mutLBSgeneDB |
Gene summary for HINT2 |
Gene summary |
Basic gene Info. | Gene symbol | HINT2 |
Gene name | histidine triad nucleotide binding protein 2 | |
Synonyms | HIT-17 | |
Cytomap | UCSC genome browser: 9p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_032593.2, | |
Description | HINT-2HINT-3HIT-17kDaPKCI-1-related HIT proteinhistidine triad nucleotide-binding protein 2, mitochondrialprotein kinase C inhibitor-2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609997 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137133 | ||
HPRD : 17106 | ||
Vega : OTTHUMG00000019886 | ||
Protein | UniProt: Q9BX68 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HINT2 | |
BioGPS: 84681 | ||
Pathway | NCI Pathway Interaction Database: HINT2 | |
KEGG: HINT2 | ||
REACTOME: HINT2 | ||
Pathway Commons: HINT2 | ||
Context | iHOP: HINT2 | |
ligand binding site mutation search in PubMed: HINT2 | ||
UCL Cancer Institute: HINT2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for HINT2 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | H151 | V152E | OV | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for HINT2 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H151 | V152E | -1.1490191 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for HINT2 from PDB |
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Differential gene expression and gene-gene network for HINT2 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for HINT2 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for HINT2 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of HINT2 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | AMP | AMP | 4ini | A | H151 | AMP | AMP | 4ini | B | H151 |
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Conservation information for LBS of HINT2 |
Multiple alignments for Q9BX68 in multiple species |
LBS | AA sequence | # species | Species | A142 | DGKLGAQSVYH | 2 | Homo sapiens, Bos taurus | A142 | DGKMGAQSVYH | 1 | Mus musculus | A82 | VFRDVAPQAPV | 2 | Homo sapiens, Mus musculus | A82 | AFRDVAPQAPV | 1 | Bos taurus | D80 | CLVFRDVAPQA | 2 | Homo sapiens, Mus musculus | D80 | CLAFRDVAPQA | 1 | Bos taurus | F56 | AAPTIFSRILD | 2 | Homo sapiens, Bos taurus | F56 | ASPTIFSRILD | 1 | Mus musculus | F78 | QQCLVFRDVAP | 2 | Homo sapiens, Mus musculus | F78 | QQCLAFRDVAP | 1 | Bos taurus | H149 | SVYHLHIHVLG | 3 | Homo sapiens, Mus musculus, Bos taurus | H151 | YHLHIHVLGGR | 3 | Homo sapiens, Mus musculus, Bos taurus | N136 | YRLVINDGKLG | 2 | Homo sapiens, Bos taurus | N136 | YRLVVNDGKMG | 1 | Mus musculus | Q143 | GKLGAQSVYHL | 2 | Homo sapiens, Bos taurus | Q143 | GKMGAQSVYHL | 1 | Mus musculus | R79 | QCLVFRDVAPQ | 2 | Homo sapiens, Mus musculus | R79 | QCLAFRDVAPQ | 1 | Bos taurus | S144 | KLGAQSVYHLH | 2 | Homo sapiens, Bos taurus | S144 | KMGAQSVYHLH | 1 | Mus musculus | S63 | RILDRSLPADI | 2 | Mus musculus, Bos taurus | S63 | RILDKSLPADI | 1 | Homo sapiens | V145 | LGAQSVYHLHI | 2 | Homo sapiens, Bos taurus | V145 | MGAQSVYHLHI | 1 | Mus musculus | V81 | LVFRDVAPQAP | 2 | Homo sapiens, Mus musculus | V81 | LAFRDVAPQAP | 1 | Bos taurus |
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