mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HINT2
Gene summary
Basic gene Info.Gene symbolHINT2
Gene namehistidine triad nucleotide binding protein 2
SynonymsHIT-17
CytomapUCSC genome browser: 9p13.3
Type of geneprotein-coding
RefGenesNM_032593.2,
DescriptionHINT-2HINT-3HIT-17kDaPKCI-1-related HIT proteinhistidine triad nucleotide-binding protein 2, mitochondrialprotein kinase C inhibitor-2
Modification date20141207
dbXrefs MIM : 609997
HGNC : HGNC
Ensembl : ENSG00000137133
HPRD : 17106
Vega : OTTHUMG00000019886
ProteinUniProt: Q9BX68
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HINT2
BioGPS: 84681
PathwayNCI Pathway Interaction Database: HINT2
KEGG: HINT2
REACTOME: HINT2
Pathway Commons: HINT2
ContextiHOP: HINT2
ligand binding site mutation search in PubMed: HINT2
UCL Cancer Institute: HINT2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for HINT2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H151V152EOV1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for HINT2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H151V152E-1.1490191
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HINT2 from PDB

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Differential gene expression and gene-gene network for HINT2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HINT2 and the right PPI network was created from samples without mutations in the LBS of HINT2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for HINT2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for HINT2
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HINT2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
AMPAMP4iniAH151
AMPAMP4iniBH151


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Conservation information for LBS of HINT2
Multiple alignments for Q9BX68 in multiple species
LBSAA sequence# speciesSpecies
A142DGKLGAQSVYH2Homo sapiens, Bos taurus
A142DGKMGAQSVYH1Mus musculus
A82VFRDVAPQAPV2Homo sapiens, Mus musculus
A82AFRDVAPQAPV1Bos taurus
D80CLVFRDVAPQA2Homo sapiens, Mus musculus
D80CLAFRDVAPQA1Bos taurus
F56AAPTIFSRILD2Homo sapiens, Bos taurus
F56ASPTIFSRILD1Mus musculus
F78QQCLVFRDVAP2Homo sapiens, Mus musculus
F78QQCLAFRDVAP1Bos taurus
H149SVYHLHIHVLG3Homo sapiens, Mus musculus, Bos taurus
H151YHLHIHVLGGR3Homo sapiens, Mus musculus, Bos taurus
N136YRLVINDGKLG2Homo sapiens, Bos taurus
N136YRLVVNDGKMG1Mus musculus
Q143GKLGAQSVYHL2Homo sapiens, Bos taurus
Q143GKMGAQSVYHL1Mus musculus
R79QCLVFRDVAPQ2Homo sapiens, Mus musculus
R79QCLAFRDVAPQ1Bos taurus
S144KLGAQSVYHLH2Homo sapiens, Bos taurus
S144KMGAQSVYHLH1Mus musculus
S63RILDRSLPADI2Mus musculus, Bos taurus
S63RILDKSLPADI1Homo sapiens
V145LGAQSVYHLHI2Homo sapiens, Bos taurus
V145MGAQSVYHLHI1Mus musculus
V81LVFRDVAPQAP2Homo sapiens, Mus musculus
V81LAFRDVAPQAP1Bos taurus


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