mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for KAT8
Gene summary
Basic gene Info.Gene symbolKAT8
Gene nameK(lysine) acetyltransferase 8
SynonymsMOF|MYST1|ZC2HC8|hMOF
CytomapUCSC genome browser: 16p11.2
Type of geneprotein-coding
RefGenesNM_032188.2,
NM_182958.2,
DescriptionMOZ, YBF2/SAS3, SAS2 and TIP60 protein 1MYST histone acetyltransferase 1MYST-1histone acetyltransferase KAT8histone acetyltransferase MYST1lysine acetyltransferase 8ortholog of Drosophila males absent on the first (MOF)probable histone acetyltransf
Modification date20141207
dbXrefs MIM : 609912
HGNC : HGNC
Ensembl : ENSG00000103510
HPRD : 11381
Vega : OTTHUMG00000132410
ProteinUniProt: Q9H7Z6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KAT8
BioGPS: 84148
PathwayNCI Pathway Interaction Database: KAT8
KEGG: KAT8
REACTOME: KAT8
Pathway Commons: KAT8
ContextiHOP: KAT8
ligand binding site mutation search in PubMed: KAT8
UCL Cancer Institute: KAT8
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0010506regulation of autophagy23863932
GO:0016573histone acetylation11742995
GO:0030099myeloid cell differentiation11742995
GO:0043981histone H4-K5 acetylation20018852
GO:0043982histone H4-K8 acetylation20018852
GO:0043984histone H4-K16 acetylation20018852
GO:0045892negative regulation of transcription, DNA-templated11742995
GO:0045893positive regulation of transcription, DNA-templated11742995


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Ligand binding site mutations for KAT8
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R224R224GBRCA1
Q401L400MCOAD1
Y201Y201NLUAD1
S348G347SSKCM1
W192W192SSKCM1
E188E188KSTAD1
N186G185ESTAD1
Y201,E199D200NUCEC1
L271L271QUCEC1
Y201K203EUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for KAT8
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
W192W192S-2.0648599
L271L271Q-1.7477594
E199D200N-1.6136828
Y201D200N-1.6136828
R224R224G-1.2862461
Y201Y201N-0.98874581
E188E188K-0.77452916
S348G347S-0.50218083
Q401L400M-0.46966821
N186G185E-0.4048939
Y201K203E-0.1633981
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KAT8 from PDB

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Differential gene expression and gene-gene network for KAT8
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of KAT8 and the right PPI network was created from samples without mutations in the LBS of KAT8. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for KAT8
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for KAT8
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KAT8 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (LEU,GLU,ASN,LEU,ASP,ASP,SER,VAL,PHE,SER,LYS,ARG,HIS,ALA,LYS,LEU,GLU,LEU,ASP,GLU,LYS,ARG,ARG,LYS,ARG)4dncAE199 Y201
IIIPeptide ligand (LEU,ALA,VAL,PRO,SER,TRP,ARG,ASP,HIS,SER,VAL,GLU,PRO,LEU,ARG,ASP,PRO)4dncAN186 E188 W192 R224
IIIPeptide ligand (LEU,ALA,VAL,PRO,SER,TRP,ARG,ASP,HIS,SER,VAL,GLU,PRO,LEU)4dncBN186 E188 W192 R224
