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mutLBSgeneDB |
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| Gene summary for PCGF5 |
 Gene summary |
| Basic gene Info. | Gene symbol | PCGF5 |
| Gene name | polycomb group ring finger 5 | |
| Synonyms | RNF159 | |
| Cytomap | UCSC genome browser: 10q23.32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001256549.1, NM_001257101.1,NM_032373.4,NR_046310.1,NR_046435.1, | |
| Description | RING finger protein 159polycomb group RING finger protein 5ring finger protein (C3HC4 type) 159 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000180628 | ||
| HPRD : 17825 | ||
| Vega : OTTHUMG00000018740 | ||
| Protein | UniProt: Q86SE9 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PCGF5 | |
| BioGPS: 84333 | ||
| Pathway | NCI Pathway Interaction Database: PCGF5 | |
| KEGG: PCGF5 | ||
| REACTOME: PCGF5 | ||
| Pathway Commons: PCGF5 | ||
| Context | iHOP: PCGF5 | |
| ligand binding site mutation search in PubMed: PCGF5 | ||
| UCL Cancer Institute: PCGF5 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PCGF5 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C53 | P54Q | LUAD | 1 | C42 | V44F | LUAD | 1 | C34 | T32M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PCGF5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C53 | P54Q | -1.5891738 | C42 | V44F | -0.89208555 | C34 | T32M | -0.42375519 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PCGF5 from PDB |
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| Differential gene expression and gene-gene network for PCGF5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PCGF5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PCGF5 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PCGF5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4s3o | C | C34 C53 | ZN | ZINC(2+) | 4s3o | F | C34 C53 | ZN | ZINC(2+) | 4s3o | C | C42 | ZN | ZINC(2+) | 4s3o | F | C42 |
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| Conservation information for LBS of PCGF5 |
| Multiple alignments for Q86SE9 in multiple species |
| LBS | AA sequence | # species | Species | C18 | NPYITCYICKG | 3 | Homo sapiens, Mus musculus, Bos taurus | C18 | NRYITCSICRG | 1 | Danio rerio | C18 | NHFITCFVCKG | 1 | Danio rerio | C21 | ITCYICKGYLI | 3 | Homo sapiens, Mus musculus, Bos taurus | C21 | ITCSICRGYLI | 1 | Danio rerio | C21 | ITCFVCKGYLI | 1 | Danio rerio | C34 | TTVTECLHTFC | 4 | Homo sapiens, Mus musculus, Bos taurus, Danio rerio | C34 | TAVTECLHTFC | 1 | Danio rerio | C39 | CLHTFCKTCIV | 3 | Homo sapiens, Mus musculus, Bos taurus | C39 | CLHTFCKSCIV | 2 | Danio rerio, Danio rerio | C42 | TFCKTCIVQHF | 3 | Homo sapiens, Mus musculus, Bos taurus | C42 | TFCKSCIVQHF | 2 | Danio rerio, Danio rerio | C53 | EDSNDCPRCGN | 3 | Homo sapiens, Mus musculus, Bos taurus | C53 | EESNECPECGI | 1 | Danio rerio | C53 | EDSNDCPKCGI | 1 | Danio rerio | C56 | NDCPRCGNQVH | 3 | Homo sapiens, Mus musculus, Bos taurus | C56 | NECPECGIQVH | 1 | Danio rerio | C56 | NDCPKCGIQVH | 1 | Danio rerio | H36 | VTECLHTFCKT | 3 | Homo sapiens, Mus musculus, Bos taurus | H36 | VTECLHTFCKS | 2 | Danio rerio, Danio rerio |
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