mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CAT
Gene summary
Basic gene Info.Gene symbolCAT
Gene namecatalase
Synonyms-
CytomapUCSC genome browser: 11p13
Type of geneprotein-coding
RefGenesNM_001752.3,
Description-
Modification date20141207
dbXrefs MIM : 115500
HGNC : HGNC
Ensembl : ENSG00000121691
HPRD : 00282
Vega : OTTHUMG00000044353
ProteinUniProt: P04040
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CAT
BioGPS: 847
PathwayNCI Pathway Interaction Database: CAT
KEGG: CAT
REACTOME: CAT
Pathway Commons: CAT
ContextiHOP: CAT
ligand binding site mutation search in PubMed: CAT
UCL Cancer Institute: CAT
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0001649osteoblast differentiation16210410
GO:0042744hydrogen peroxide catabolic process18379038
GO:0051262protein tetramerization10656833
GO:0051289protein homotetramerization21976670


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Ligand binding site mutations for CAT

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H362R363SCOAD2
F446,Q442R444QCOAD1
M350K349NCOAD1
R72R72THNSC1
R354,M350Q352HLUAD1
H362R363COV1
P151P151SSKCM1
P151P151LSKCM1
H362R363HUCEC1
F334D335NUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CAT
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R72R72T-1.3307657
P151P151S-1.2847382
F446R444Q-0.84259112
Q442R444Q-0.84259112
H362R363H-0.79333398
M350K349N-0.79192863
H362R363S-0.77400039
P151P151L-0.64317165
F334D335N-0.55788112
H362R363C-0.47590609
R354Q352H-0.4027586
M350Q352H-0.4027586
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CAT from PDB
PDB IDPDB titlePDB structure
1DGB"HUMAN ERYTHROCYTE CATALASE

