mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TAF3
Gene summary
Basic gene Info.Gene symbolTAF3
Gene nameTAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
CytomapUCSC genome browser: 10p15.1
Type of geneprotein-coding
Description140 kDa TATA box-binding protein-associated factorRNA polymerase II transcription factor TAFII140TAF(II)140TBP-associated factor 3transcription initiation factor TFIID 140 kDa subunittranscription initiation factor TFIID subunit 3
Modification date20141207
dbXrefs MIM : 606576
ProteinUniProt: Q5VWG9
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TAF3
BioGPS: 83860
PathwayNCI Pathway Interaction Database: TAF3
Pathway Commons: TAF3
ContextiHOP: TAF3
ligand binding site mutation search in PubMed: TAF3
UCL Cancer Institute: TAF3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0000122negative regulation of transcription from RNA polymerase II promoter18549481
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity18549481
GO:0051457maintenance of protein location in nucleus15870280

Ligand binding site mutations for TAF3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for TAF3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TAF3 from PDB

Differential gene expression and gene-gene network for TAF3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TAF3 and the right PPI network was created from samples without mutations in the LBS of TAF3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for TAF3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for TAF3
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TAF3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of TAF3
Multiple alignments for Q5VWG9 in multiple species
LBSAA sequence# speciesSpecies
C23Homo sapiens, Gallus gallus, Mus musculus
C868NQIWICPGCNK2Homo sapiens, Mus musculus
C868NQIWFCPGCNK1Gallus gallus
C871WICPGCNKPDD2Homo sapiens, Mus musculus
C871WFCPGCNKPDD1Gallus gallus
C883SPMIGCDDCDD3Homo sapiens, Gallus gallus, Mus musculus
C886IGCDDCDDWYH3Homo sapiens, Gallus gallus, Mus musculus
C894WYHWPCVGIMT1Homo sapiens
C894WYHWPCVGITA1Gallus gallus
C894WYHWPCVGIMA1Mus musculus
C909EMQWFCPKCAN2Homo sapiens, Mus musculus
C909EMQWFCSKCAN1Gallus gallus
D884PMIGCDDCDDW3Homo sapiens, Gallus gallus, Mus musculus
D887GCDDCDDWYHW3Homo sapiens, Gallus gallus, Mus musculus
E860YVIRDEWGNQI3Homo sapiens, Gallus gallus, Mus musculus
E903MTAPPEEMQWF1Homo sapiens
E903TAAPPEEMQWF1Gallus gallus
E903MAAPPEEMQWF1Mus musculus
F908EEMQWFCPKCA2Homo sapiens, Mus musculus
F908EEMQWFCSKCA1Gallus gallus
G882GSPMIGCDDCD3Homo sapiens, Gallus gallus, Mus musculus
H891CDDWYHWPCVG3Homo sapiens, Gallus gallus, Mus musculus
I857VSTYVIRDEWG3Homo sapiens, Gallus gallus, Mus musculus
I881DGSPMIGCDDC3Homo sapiens, Gallus gallus, Mus musculus
M880DDGSPMIGCDD3Homo sapiens, Gallus gallus, Mus musculus
M905APPEEMQWFCP2Homo sapiens, Mus musculus
M905APPEEMQWFCS1Gallus gallus
N872ICPGCNKPDDG2Homo sapiens, Mus musculus
N872FCPGCNKPDDG1Gallus gallus
P879PDDGSPMIGCD3Homo sapiens, Gallus gallus, Mus musculus
P901GIMTAPPEEMQ1Homo sapiens
P901GITAAPPEEMQ1Gallus gallus
P901GIMAAPPEEMQ1Mus musculus
P902IMTAPPEEMQW1Homo sapiens
P902ITAAPPEEMQW1Gallus gallus
P902IMAAPPEEMQW1Mus musculus
R858STYVIRDEWGN3Homo sapiens, Gallus gallus, Mus musculus
V856TVSTYVIRDEW3Homo sapiens, Gallus gallus, Mus musculus
W866WGNQIWICPGC2Homo sapiens, Mus musculus
W866WGNQIWFCPGC1Gallus gallus
W889DDCDDWYHWPC3Homo sapiens, Gallus gallus, Mus musculus
W892DDWYHWPCVGI3Homo sapiens, Gallus gallus, Mus musculus
W907PEEMQWFCPKC2Homo sapiens, Mus musculus
W907PEEMQWFCSKC1Gallus gallus
Y855ETVSTYVIRDE3Homo sapiens, Gallus gallus, Mus musculus

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