IIIPeptide ligand (LEU,ALA,VAL,PRO,SER,TRP,ARG,ASP,HIS,SER,VAL,GLU,PRO,LEU,ARG,ASP,PRO)4dncBQ401
IIIPeptide ligand (LEU,ALA,VAL,PRO,SER,TRP,ARG,ASP,HIS,SER,VAL,GLU,PRO,LEU)4dncAS348 Q401
COACOENZYME A2pq8AW192 L271
ACOACETYL COENZYME *A2y0mAW192 L271
IIIPeptide ligand (LEU,LEU,GLU,ASN,LEU,ASP,ASP,SER,VAL,PHE,SER,LYS,ARG,HIS,ALA,LYS,LEU,GLU,LEU,ASP,GLU,LYS,ARG,ARG,LYS,ARG,TRP)4dncBY201


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Conservation information for LBS of KAT8
Multiple alignments for Q9H7Z6 in multiple species
LBSAA sequence# speciesSpecies
A315DGNNVACILTL3Homo sapiens, Mus musculus, Rattus norvegicus
A315EAYNLACILTL2Arabidopsis thaliana, Arabidopsis thaliana
A315ESYNLACILTL1Oryza sativa subsp. japonica
A315ENYNVACILVL1Drosophila melanogaster
C210PKLWLCEYCLK3Homo sapiens, Mus musculus, Rattus norvegicus
C210VKLFFCEFCLS1Arabidopsis thaliana
C210VKLFFCEFCLN1Arabidopsis thaliana
C210PKLFFCEFCLN1Oryza sativa subsp. japonica
C210RTLYVCEYCLK1Drosophila melanogaster
C213WLCEYCLKYMK3Homo sapiens, Mus musculus, Rattus norvegicus
C213FFCEFCLNFMK2Arabidopsis thaliana, Oryza sativa subsp. japonica
C213FFCEFCLSFMK1Arabidopsis thaliana
C213YVCEYCLKYMR1Drosophila melanogaster
C230FHLGQCQWRQP3Homo sapiens, Mus musculus, Rattus norvegicus
C230RHMRKCDLKHP2Arabidopsis thaliana, Arabidopsis thaliana
C230RHMKKCDLKHP1Oryza sativa subsp. japonica
C230YHLHECDRRRP1Drosophila melanogaster
C316GNNVACILTLP3Homo sapiens, Mus musculus, Rattus norvegicus
C316AYNLACILTLP2Arabidopsis thaliana, Arabidopsis thaliana
C316SYNLACILTLP1Oryza sativa subsp. japonica
C316NYNVACILVLP1Drosophila melanogaster
D190GNYEIDAWYFS3Homo sapiens, Mus musculus, Rattus norvegicus
D190GKYEIETWYFS2Arabidopsis thaliana, Arabidopsis thaliana
D190GRYEIDTWYFS1Oryza sativa subsp. japonica
D190GNYEIDTWYFS1Drosophila melanogaster
D279KTLYFDVEPFV3Homo sapiens, Mus musculus, Rattus norvegicus
D279KTLYYDVDLFL3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
D279KVLYFDMDPFL1Drosophila melanogaster
D395SITQNDIISTL3Homo sapiens, Mus musculus, Rattus norvegicus
D395AIKAEDILSTL2Arabidopsis thaliana, Arabidopsis thaliana
D395AIKADDILSTL1Oryza sativa subsp. japonica
D395GITHDDIIYTL1Drosophila melanogaster
E188HIGNYEIDAWY3Homo sapiens, Mus musculus, Rattus norvegicus
E188ELGKYEIETWY2Arabidopsis thaliana, Arabidopsis thaliana
E188ELGRYEIDTWY1Oryza sativa subsp. japonica
E188QFGNYEIDTWY1Drosophila melanogaster
E199FSPFPEDYGKQ3Homo sapiens, Mus musculus, Rattus norvegicus
E199FSPFPPEYNDC2Arabidopsis thaliana, Arabidopsis thaliana
E199FSPFPPEYNDS1Oryza sativa subsp. japonica
E199FSPFPEEYGKA1Drosophila melanogaster
E220NFMKRKEQLQR2Arabidopsis thaliana, Oryza sativa subsp. japonica
E220KYMKFEKSYRF2Mus musculus, Rattus norvegicus
E220KYMKYEKSYRF1Homo sapiens
E220SFMKRKEQLQR1Arabidopsis thaliana
E220KYMRFRSSYAY1Drosophila melanogaster
E350TVGSPEKPLSD3Homo sapiens, Mus musculus, Rattus norvegicus
