mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ARID5B
Gene summary
Basic gene Info.Gene symbolARID5B
Gene nameAT rich interactive domain 5B (MRF1-like)
CytomapUCSC genome browser: 10q21.2
Type of geneprotein-coding
DescriptionARID domain-containing protein 5BAT-rich interactive domain-containing protein 5BMRF1-like proteinmodulator recognition factor 2 (MRF2)
Modification date20141211
dbXrefs MIM : 608538
Ensembl : ENSG00000150347
Vega : OTTHUMG00000018298
ProteinUniProt: Q14865
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ARID5B
BioGPS: 84159
PathwayNCI Pathway Interaction Database: ARID5B
Pathway Commons: ARID5B
ContextiHOP: ARID5B
ligand binding site mutation search in PubMed: ARID5B
UCL Cancer Institute: ARID5B
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0000122negative regulation of transcription from RNA polymerase II promoter8649988
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity21532585

Ligand binding site mutations for ARID5B

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ARID5B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ARID5B from PDB

Differential gene expression and gene-gene network for ARID5B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ARID5B and the right PPI network was created from samples without mutations in the LBS of ARID5B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ARID5B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1961102Precursor Cell Lymphoblastic Leukemia-Lymphoma6Biomarker, GeneticVariation
umls:C0003873Arthritis, Rheumatoid4Biomarker, GeneticVariation
umls:C0018213Graves Disease2Biomarker
umls:C0010606Carcinoma, Adenoid Cystic1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ARID5B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ARID5B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ARID5B
Multiple alignments for Q14865 in multiple species
LBSAA sequence# speciesSpecies
C393TSAATCTRRHY3Homo sapiens, Gallus gallus, Mus musculus
G346RIPYLGFKQIN3Homo sapiens, Gallus gallus, Mus musculus
G386LGGNPGSTSAA3Homo sapiens, Gallus gallus, Mus musculus
H397TCTRRHYERLI3Homo sapiens, Gallus gallus, Mus musculus
I342TPIERIPYLGF3Homo sapiens, Gallus gallus, Mus musculus
K23PYIFYKAFQFH2Homo sapiens, Mus musculus
K23PYVFYRAFRFQ1Gallus gallus
K375ARRQWKHIYDE3Homo sapiens, Gallus gallus, Mus musculus
L345ERIPYLGFKQI3Homo sapiens, Gallus gallus, Mus musculus
P343PIERIPYLGFK3Homo sapiens, Gallus gallus, Mus musculus
R253LKGRPRKKKPC2Homo sapiens, Gallus gallus
R253LKGRPRKKKTC1Mus musculus
R341KTPIERIPYLG3Homo sapiens, Gallus gallus, Mus musculus
R371ETITARRQWKH3Homo sapiens, Gallus gallus, Mus musculus
R372TITARRQWKHI3Homo sapiens, Gallus gallus, Mus musculus
S389NPGSTSAATCT3Homo sapiens, Gallus gallus, Mus musculus
T388GNPGSTSAATC3Homo sapiens, Gallus gallus, Mus musculus
T392STSAATCTRRH3Homo sapiens, Gallus gallus, Mus musculus
Y344IERIPYLGFKQ3Homo sapiens, Gallus gallus, Mus musculus

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