mutLBSgeneDB |
Gene summary for ZNF484 |
Gene summary |
Basic gene Info. | Gene symbol | ZNF484 |
Gene name | zinc finger protein 484 | |
Synonyms | BA526D8.4 | |
Cytomap | UCSC genome browser: 9q22.31 | |
Type of gene | protein-coding | |
RefGenes | NM_001007101.2, NM_001261458.1,NM_001261459.1,NM_001261460.1,NM_031486.2, | |
Description | KRAB box containing C2H2 type zinc finger bA526D8.4 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000127081 | ||
HPRD : 18346 | ||
Vega : OTTHUMG00000020236 | ||
Protein | UniProt: Q5JVG2 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZNF484 | |
BioGPS: 83744 | ||
Pathway | NCI Pathway Interaction Database: ZNF484 | |
KEGG: ZNF484 | ||
REACTOME: ZNF484 | ||
Pathway Commons: ZNF484 | ||
Context | iHOP: ZNF484 | |
ligand binding site mutation search in PubMed: ZNF484 | ||
UCL Cancer Institute: ZNF484 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ZNF484 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | C722 | C722Y | COAD | 1 | H682 | H682Q | HNSC | 1 | C442 | S443I | LUAD | 1 | C473 | E472Q | LUAD | 1 | H490 | H490Y | SKCM | 1 | H490 | H490N | UCEC | 1 | H798 | I797S | UCEC | 1 | H490 | K488N | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ZNF484 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H798 | I797S | -1.4959896 | H490 | H490N | -1.2273321 | H490 | K488N | -1.0170724 | H490 | H490Y | -0.92027184 | H682 | H682Q | -0.90291278 | C473 | E472Q | -0.71170792 | C722 | C722Y | -0.6956228 | C442 | S443I | -0.56018879 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ZNF484 from PDB |
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Differential gene expression and gene-gene network for ZNF484 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ZNF484 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ZNF484 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ZNF484 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ZNF484 |
Multiple alignments for Q5JVG2 in multiple species |
LBS | AA sequence | # species | Species |
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