E350KVGTPERPLSD3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
E350VIGSPEKPLSD1Drosophila melanogaster
F225EKSYRFHLGQC3Homo sapiens, Mus musculus, Rattus norvegicus
F225KEQLQRHMRKC2Arabidopsis thaliana, Arabidopsis thaliana
F225KEQLQRHMKKC1Oryza sativa subsp. japonica
F225RSSYAYHLHEC1Drosophila melanogaster
F270LLAKLFLDHKT3Homo sapiens, Mus musculus, Rattus norvegicus
F270YLAKLFLDHKT3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
F270LMAKLFLDHKV1Drosophila melanogaster
F278HKTLYFDVEPF3Homo sapiens, Mus musculus, Rattus norvegicus
F278HKTLYYDVDLF3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
F278HKVLYFDMDPF1Drosophila melanogaster
G327PYQRRGYGKFL3Homo sapiens, Mus musculus, Rattus norvegicus
G327PYQRKGYGKFL2Arabidopsis thaliana, Oryza sativa subsp. japonica
G327SYQRKGYGKFL1Arabidopsis thaliana
G327PHQRKGFGKLL1Drosophila melanogaster
G329QRRGYGKFLIA3Homo sapiens, Mus musculus, Rattus norvegicus
G329QRKGYGKFLIA3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
G329QRKGFGKLLIA1Drosophila melanogaster
G357PLSDLGKLSYR3Homo sapiens, Mus musculus, Rattus norvegicus
G357PLSDLGLLSYR2Arabidopsis thaliana, Oryza sativa subsp. japonica
G357PLSDLGLVSYR1Arabidopsis thaliana
G357PLSDLGRLSYR1Drosophila melanogaster
H183YVDKIHIGNYE3Homo sapiens, Mus musculus, Rattus norvegicus
H183NIATIELGKYE1Arabidopsis thaliana
H183NISTIELGKYE1Arabidopsis thaliana
H183NIAKIELGRYE1Oryza sativa subsp. japonica
H183YIDKLQFGNYE1Drosophila melanogaster
H226KSYRFHLGQCQ3Homo sapiens, Mus musculus, Rattus norvegicus
H226EQLQRHMRKCD2Arabidopsis thaliana, Arabidopsis thaliana
H226EQLQRHMKKCD1Oryza sativa subsp. japonica
H226SSYAYHLHECD1Drosophila melanogaster
I258GKDHKIYCQNL3Homo sapiens, Mus musculus, Rattus norvegicus
I258GKKNKVYAQNL2Arabidopsis thaliana, Arabidopsis thaliana
I258GKKNKVYGQNL1Oryza sativa subsp. japonica
I258GKEESLYCQLL1Drosophila melanogaster
I317NNVACILTLPP3Homo sapiens, Mus musculus, Rattus norvegicus
I317YNLACILTLPP2Arabidopsis thaliana, Oryza sativa subsp. japonica
I317YNLACILTLPS1Arabidopsis thaliana
I317YNVACILVLPP1Drosophila melanogaster
K215CEFCLNFMKRK2Arabidopsis thaliana, Oryza sativa subsp. japonica
K215CEYCLKYMKFE2Mus musculus, Rattus norvegicus
K215CEYCLKYMKYE1Homo sapiens
K215CEFCLSFMKRK1Arabidopsis thaliana
K215CEYCLKYMRFR1Drosophila melanogaster
K218CLNFMKRKEQL2Arabidopsis thaliana, Oryza sativa subsp. japonica
K218CLKYMKFEKSY2Mus musculus, Rattus norvegicus
K218CLKYMKYEKSY1Homo sapiens
K218CLSFMKRKEQL1Arabidopsis thaliana
K218CLKYMRFRSSY1Drosophila melanogaster
K257DGKDHKIYCQN3Homo sapiens, Mus musculus, Rattus norvegicus
K257DGKKNKVYAQN2Arabidopsis thaliana, Arabidopsis thaliana
K257DGKKNKVYGQN1Oryza sativa subsp. japonica
K257NGKEESLYCQL1Drosophila melanogaster
K330RRGYGKFLIAF3Homo sapiens, Mus musculus, Rattus norvegicus
K330RKGYGKFLIAF3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
