mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CUL4B
Gene summary
Basic gene Info.Gene symbolCUL4B
Gene namecullin 4B
CytomapUCSC genome browser: Xq23
Type of geneprotein-coding
Modification date20141207
dbXrefs MIM : 300304
Ensembl : ENSG00000158290
HPRD : 02251
Vega : OTTHUMG00000022302
ProteinUniProt: Q13620
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CUL4B
BioGPS: 8450
PathwayNCI Pathway Interaction Database: CUL4B
Pathway Commons: CUL4B
ContextiHOP: CUL4B
ligand binding site mutation search in PubMed: CUL4B
UCL Cancer Institute: CUL4B
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0035518histone H2A monoubiquitination22334663
GO:0070914UV-damage excision repair22334663

Ligand binding site mutations for CUL4B
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CUL4B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CUL4B from PDB

Differential gene expression and gene-gene network for CUL4B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CUL4B and the right PPI network was created from samples without mutations in the LBS of CUL4B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CUL4B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1845861Mental Retardation, X-Linked, With Brachydactyly And Macroglossia2Biomarker, GeneticVariation
umls:C0017661Glomerulonephritis, IGA1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CUL4B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CUL4B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of CUL4B
Multiple alignments for Q13620 in multiple species
LBSAA sequence# speciesSpecies
A734HCVLKAEFKEG2Homo sapiens, Mus musculus
A734HCVLKADFSKG1Arabidopsis thaliana
C730STLGHCVLKAE2Homo sapiens, Mus musculus
C730NSLGHCVLKAD1Arabidopsis thaliana
C810GDKFICNDDFK2Homo sapiens, Mus musculus
C810GDEFEFNDEFA1Arabidopsis thaliana
D812KFICNDDFKHK2Homo sapiens, Mus musculus
D812EFEFNDEFAAP1Arabidopsis thaliana
E676VPGNIELTVNI2Homo sapiens, Mus musculus
E676LPSGIEMSVHV1Arabidopsis thaliana
E735CVLKAEFKEGK2Homo sapiens, Mus musculus
E735CVLKADFSKGK1Arabidopsis thaliana
E742KEGKKELQVSL2Homo sapiens, Mus musculus
E742SKGKKELAVSL1Arabidopsis thaliana
E760MFNEGEEFSLE2Homo sapiens, Mus musculus
E760LFNDAMKLSFE1Arabidopsis thaliana
F736VLKAEFKEGKK2Homo sapiens, Mus musculus
F736VLKADFSKGKK1Arabidopsis thaliana
G718LGKHSGRKLQW2Homo sapiens, Mus musculus
G718LSKYSGRRLMW1Arabidopsis thaliana
G728WQSTLGHCVLK2Homo sapiens, Mus musculus
G728WQNSLGHCVLK1Arabidopsis thaliana
H729QSTLGHCVLKA2Homo sapiens, Mus musculus
H729QNSLGHCVLKA1Arabidopsis thaliana
I675NVPGNIELTVN2Homo sapiens, Mus musculus
I675KLPSGIEMSVH1Arabidopsis thaliana
I681ELTVNILTMGY2Homo sapiens, Mus musculus
I681EMSVHVLTTGY1Arabidopsis thaliana
K720KHSGRKLQWQS2Homo sapiens, Mus musculus
K720KYSGRRLMWQN1Arabidopsis thaliana
K733GHCVLKAEFKE2Homo sapiens, Mus musculus
K733GHCVLKADFSK1Arabidopsis thaliana
L677PGNIELTVNIL2Homo sapiens, Mus musculus
L677PSGIEMSVHVL1Arabidopsis thaliana
L682LTVNILTMGYW2Homo sapiens, Mus musculus
L682MSVHVLTTGYW1Arabidopsis thaliana
L721HSGRKLQWQST2Homo sapiens, Mus musculus
L721YSGRRLMWQNS1Arabidopsis thaliana
L727QWQSTLGHCVL2Homo sapiens, Mus musculus
L727MWQNSLGHCVL1Arabidopsis thaliana
L732LGHCVLKAEFK2Homo sapiens, Mus musculus
L732LGHCVLKADFS1Arabidopsis thaliana
L747ELQVSLFQTLV1Homo sapiens
L747ELAVSLFQAVV1Arabidopsis thaliana
L747ELQVSLFQTMV1Mus musculus
L753FQTLVLLMFNE1Homo sapiens
L753FQAVVLMLFND1Arabidopsis thaliana
L753FQTMVLLMFNE1Mus musculus
L754QTLVLLMFNEG1Homo sapiens
L754QAVVLMLFNDA1Arabidopsis thaliana
L754QTMVLLMFNEG1Mus musculus
M684VNILTMGYWPT2Homo sapiens, Mus musculus
M684VHVLTTGYWPT1Arabidopsis thaliana
M701HLPPEMVKLQE2Homo sapiens, Mus musculus
M701KLPHELNVYQD1Arabidopsis thaliana
N757VLLMFNEGEEF2Homo sapiens, Mus musculus
N757VLMLFNDAMKL1Arabidopsis thaliana
Q705EMVKLQEIFKT2Homo sapiens, Mus musculus
Q705ELNVYQDIFKE1Arabidopsis thaliana
Q722SGRKLQWQSTL2Homo sapiens, Mus musculus
Q722SGRRLMWQNSL1Arabidopsis thaliana
Q724RKLQWQSTLGH2Homo sapiens, Mus musculus
Q724RRLMWQNSLGH1Arabidopsis thaliana
R719GKHSGRKLQWQ2Homo sapiens, Mus musculus
R719SKYSGRRLMWQ1Arabidopsis thaliana
T678GNIELTVNILT2Homo sapiens, Mus musculus
T678SGIEMSVHVLT1Arabidopsis thaliana
V679NIELTVNILTM2Homo sapiens, Mus musculus
V679GIEMSVHVLTT1Arabidopsis thaliana
V731TLGHCVLKAEF2Homo sapiens, Mus musculus
V731SLGHCVLKADF1Arabidopsis thaliana
W723GRKLQWQSTLG2Homo sapiens, Mus musculus
W723GRRLMWQNSLG1Arabidopsis thaliana
Y712IFKTFYLGKHS2Homo sapiens, Mus musculus
Y712IFKEFYLSKYS1Arabidopsis thaliana

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