mutLBSgeneDB |
Gene summary for BCAR3 |
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Basic gene Info. | Gene symbol | BCAR3 |
Gene name | breast cancer anti-estrogen resistance 3 | |
Synonyms | NSP2|SH2D3B | |
Cytomap | UCSC genome browser: 1p22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001261408.1, NM_001261409.1,NM_001261410.1,NM_003567.3, | |
Description | SH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance protein 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistance 3)novel SH2-containing protein 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604704 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137936 | ||
HPRD : 05268 | ||
Vega : OTTHUMG00000010301 | ||
Protein | UniProt: O75815 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BCAR3 | |
BioGPS: 8412 | ||
Pathway | NCI Pathway Interaction Database: BCAR3 | |
KEGG: BCAR3 | ||
REACTOME: BCAR3 | ||
Pathway Commons: BCAR3 | ||
Context | iHOP: BCAR3 | |
ligand binding site mutation search in PubMed: BCAR3 | ||
UCL Cancer Institute: BCAR3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for BCAR3 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | N742 | M740V | COAD | 1 | N742 | H743R | KIRC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for BCAR3 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | N742 | M740V | -1.1537882 | N742 | H743R | -0.45466665 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for BCAR3 |
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Phenotype information for BCAR3 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C1458155 | Breast Neoplasms | 4 | AlteredExpression, Biomarker |
umls:C0236969 | Substance-Related Disorders | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for BCAR3 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | POG | POLY(PROPYLENE GLYCOL) MACROMOLECULE | 3t6a | B | N742 |
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Conservation information for LBS of BCAR3 |
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LBS | AA sequence | # species | Species | A745 | MLNHLATARFM | 1 | Homo sapiens | A745 | LLNHLATARFM | 1 | Mus musculus | A745 | MLNHLATARLM | 1 | Bos taurus | F749 | LATARFMAEAA | 1 | Homo sapiens | F749 | LATARFMAEAS | 1 | Mus musculus | F749 | LATARLMAEAA | 1 | Bos taurus | N742 | CEIMLNHLATA | 2 | Homo sapiens, Bos taurus | N742 | CEILLNHLATA | 1 | Mus musculus | T746 | LNHLATARFMA | 2 | Homo sapiens, Mus musculus | T746 | LNHLATARLMA | 1 | Bos taurus |
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