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mutLBSgeneDB |
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| Gene summary for STK24 |
 Gene summary |
| Basic gene Info. | Gene symbol | STK24 |
| Gene name | serine/threonine kinase 24 | |
| Synonyms | HEL-S-95|MST3|MST3B|STE20|STK3 | |
| Cytomap | UCSC genome browser: 13q31.2-q32.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001032296.3, NM_001286649.1,NM_003576.4, | |
| Description | STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)serine/threonine-protein kinase 24sterile 20-like kinase 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604984 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000102572 | ||
| HPRD : 10385 | ||
| Protein | UniProt: Q9Y6E0 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STK24 | |
| BioGPS: 8428 | ||
| Pathway | NCI Pathway Interaction Database: STK24 | |
| KEGG: STK24 | ||
| REACTOME: STK24 | ||
| Pathway Commons: STK24 | ||
| Context | iHOP: STK24 | |
| ligand binding site mutation search in PubMed: STK24 | ||
| UCL Cancer Institute: STK24 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 19604147 | GO:0042542 | response to hydrogen peroxide | 22291017 | GO:0046777 | protein autophosphorylation | 17046825 |
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| Ligand binding site mutations for STK24 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E40 | K38T | COAD | 1 | L163 | S165P | COAD | 1 | S118 | A119T | COAD | 1 | A160 | A160T | GBM | 1 | S46 | S46F | SKCM | 1 | K65 | I66T | STAD | 1 | E40,I42 | K41E | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for STK24 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S118 | A119T | 0.014671562 | K65 | I66T | -0.99575717 | E40 | K41E | -0.92096293 | I42 | K41E | -0.92096293 | A160 | A160T | -0.89670113 | S46 | S46F | -0.74299756 | L163 | S165P | -0.56039375 | E40 | K38T | -0.47985238 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for STK24 from PDB |
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| Differential gene expression and gene-gene network for STK24 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for STK24 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for STK24 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of STK24 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of STK24 |
| Multiple alignments for Q9Y6E0 in multiple species |
| LBS | AA sequence | # species | Species | A160 | RDIKAANVLLS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A160 | RDIKAANILLS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A173 | GEVKLADFGVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A173 | GNVKLADFGVA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A63 | TQKVVAIKIID | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A63 | SGDIIAIKQID | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D121 | GGSALDLLEPG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D121 | GGSVSGLLKMG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D174 | EVKLADFGVAG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D174 | NVKLADFGVAA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E112 | LWIIMEYLGGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E112 | LWILMEHMDGG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E40 | LFTKLEKIGKG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E40 | -YTLLRKLGSG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E82 | EDIQQEITVLS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E82 | TDIEQEVFMLS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F175 | VKLADFGVAGQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F175 | VKLADFGVAAQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F47 | IGKGSFGEVFK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F47 | LGSGSFGVVWK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G115 | IMEYLGGGSAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G115 | LMEHMDGGSVS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G116 | MEYLGGGSALD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G116 | MEHMDGGSVSG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G117 | EYLGGGSALDL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G117 | EHMDGGSVSGL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G43 | KLEKIGKGSFG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G43 | LLRKLGSGSFG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G45 | EKIGKGSFGEV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G45 | RKLGSGSFGVV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I109 | DTKLWIIMEYL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I109 | GYTLWILMEHM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I42 | TKLEKIGKGSF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I42 | TLLRKLGSGSF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I64 | QKVVAIKIIDL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I64 | GDIIAIKQIDL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K304 | LIDRYKRWKAE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K304 | LVQKENKLFDD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K307 | RYKRWKAEQSH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K307 | KENKLFDDSDQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K44 | LEKIGKGSFGE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K44 | LRKLGSGSFGV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K65 | KVVAIKIIDLE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K65 | DIIAIKQIDLE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L114 | IIMEYLGGGSA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L114 | ILMEHMDGGSV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L163 | KAANVLLSEH- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L163 | KAANILLSSST | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M111 | KLWIIMEYLGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M111 | TLWILMEHMDG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N161 | DIKAANVLLSE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N161 | DIKAANILLSS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S118 | YLGGGSALDLL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S118 | HMDGGSVSGLL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S46 | KIGKGSFGEVF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S46 | KLGSGSFGVVW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T95 | DSPYVTKYYGS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T95 | NSSNVIQYYGC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V50 | GSFGEVFKGID | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V50 | GSFGVVWKARE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y113 | WIIMEYLGGGS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y113 | WILMEHMDGGS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y303 | ELIDRYKRWKA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y303 | LLVQKENKLFD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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