K330RKGFGKLLIAF1Drosophila melanogaster
K351VGSPEKPLSDL3Homo sapiens, Mus musculus, Rattus norvegicus
K351VGTPERPLSDL3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
K351IGSPEKPLSDL1Drosophila melanogaster
K358LSDLGKLSYRS3Homo sapiens, Mus musculus, Rattus norvegicus
K358LSDLGLLSYRG2Arabidopsis thaliana, Oryza sativa subsp. japonica
K358LSDLGLVSYRG1Arabidopsis thaliana
K358LSDLGRLSYRS1Drosophila melanogaster
K432KSAQYKKPPIT3Homo sapiens, Mus musculus, Rattus norvegicus
K432KAA--GRGGLD2Arabidopsis thaliana, Arabidopsis thaliana
K432KAA--GRGGLE1Oryza sativa subsp. japonica
K432QLPQFKQPKLT1Drosophila melanogaster
L227SYRFHLGQCQW3Homo sapiens, Mus musculus, Rattus norvegicus
L227QLQRHMRKCDL2Arabidopsis thaliana, Arabidopsis thaliana
L227QLQRHMKKCDL1Oryza sativa subsp. japonica
L227SYAYHLHECDR1Drosophila melanogaster
L271LAKLFLDHKTL6Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica, Mus musculus, Rattus norvegicus
L271MAKLFLDHKVL1Drosophila melanogaster
L276LDHKTLYFDVE3Homo sapiens, Mus musculus, Rattus norvegicus
L276LDHKTLYYDVD3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
L276LDHKVLYFDMD1Drosophila melanogaster
L318NVACILTLPPY3Homo sapiens, Mus musculus, Rattus norvegicus
L318NLACILTLPPY2Arabidopsis thaliana, Oryza sativa subsp. japonica
L318NLACILTLPSY1Arabidopsis thaliana
L318NVACILVLPPH1Drosophila melanogaster
L353SPEKPLSDLGK3Homo sapiens, Mus musculus, Rattus norvegicus
L353TPERPLSDLGL3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
L353SPEKPLSDLGR1Drosophila melanogaster
L356KPLSDLGKLSY3Homo sapiens, Mus musculus, Rattus norvegicus
L356RPLSDLGLLSY2Arabidopsis thaliana, Oryza sativa subsp. japonica
L356RPLSDLGLVSY1Arabidopsis thaliana
L356KPLSDLGRLSY1Drosophila melanogaster
L359SDLGKLSYRSY3Homo sapiens, Mus musculus, Rattus norvegicus
L359SDLGLLSYRGY2Arabidopsis thaliana, Oryza sativa subsp. japonica
L359SDLGLVSYRGY1Arabidopsis thaliana
L359SDLGRLSYRSY1Drosophila melanogaster
M217FCLNFMKRKEQ2Arabidopsis thaliana, Oryza sativa subsp. japonica
M217YCLKYMKFEKS2Mus musculus, Rattus norvegicus
M217YCLKYMKYEKS1Homo sapiens
M217FCLSFMKRKEQ1Arabidopsis thaliana
M217YCLKYMRFRSS1Drosophila melanogaster
N186KIHIGNYEIDA3Homo sapiens, Mus musculus, Rattus norvegicus
N186TIELGKYEIET2Arabidopsis thaliana, Arabidopsis thaliana
N186KIELGRYEIDT1Oryza sativa subsp. japonica
N186KLQFGNYEIDT1Drosophila melanogaster
N262KIYCQNLCLLA3Homo sapiens, Mus musculus, Rattus norvegicus
N262KVYAQNLCYLA2Arabidopsis thaliana, Arabidopsis thaliana
N262KVYGQNLCYLA1Oryza sativa subsp. japonica
N262SLYCQLLCLMA1Drosophila melanogaster
N404TLQSLNMVKYW3Homo sapiens, Mus musculus, Rattus norvegicus
N404TLQSLELIQYR2Arabidopsis thaliana, Arabidopsis thaliana
N404TLQSLDLIQYR1Oryza sativa subsp. japonica
N404TLQSMKMIKYW1Drosophila melanogaster
P198YFSPFPEDYGK3Homo sapiens, Mus musculus, Rattus norvegicus
P198YFSPFPPEYND3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
