mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ACAD11
Gene summary
Basic gene Info.Gene symbolACAD11
Gene nameacyl-CoA dehydrogenase family, member 11
CytomapUCSC genome browser: 3q22.1
Type of geneprotein-coding
Description62113 proteinacyl-CoA dehydrogenase family member 11acyl-Coenzyme A dehydrogenase family, member 11
Modification date20141207
dbXrefs MIM : 614288
Ensembl : ENSG00000240303
HPRD : 13352
Vega : OTTHUMG00000159780
ProteinUniProt: Q709F0
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ACAD11
BioGPS: 84129
PathwayNCI Pathway Interaction Database: ACAD11
Pathway Commons: ACAD11
ContextiHOP: ACAD11
ligand binding site mutation search in PubMed: ACAD11
UCL Cancer Institute: ACAD11
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0033539fatty acid beta-oxidation using acyl-CoA dehydrogenase21237683

Ligand binding site mutations for ACAD11

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ACAD11
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ACAD11 from PDB

Differential gene expression and gene-gene network for ACAD11
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ACAD11 and the right PPI network was created from samples without mutations in the LBS of ACAD11. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ACAD11
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ACAD11
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ACAD11 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ACAD11
Multiple alignments for Q709F0 in multiple species
LBSAA sequence# speciesSpecies
A512TEPDVASSDAT2Homo sapiens, Gallus gallus
A512TEPNVSSSDAT2Mus musculus, Rattus norvegicus
E758ADGPDEVHLSA3Homo sapiens, Mus musculus, Rattus norvegicus
E758ADGPDEVHLST1Gallus gallus
F504DITSVFCMTEP2Mus musculus, Rattus norvegicus
F504NITSCFCMTEP1Homo sapiens
F504KISSCFCMTEP1Gallus gallus
F660TQRIAFKKKLY1Homo sapiens
F660AQRETFGKKLY1Gallus gallus
F660VQREAFKKKLY1Mus musculus
F660VQREAFGKKLY1Rattus norvegicus
G730AIQVCGGAGVS2Homo sapiens, Gallus gallus
G730AIQVHGGAGVS2Mus musculus, Rattus norvegicus
G731IQVCGGAGVSQ2Homo sapiens, Gallus gallus
G731IQVHGGAGVSQ2Mus musculus, Rattus norvegicus
H598NFHGGHFEIHF1Homo sapiens
H598EIHGGHFEVHF1Gallus gallus
H598NMHGGHWEVHF1Mus musculus
H598NVHGGHWEVHF1Rattus norvegicus
H667KKLYEHEVVAH2Mus musculus, Rattus norvegicus
H667KKLYAHEVVAH1Homo sapiens
H667KKLYHHEVVAH1Gallus gallus
L664AFKKKLYAHEV1Homo sapiens
L664TFGKKLYHHEV1Gallus gallus
L664AFKKKLYEHEV1Mus musculus
L664AFGKKLYEHEV1Rattus norvegicus
L752IRTLRLADGPD2Mus musculus, Rattus norvegicus
L752TRVLRLADGPD1Homo sapiens
L752IRTLRVADGPD1Gallus gallus
M506TSVFCMTEPNV2Mus musculus, Rattus norvegicus
M506TSCFCMTEPDV1Homo sapiens
M506SSCFCMTEPDV1Gallus gallus
P756RLADGPDEVHL3Homo sapiens, Mus musculus, Rattus norvegicus
P756RVADGPDEVHL1Gallus gallus
Q727VDWAIQVCGGA1Homo sapiens
Q727IDCAIQVCGGA1Gallus gallus
Q727ADWAIQVHGGA1Mus musculus
Q727ADRAIQVHGGA1Rattus norvegicus
R657ERATQRIAFKK1Homo sapiens
R657QRAAQRETFGK1Gallus gallus
R657DRAVQREAFKK1Mus musculus
R657DRAVQREAFGK1Rattus norvegicus
S513EPDVASSDATN2Homo sapiens, Gallus gallus
S513EPNVSSSDATN2Mus musculus, Rattus norvegicus
S514PDVASSDATNI1Homo sapiens
S514PDVASSDATNM1Gallus gallus
S514PNVSSSDATNI1Mus musculus
S514PNVSSSDATNM1Rattus norvegicus
S540KKWWSSGAGNP4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
T507SCFCMTEPDVA2Homo sapiens, Gallus gallus
T507SVFCMTEPNVS2Mus musculus, Rattus norvegicus
V728DWAIQVCGGAG1Homo sapiens
V728DCAIQVCGGAG1Gallus gallus
V728DWAIQVHGGAG1Mus musculus
V728DRAIQVHGGAG1Rattus norvegicus
V734HGGAGVSQDYP2Mus musculus, Rattus norvegicus
V734CGGAGVSQDYP1Homo sapiens
V734CGGAGVSQDFP1Gallus gallus
V749YAIIRTLRLAD2Mus musculus, Rattus norvegicus
V749YAITRVLRLAD1Homo sapiens
V749FAYIRTLRVAD1Gallus gallus
V759DGPDEVHLSAI3Homo sapiens, Mus musculus, Rattus norvegicus
V759DGPDEVHLSTI1Gallus gallus
W538NGKKWWSSGAG3Homo sapiens, Gallus gallus, Mus musculus
W538HGKKWWSSGAG1Rattus norvegicus

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