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mutLBSgeneDB |
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| Gene summary for TAF3 |
 Gene summary |
| Basic gene Info. | Gene symbol | TAF3 |
| Gene name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | |
| Synonyms | TAF140|TAFII-140|TAFII140 | |
| Cytomap | UCSC genome browser: 10p15.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_031923.3, | |
| Description | 140 kDa TATA box-binding protein-associated factorRNA polymerase II transcription factor TAFII140TAF(II)140TBP-associated factor 3transcription initiation factor TFIID 140 kDa subunittranscription initiation factor TFIID subunit 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606576 | |
| HGNC : HGNC | ||
| Protein | UniProt: Q5VWG9 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TAF3 | |
| BioGPS: 83860 | ||
| Pathway | NCI Pathway Interaction Database: TAF3 | |
| KEGG: TAF3 | ||
| REACTOME: TAF3 | ||
| Pathway Commons: TAF3 | ||
| Context | iHOP: TAF3 | |
| ligand binding site mutation search in PubMed: TAF3 | ||
| UCL Cancer Institute: TAF3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 18549481 | GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 18549481 | GO:0051457 | maintenance of protein location in nucleus | 15870280 |
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| Ligand binding site mutations for TAF3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E860 | G862S | KIRC | 1 | M905 | M905I | LUAD | 1 | W866 | Q864H | LUSC | 1 | H891,W889 | Y890H | STAD | 1 | E860 | G862D | STAD | 1 | D884,C886 | D885N | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TAF3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H891 | Y890H | -1.5015364 | W889 | Y890H | -1.5015364 | D884 | D885N | -0.97108621 | C886 | D885N | -0.97108621 | E860 | G862S | -0.80530644 | E860 | G862D | -0.76016361 | M905 | M905I | -0.68766591 | W866 | Q864H | -0.24294166 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TAF3 from PDB |
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| Differential gene expression and gene-gene network for TAF3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TAF3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TAF3 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TAF3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of TAF3 |
| Multiple alignments for Q5VWG9 in multiple species |
| LBS | AA sequence | # species | Species | C2 | 3 | Homo sapiens, Gallus gallus, Mus musculus | C868 | NQIWICPGCNK | 2 | Homo sapiens, Mus musculus | C868 | NQIWFCPGCNK | 1 | Gallus gallus | C871 | WICPGCNKPDD | 2 | Homo sapiens, Mus musculus | C871 | WFCPGCNKPDD | 1 | Gallus gallus | C883 | SPMIGCDDCDD | 3 | Homo sapiens, Gallus gallus, Mus musculus | C886 | IGCDDCDDWYH | 3 | Homo sapiens, Gallus gallus, Mus musculus | C894 | WYHWPCVGIMT | 1 | Homo sapiens | C894 | WYHWPCVGITA | 1 | Gallus gallus | C894 | WYHWPCVGIMA | 1 | Mus musculus | C909 | EMQWFCPKCAN | 2 | Homo sapiens, Mus musculus | C909 | EMQWFCSKCAN | 1 | Gallus gallus | D884 | PMIGCDDCDDW | 3 | Homo sapiens, Gallus gallus, Mus musculus | D887 | GCDDCDDWYHW | 3 | Homo sapiens, Gallus gallus, Mus musculus | E860 | YVIRDEWGNQI | 3 | Homo sapiens, Gallus gallus, Mus musculus | E903 | MTAPPEEMQWF | 1 | Homo sapiens | E903 | TAAPPEEMQWF | 1 | Gallus gallus | E903 | MAAPPEEMQWF | 1 | Mus musculus | F908 | EEMQWFCPKCA | 2 | Homo sapiens, Mus musculus | F908 | EEMQWFCSKCA | 1 | Gallus gallus | G882 | GSPMIGCDDCD | 3 | Homo sapiens, Gallus gallus, Mus musculus | H891 | CDDWYHWPCVG | 3 | Homo sapiens, Gallus gallus, Mus musculus | I857 | VSTYVIRDEWG | 3 | Homo sapiens, Gallus gallus, Mus musculus | I881 | DGSPMIGCDDC | 3 | Homo sapiens, Gallus gallus, Mus musculus | M880 | DDGSPMIGCDD | 3 | Homo sapiens, Gallus gallus, Mus musculus | M905 | APPEEMQWFCP | 2 | Homo sapiens, Mus musculus | M905 | APPEEMQWFCS | 1 | Gallus gallus | N872 | ICPGCNKPDDG | 2 | Homo sapiens, Mus musculus | N872 | FCPGCNKPDDG | 1 | Gallus gallus | P879 | PDDGSPMIGCD | 3 | Homo sapiens, Gallus gallus, Mus musculus | P901 | GIMTAPPEEMQ | 1 | Homo sapiens | P901 | GITAAPPEEMQ | 1 | Gallus gallus | P901 | GIMAAPPEEMQ | 1 | Mus musculus | P902 | IMTAPPEEMQW | 1 | Homo sapiens | P902 | ITAAPPEEMQW | 1 | Gallus gallus | P902 | IMAAPPEEMQW | 1 | Mus musculus | R858 | STYVIRDEWGN | 3 | Homo sapiens, Gallus gallus, Mus musculus | V856 | TVSTYVIRDEW | 3 | Homo sapiens, Gallus gallus, Mus musculus | W866 | WGNQIWICPGC | 2 | Homo sapiens, Mus musculus | W866 | WGNQIWFCPGC | 1 | Gallus gallus | W889 | DDCDDWYHWPC | 3 | Homo sapiens, Gallus gallus, Mus musculus | W892 | DDWYHWPCVGI | 3 | Homo sapiens, Gallus gallus, Mus musculus | W907 | PEEMQWFCPKC | 2 | Homo sapiens, Mus musculus | W907 | PEEMQWFCSKC | 1 | Gallus gallus | Y855 | ETVSTYVIRDE | 3 | Homo sapiens, Gallus gallus, Mus musculus |
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