P198YFSPFPEEYGK1Drosophila melanogaster
P321CILTLPPYQRR3Homo sapiens, Mus musculus, Rattus norvegicus
P321CILTLPPYQRK2Arabidopsis thaliana, Oryza sativa subsp. japonica
P321CILTLPSYQRK1Arabidopsis thaliana
P321CILVLPPHQRK1Drosophila melanogaster
P322ILTLPPYQRRG3Homo sapiens, Mus musculus, Rattus norvegicus
P322ILTLPPYQRKG2Arabidopsis thaliana, Oryza sativa subsp. japonica
P322ILTLPSYQRKG1Arabidopsis thaliana
P322ILVLPPHQRKG1Drosophila melanogaster
P349STVGSPEKPLS3Homo sapiens, Mus musculus, Rattus norvegicus
P349GKVGTPERPLS3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
P349GVIGSPEKPLS1Drosophila melanogaster
Q261HKIYCQNLCLL3Homo sapiens, Mus musculus, Rattus norvegicus
Q261NKVYAQNLCYL2Arabidopsis thaliana, Arabidopsis thaliana
Q261NKVYGQNLCYL1Oryza sativa subsp. japonica
Q261ESLYCQLLCLM1Drosophila melanogaster
Q324TLPPYQRRGYG3Homo sapiens, Mus musculus, Rattus norvegicus
Q324TLPPYQRKGYG2Arabidopsis thaliana, Oryza sativa subsp. japonica
Q324TLPSYQRKGYG1Arabidopsis thaliana
Q324VLPPHQRKGFG1Drosophila melanogaster
Q401IISTLQSLNMV3Homo sapiens, Mus musculus, Rattus norvegicus
Q401ILSTLQSLELI2Arabidopsis thaliana, Arabidopsis thaliana
Q401ILSTLQSLDLI1Oryza sativa subsp. japonica
Q401IIYTLQSMKMI1Drosophila melanogaster
R224RKEQLQRHMRK2Arabidopsis thaliana, Arabidopsis thaliana
R224FEKSYRFHLGQ2Mus musculus, Rattus norvegicus
R224YEKSYRFHLGQ1Homo sapiens
R224RKEQLQRHMKK1Oryza sativa subsp. japonica
R224FRSSYAYHLHE1Drosophila melanogaster
R325LPPYQRRGYGK3Homo sapiens, Mus musculus, Rattus norvegicus
R325LPPYQRKGYGK2Arabidopsis thaliana, Oryza sativa subsp. japonica
R325LPSYQRKGYGK1Arabidopsis thaliana
R325LPPHQRKGFGK1Drosophila melanogaster
R326PPYQRRGYGKF3Homo sapiens, Mus musculus, Rattus norvegicus
R326PPYQRKGYGKF2Arabidopsis thaliana, Oryza sativa subsp. japonica
R326PSYQRKGYGKF1Arabidopsis thaliana
R326PPHQRKGFGKL1Drosophila melanogaster
R362GKLSYRSYWSW3Homo sapiens, Mus musculus, Rattus norvegicus
R362GLLSYRGYWTR2Arabidopsis thaliana, Oryza sativa subsp. japonica
R362GLVSYRGYWTR1Arabidopsis thaliana
R362GRLSYRSYWAY1Drosophila melanogaster
S222MKRKEQLQRHM3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
S222MKFEKSYRFHL2Mus musculus, Rattus norvegicus
S222MKYEKSYRFHL1Homo sapiens
S222MRFRSSYAYHL1Drosophila melanogaster
S348ESTVGSPEKPL3Homo sapiens, Mus musculus, Rattus norvegicus
S348EGKVGTPERPL3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
S348EGVIGSPEKPL1Drosophila melanogaster
S354PEKPLSDLGKL3Homo sapiens, Mus musculus, Rattus norvegicus
S354PERPLSDLGLL2Arabidopsis thaliana, Oryza sativa subsp. japonica
S354PERPLSDLGLV1Arabidopsis thaliana
S354PEKPLSDLGRL1Drosophila melanogaster
S360DLGKLSYRSYW3Homo sapiens, Mus musculus, Rattus norvegicus
S360DLGLLSYRGYW2Arabidopsis thaliana, Oryza sativa subsp. japonica
S360DLGLVSYRGYW1Arabidopsis thaliana
S360DLGRLSYRSYW1Drosophila melanogaster
