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mutLBSgeneDB |
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| Gene summary for ACAD11 |
 Gene summary |
| Basic gene Info. | Gene symbol | ACAD11 |
| Gene name | acyl-CoA dehydrogenase family, member 11 | |
| Synonyms | ACAD-11 | |
| Cytomap | UCSC genome browser: 3q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032169.4, | |
| Description | 62113 proteinacyl-CoA dehydrogenase family member 11acyl-Coenzyme A dehydrogenase family, member 11 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 614288 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000240303 | ||
| HPRD : 13352 | ||
| Vega : OTTHUMG00000159780 | ||
| Protein | UniProt: Q709F0 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ACAD11 | |
| BioGPS: 84129 | ||
| Pathway | NCI Pathway Interaction Database: ACAD11 | |
| KEGG: ACAD11 | ||
| REACTOME: ACAD11 | ||
| Pathway Commons: ACAD11 | ||
| Context | iHOP: ACAD11 | |
| ligand binding site mutation search in PubMed: ACAD11 | ||
| UCL Cancer Institute: ACAD11 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase | 21237683 |
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| Ligand binding site mutations for ACAD11 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L664,F660 | K662N | HNSC | 1 | F504 | C503S | KIRC | 1 | V759 | L761F | SKCM | 1 | A512 | A512S | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ACAD11 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V759 | L761F | -1.0749511 | F504 | C503S | -1.0101685 | A512 | A512S | -0.97412459 | L664 | K662N | -0.41540301 | F660 | K662N | -0.41540301 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ACAD11 from PDB |
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| Differential gene expression and gene-gene network for ACAD11 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ACAD11 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ACAD11 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ACAD11 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of ACAD11 |
| Multiple alignments for Q709F0 in multiple species |
| LBS | AA sequence | # species | Species | A512 | TEPDVASSDAT | 2 | Homo sapiens, Gallus gallus | A512 | TEPNVSSSDAT | 2 | Mus musculus, Rattus norvegicus | E758 | ADGPDEVHLSA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E758 | ADGPDEVHLST | 1 | Gallus gallus | F504 | DITSVFCMTEP | 2 | Mus musculus, Rattus norvegicus | F504 | NITSCFCMTEP | 1 | Homo sapiens | F504 | KISSCFCMTEP | 1 | Gallus gallus | F660 | TQRIAFKKKLY | 1 | Homo sapiens | F660 | AQRETFGKKLY | 1 | Gallus gallus | F660 | VQREAFKKKLY | 1 | Mus musculus | F660 | VQREAFGKKLY | 1 | Rattus norvegicus | G730 | AIQVCGGAGVS | 2 | Homo sapiens, Gallus gallus | G730 | AIQVHGGAGVS | 2 | Mus musculus, Rattus norvegicus | G731 | IQVCGGAGVSQ | 2 | Homo sapiens, Gallus gallus | G731 | IQVHGGAGVSQ | 2 | Mus musculus, Rattus norvegicus | H598 | NFHGGHFEIHF | 1 | Homo sapiens | H598 | EIHGGHFEVHF | 1 | Gallus gallus | H598 | NMHGGHWEVHF | 1 | Mus musculus | H598 | NVHGGHWEVHF | 1 | Rattus norvegicus | H667 | KKLYEHEVVAH | 2 | Mus musculus, Rattus norvegicus | H667 | KKLYAHEVVAH | 1 | Homo sapiens | H667 | KKLYHHEVVAH | 1 | Gallus gallus | L664 | AFKKKLYAHEV | 1 | Homo sapiens | L664 | TFGKKLYHHEV | 1 | Gallus gallus | L664 | AFKKKLYEHEV | 1 | Mus musculus | L664 | AFGKKLYEHEV | 1 | Rattus norvegicus | L752 | IRTLRLADGPD | 2 | Mus musculus, Rattus norvegicus | L752 | TRVLRLADGPD | 1 | Homo sapiens | L752 | IRTLRVADGPD | 1 | Gallus gallus | M506 | TSVFCMTEPNV | 2 | Mus musculus, Rattus norvegicus | M506 | TSCFCMTEPDV | 1 | Homo sapiens | M506 | SSCFCMTEPDV | 1 | Gallus gallus | P756 | RLADGPDEVHL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P756 | RVADGPDEVHL | 1 | Gallus gallus | Q727 | VDWAIQVCGGA | 1 | Homo sapiens | Q727 | IDCAIQVCGGA | 1 | Gallus gallus | Q727 | ADWAIQVHGGA | 1 | Mus musculus | Q727 | ADRAIQVHGGA | 1 | Rattus norvegicus | R657 | ERATQRIAFKK | 1 | Homo sapiens | R657 | QRAAQRETFGK | 1 | Gallus gallus | R657 | DRAVQREAFKK | 1 | Mus musculus | R657 | DRAVQREAFGK | 1 | Rattus norvegicus | S513 | EPDVASSDATN | 2 | Homo sapiens, Gallus gallus | S513 | EPNVSSSDATN | 2 | Mus musculus, Rattus norvegicus | S514 | PDVASSDATNI | 1 | Homo sapiens | S514 | PDVASSDATNM | 1 | Gallus gallus | S514 | PNVSSSDATNI | 1 | Mus musculus | S514 | PNVSSSDATNM | 1 | Rattus norvegicus | S540 | KKWWSSGAGNP | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | T507 | SCFCMTEPDVA | 2 | Homo sapiens, Gallus gallus | T507 | SVFCMTEPNVS | 2 | Mus musculus, Rattus norvegicus | V728 | DWAIQVCGGAG | 1 | Homo sapiens | V728 | DCAIQVCGGAG | 1 | Gallus gallus | V728 | DWAIQVHGGAG | 1 | Mus musculus | V728 | DRAIQVHGGAG | 1 | Rattus norvegicus | V734 | HGGAGVSQDYP | 2 | Mus musculus, Rattus norvegicus | V734 | CGGAGVSQDYP | 1 | Homo sapiens | V734 | CGGAGVSQDFP | 1 | Gallus gallus | V749 | YAIIRTLRLAD | 2 | Mus musculus, Rattus norvegicus | V749 | YAITRVLRLAD | 1 | Homo sapiens | V749 | FAYIRTLRVAD | 1 | Gallus gallus | V759 | DGPDEVHLSAI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V759 | DGPDEVHLSTI | 1 | Gallus gallus | W538 | NGKKWWSSGAG | 3 | Homo sapiens, Gallus gallus, Mus musculus | W538 | HGKKWWSSGAG | 1 | Rattus norvegicus |
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