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mutLBSgeneDB |
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| Gene summary for PIP4K2B |
 Gene summary |
| Basic gene Info. | Gene symbol | PIP4K2B |
| Gene name | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | |
| Synonyms | PI5P4KB|PIP5K2B|PIP5KIIB|PIP5KIIbeta | |
| Cytomap | UCSC genome browser: 17q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003559.4, NM_138687.1, | |
| Description | 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta1-phosphatidylinositol-4-phosphate kinase1-phosphatidylinositol-5-phosphate 4-kinase 2-betaPI(5)P 4-kinase type II betaPIP4KII-betaPTDINS(4)P-5-kinasediphosphoinositide kinase 2-betaphosphatidylinos | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603261 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000276293 | ||
| HPRD : 04463 | ||
| Vega : OTTHUMG00000188504 | ||
| Protein | UniProt: P78356 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PIP4K2B | |
| BioGPS: 8396 | ||
| Pathway | NCI Pathway Interaction Database: PIP4K2B | |
| KEGG: PIP4K2B | ||
| REACTOME: PIP4K2B | ||
| Pathway Commons: PIP4K2B | ||
| Context | iHOP: PIP4K2B | |
| ligand binding site mutation search in PubMed: PIP4K2B | ||
| UCL Cancer Institute: PIP4K2B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0046854 | phosphatidylinositol phosphorylation | 9038203 |
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| Ligand binding site mutations for PIP4K2B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V148 | R146H | COAD | 2 | N162 | I163V | COAD | 1 | K214 | R213H | LUAD | 1 | K96 | K96Q | LUSC | 1 | V157 | V157L | OV | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PIP4K2B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V148 | R146H | -1.6242311 | K214 | R213H | -1.2544399 | N162 | I163V | -0.98266106 | K96 | K96Q | -0.55172865 | V157 | V157L | -0.32135604 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PIP4K2B from PDB |
| PDB ID | PDB title | PDB structure | 1BO1 | PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA |  |
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| Differential gene expression and gene-gene network for PIP4K2B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PIP4K2B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PIP4K2B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PIP4K2B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 5GP | GMP RESIDUE | 3x02 | A | K214 | AMP | AMP | 3x05 | A | K214 | ANP | AMP-PNP | 3x03 | A | K96 | AMP | AMP | 3x05 | A | K96 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 3x04 | A | K96 N162 | AMP | AMP | 3x01 | A | K96 V157 | 5GP | GMP RESIDUE | 3x02 | A | K96 V157 | AMP | AMP | 3x05 | B | K96 V157 | AMP | AMP | 3x07 | A | K96 V157 | AMP | AMP | 3x09 | A | K96 V157 | 5GP | GMP RESIDUE | 3x0a | B | K96 V157 | AMP | AMP | 3x0b | A | K96 V157 | 5GP | GMP RESIDUE | 3x06 | A | K96 V157 N162 | 5GP | GMP RESIDUE | 3x08 | A | K96 V157 N162 | 5GP | GMP RESIDUE | 3x0a | A | K96 V157 N162 | 5GP | GMP RESIDUE | 3x0c | A | K96 V157 N162 | 5GP | GMP RESIDUE | 3x0c | B | K96 V157 N162 | 5GP | GMP RESIDUE | 3x06 | A | N162 | 5GP | GMP RESIDUE | 3x08 | A | N162 | ANP | AMP-PNP | 3x03 | B | V148 | AMP | AMP | 3x0b | B | V148 | AMP | AMP | 3x01 | A | V148 K214 | AMP | AMP | 3x01 | B | V148 K214 | 5GP | GMP RESIDUE | 3x02 | B | V148 K214 | ANP | AMP-PNP | 3x03 | A | V148 K214 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 3x04 | A | V148 K214 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 3x04 | B | V148 K214 | AMP | AMP | 3x05 | B | V148 K214 | 5GP | GMP RESIDUE | 3x06 | A | V148 K214 | 5GP | GMP RESIDUE | 3x06 | B | V148 K214 | AMP | AMP | 3x07 | A | V148 K214 | AMP | AMP | 3x09 | A | V148 K214 | AMP | AMP | 3x09 | B | V148 K214 | 5GP | GMP RESIDUE | 3x0a | A | V148 K214 | 5GP | GMP RESIDUE | 3x0a | B | V148 K214 | AMP | AMP | 3x0b | A | V148 K214 | 5GP | GMP RESIDUE | 3x0c | A | V148 K214 |
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| Conservation information for LBS of PIP4K2B |
| Multiple alignments for P78356 in multiple species |
| LBS | AA sequence | # species | Species | A158 | SSEDVAEMHNI | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | D216 | VHRKYDLKGST | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | D369 | FMAIIDILTPY | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | E195 | TVDGVETYMVV | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | E297 | EQEEMEVEERA | 2 | Homo sapiens, Mus musculus | E297 | EQEETEVEDRA | 1 | Rattus norvegicus | F139 | RCGTRFLTTYD | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | F205 | VTRNVFSHRLT | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | F71 | LMPDDFKAYSK | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | H161 | DVAEMHNILKK | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | I368 | YFMAIIDILTP | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | K150 | RRFVIKTVSSE | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | K214 | LTVHRKYDLKG | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | K72 | MPDDFKAYSKI | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | K96 | SRFKFKEYCPM | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | L282 | MDYSLLVGIHD | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | M296 | AEQEEMEVEER | 2 | Homo sapiens, Mus musculus | M296 | AEQEETEVEDR | 1 | Rattus norvegicus | N162 | VAEMHNILKKY | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | N203 | MVVTRNVFSHR | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | Q293 | VDRAEQEEMEV | 2 | Homo sapiens, Mus musculus | Q293 | VDRAEQEETEV | 1 | Rattus norvegicus | R188 | FLGMYRLTVDG | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | R202 | YMVVTRNVFSH | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | S154 | IKTVSSEDVAE | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | T201 | TYMVVTRNVFS | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | T237 | AKDLPTFKDND | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | V148 | YDRRFVIKTVS | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | V157 | VSSEDVAEMHN | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | V204 | VVTRNVFSHRL | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | Y197 | DGVETYMVVTR | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | Y98 | FKFKEYCPMVF | 3 | Homo sapiens, Rattus norvegicus, Mus musculus |
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