S363KLSYRSYWSWV3Homo sapiens, Mus musculus, Rattus norvegicus
S363LLSYRGYWTRV2Arabidopsis thaliana, Oryza sativa subsp. japonica
S363LVSYRGYWTRI1Arabidopsis thaliana
S363RLSYRSYWAYT1Drosophila melanogaster
S398QNDIISTLQSL3Homo sapiens, Mus musculus, Rattus norvegicus
S398AEDILSTLQSL2Arabidopsis thaliana, Arabidopsis thaliana
S398ADDILSTLQSL1Oryza sativa subsp. japonica
S398HDDIIYTLQSM1Drosophila melanogaster
S402ISTLQSLNMVK3Homo sapiens, Mus musculus, Rattus norvegicus
S402LSTLQSLELIQ2Arabidopsis thaliana, Arabidopsis thaliana
S402LSTLQSLDLIQ1Oryza sativa subsp. japonica
S402IYTLQSMKMIK1Drosophila melanogaster
T319VACILTLPPYQ3Homo sapiens, Mus musculus, Rattus norvegicus
T319LACILTLPPYQ2Arabidopsis thaliana, Oryza sativa subsp. japonica
T319LACILTLPSYQ1Arabidopsis thaliana
T319VACILVLPPHQ1Drosophila melanogaster
W192YEIDAWYFSPF3Homo sapiens, Mus musculus, Rattus norvegicus
W192YEIETWYFSPF2Arabidopsis thaliana, Arabidopsis thaliana
W192YEIDTWYFSPF2Oryza sativa subsp. japonica, Drosophila melanogaster
W365SYRSYWSWVLL3Homo sapiens, Mus musculus, Rattus norvegicus
W365SYRGYWTRVLL2Arabidopsis thaliana, Oryza sativa subsp. japonica
W365SYRGYWTRILL1Arabidopsis thaliana
W365SYRSYWAYTLL1Drosophila melanogaster
Y187IHIGNYEIDAW3Homo sapiens, Mus musculus, Rattus norvegicus
Y187IELGKYEIETW2Arabidopsis thaliana, Arabidopsis thaliana
Y187IELGRYEIDTW1Oryza sativa subsp. japonica
Y187LQFGNYEIDTW1Drosophila melanogaster
Y201PFPEDYGKQPK3Homo sapiens, Mus musculus, Rattus norvegicus
Y201PFPPEYNDCVK2Arabidopsis thaliana, Arabidopsis thaliana
Y201PFPPEYNDSPK1Oryza sativa subsp. japonica
Y201PFPEEYGKART1Drosophila melanogaster
Y216EFCLNFMKRKE2Arabidopsis thaliana, Oryza sativa subsp. japonica
Y216EYCLKYMKFEK2Mus musculus, Rattus norvegicus
Y216EYCLKYMKYEK1Homo sapiens
Y216EFCLSFMKRKE1Arabidopsis thaliana
Y216EYCLKYMRFRS1Drosophila melanogaster
Y219LNFMKRKEQLQ2Arabidopsis thaliana, Oryza sativa subsp. japonica
Y219LKYMKFEKSYR2Mus musculus, Rattus norvegicus
Y219LKYMKYEKSYR1Homo sapiens
Y219LSFMKRKEQLQ1Arabidopsis thaliana
Y219LKYMRFRSSYA1Drosophila melanogaster
Y223KRKEQLQRHMR2Arabidopsis thaliana, Arabidopsis thaliana
Y223KFEKSYRFHLG2Mus musculus, Rattus norvegicus
Y223KYEKSYRFHLG1Homo sapiens
Y223KRKEQLQRHMK1Oryza sativa subsp. japonica
Y223RFRSSYAYHLH1Drosophila melanogaster
Y277DHKTLYFDVEP3Homo sapiens, Mus musculus, Rattus norvegicus
Y277DHKTLYYDVDL3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
Y277DHKVLYFDMDP1Drosophila melanogaster
Y328YQRRGYGKFLI3Homo sapiens, Mus musculus, Rattus norvegicus
Y328YQRKGYGKFLI3Arabidopsis thaliana, Arabidopsis thaliana, Oryza sativa subsp. japonica
Y328HQRKGFGKLLI1Drosophila melanogaster
Y361LGKLSYRSYWS3Homo sapiens, Mus musculus, Rattus norvegicus
Y361LGLLSYRGYWT2Arabidopsis thaliana, Oryza sativa subsp. japonica
Y361LGLVSYRGYWT1Arabidopsis thaliana
Y361LGRLSYRSYWA1Drosophila melanogaster


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