mutLBSgeneDB |
Gene summary for TRIM63 |
Gene summary |
Basic gene Info. | Gene symbol | TRIM63 |
Gene name | tripartite motif containing 63, E3 ubiquitin protein ligase | |
Synonyms | IRF|MURF1|MURF2|RNF28|SMRZ | |
Cytomap | UCSC genome browser: 1p34-p33 | |
Type of gene | protein-coding | |
RefGenes | NM_032588.3, | |
Description | E3 ubiquitin-protein ligase TRIM63iris ring finger proteinmuscle specific ring finger protein 2muscle-specific RING finger protein 1ring finger protein 28striated muscle RING zinc finger proteintripartite motif-containing protein 63 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606131 | |
HGNC : HGNC | ||
Ensembl : ENSG00000158022 | ||
HPRD : 05843 | ||
Vega : OTTHUMG00000007510 | ||
Protein | UniProt: Q969Q1 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TRIM63 | |
BioGPS: 84676 | ||
Pathway | NCI Pathway Interaction Database: TRIM63 | |
KEGG: TRIM63 | ||
REACTOME: TRIM63 | ||
Pathway Commons: TRIM63 | ||
Context | iHOP: TRIM63 | |
ligand binding site mutation search in PubMed: TRIM63 | ||
UCL Cancer Institute: TRIM63 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for TRIM63 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | E128 | K129Q | COAD | 1 | C134 | C134S | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for TRIM63 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | E128 | K129Q | -1.5983404 | C134 | C134S | -1.4143142 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for TRIM63 from PDB |
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Differential gene expression and gene-gene network for TRIM63 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for TRIM63 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0026846 | Muscular Atrophy | 13 | AlteredExpression, Biomarker |
umls:C0878544 | Cardiomyopathies | 3 | Biomarker, GeneticVariation, Therapeutic |
umls:C0333641 | Atrophy | 1 | Biomarker |
umls:C0018800 | Cardiomegaly | 1 | Therapeutic |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for TRIM63 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of TRIM63 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of TRIM63 |
Multiple alignments for Q969Q1 in multiple species |
LBS | AA sequence | # species | Species |
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