSAFHGKK	1	Canis lupus familiaris
T67	TSRSGTDVDAA	2	Homo sapiens, Pan troglodytes
T67	ACRSGTDVDAA	1	Bos taurus
T67	SSRSGTDVDAA	1	Mus musculus
T67	SARNGTDVDAA	1	Rattus norvegicus
T67	APRSGTDVDAA	1	Canis lupus familiaris
T92	NKNDLTREEIV	2	Homo sapiens, Pan troglodytes
T92	IKNDLTCKEML	1	Bos taurus
T92	NKNDLTREDIL	1	Mus musculus
T92	NKNDLTREEIM	1	Rattus norvegicus
T92	NKNDLTCEEIL	1	Canis lupus familiaris
V69	RSGTDVDAANL	5	Homo sapiens, Bos taurus, Mus musculus, Pan troglodytes, Canis lupus familiaris
V69	RNGTDVDAANL	1	Rattus norvegicus
W206	PGYYSWRNSKD	4	Homo sapiens, Mus musculus, Pan troglodytes, Canis lupus familiaris
W206	PGYFSWRNAKN	1	Bos taurus
W206	PGYYSWRNSRD	1	Rattus norvegicus
W214	SKDGSWFIQSL	4	Homo sapiens, Mus musculus, Pan troglodytes, Canis lupus familiaris
W214	AKNGSWFIQAL	1	Bos taurus
W214	SRDGSWFIQSL	1	Rattus norvegicus
Y195	EADFLYAYSTA	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
Y204	TAPGYYSWRNS	5	Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
Y204	TAPGYFSWRNA	1	Bos taurus