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Differential gene expression and gene-gene network for CAT
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CAT and the right PPI network was created from samples without mutations in the LBS of CAT. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CAT
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0020538Hypertension15Biomarker, GeneticVariation
umls:C0011860Diabetes Mellitus, Type 215Biomarker, GeneticVariation, Therapeutic
umls:C0268419Acatalasia12Biomarker, GeneticVariation
umls:C0004096Asthma11Biomarker, GeneticVariation
umls:C0011849Diabetes Mellitus11Biomarker, GeneticVariation
umls:C0011854Diabetes Mellitus, Type 110Biomarker, GeneticVariation, Therapeutic
umls:C0027627Neoplasm Metastasis7Biomarker, GeneticVariation, Therapeutic
umls:C0022661Kidney Failure, Chronic5Biomarker, GeneticVariation
umls:C0003873Arthritis, Rheumatoid5AlteredExpression, Biomarker, GeneticVariation
umls:C0011853Diabetes Mellitus, Experimental4Biomarker, Therapeutic
umls:C0035126Reperfusion Injury4Biomarker
umls:C0038220Status Epilepticus4Biomarker, Therapeutic
umls:C0015695Fatty Liver3Biomarker
umls:C0011882Diabetic Neuropathies3Biomarker, GeneticVariation
umls:C0033860Psoriasis3Biomarker
umls:C0007131Carcinoma, Non-Small-Cell Lung3Biomarker
umls:C0878544Cardiomyopathies3Biomarker, Therapeutic
umls:C0007621Cell Transformation, Neoplastic3Therapeutic
umls:C0242656Disease Progression3Biomarker, Therapeutic
umls:C0036572Seizures3Biomarker, Therapeutic
umls:C0007786Brain Ischemia2Biomarker
umls:C0020550Hyperthyroidism2Biomarker
umls:C0027051Myocardial Infarction2Biomarker, Therapeutic
umls:C0027055Myocardial Reperfusion Injury2Biomarker, Therapeutic
umls:C0038358Stomach Ulcer2Biomarker, Therapeutic
umls:C0023891Liver Cirrhosis, Alcoholic2Biomarker, GeneticVariation
umls:C0027651Neoplasms2AlteredExpression, Therapeutic
umls:C0018801Heart Failure2Biomarker
umls:C0027540Necrosis2Therapeutic
umls:C0027626Neoplasm Invasiveness2Therapeutic
umls:C2936847Acatalasemia Japanese type2Biomarker, GeneticVariation
umls:C0032927Precancerous Conditions1Biomarker
umls:C0000771Abnormalities, Drug-Induced1Therapeutic
umls:C0242488Acute Lung Injury1Therapeutic
umls:C0993582Arthritis, Experimental1Biomarker
umls:C0004045Asphyxia Neonatorum1Biomarker
umls:C0004352Autistic Disorder1Biomarker
umls:C0004943Behcet Syndrome1Biomarker
umls:C0860207Drug-Induced Liver Injury1Biomarker
umls:C0013386Dyskinesia, Drug-Induced1Biomarker
umls:C0013604Edema1Biomarker
umls:C0017638Glioma1Biomarker
umls:C0019158Hepatitis1Biomarker
umls:C0020452Hyperemia1Therapeutic
umls:C0020649Hypotension1Therapeutic
umls:C0022593Keratosis1Biomarker
umls:C0079744Lymphoma, Large B-Cell, Diffuse1Biomarker
umls:C0025500Mesothelioma1Biomarker
umls:C0029458Osteoporosis, Postmenopausal1Biomarker
umls:C0349231Phobic Disorders1Biomarker
umls:C0033626Protein Deficiency1Biomarker
umls:C0034063Pulmonary Edema1Therapeutic
umls:C0034065Pulmonary Embolism1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CAT
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|vet_approvedDB01213FomepizoleSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CAT go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NDPNADPH1dgbAP151 Q442 F446
NDPNADPH1dgbCP151 Q442 F446
NDPNADPH1dgfAP151 Q442 F446
NDPNADPH1dgfCP151 Q442 F446
NDPNADPH1dggAP151 Q442 F446
NDPNADPH1dggCP151 Q442 F446
NDPNADPH1dghAP151 Q442 F446
NDPNADPH1dghCP151 Q442 F446
HEMHEME B1dgbAR72 F334 M350 R354 H362
HEMHEME B1dgbBR72 F334 M350 R354 H362
HEMHEME B1dgbCR72 F334 M350 R354 H362
HEMHEME B1dgbDR72 F334 M350 R354 H362
HEMHEME B1dgfAR72 F334 M350 R354 H362
HEMHEME B1dgfBR72 F334 M350 R354 H362
HEMHEME B1dgfCR72 F334 M350 R354 H362
HEMHEME B1dgfDR72 F334 M350 R354 H362
HEMHEME B1dggAR72 F334 M350 R354 H362
HEMHEME B1dggBR72 F334 M350 R354 H362
HEMHEME B1dggCR72 F334 M350 R354 H362
HEMHEME B1dggDR72 F334 M350 R354 H362
HEMHEME B1dghAR72 F334 M350 R354 H362
HEMHEME B1dghBR72 F334 M350 R354 H362
HEMHEME B1dghCR72 F334 M350 R354 H362
HEMHEME B1dghDR72 F334 M350 R354 H362
HEMHEME B1f4jAR72 F334 M350 R354 H362
HEMHEME B1f4jBR72 F334 M350 R354 H362
HEMHEME B1f4jCR72 F334 M350 R354 H362
HEMHEME B1f4jDR72 F334 M350 R354 H362
HEMHEME B1qqwAR72 F334 M350 R354 H362
HEMHEME B1qqwBR72 F334 M350 R354 H362
HEMHEME B1qqwCR72 F334 M350 R354 H362
HEMHEME B1qqwDR72 F334 M350 R354 H362


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Conservation information for LBS of CAT
Multiple alignments for P04040 in multiple species
LBSAA sequence# speciesSpecies
A357QGRLFAYPDTH5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
A357QGRIFSYTDTH2Caenorhabditis elegans, Caenorhabditis elegans
A357QTRVFSYADTQ1Arabidopsis thaliana
A357QTRIFSYADSQ1Arabidopsis thaliana
A357HGRLFSYSDTH1Drosophila melanogaster
A357QARLFSYADAH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A357QVRTFSYPDTH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D65EMAHFDRERIP7Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
D65KLANFDRERIP2Arabidopsis thaliana, Arabidopsis thaliana
D65EMSHFDRERIP1Drosophila melanogaster
D65SLAHFNRENIP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D65VFQHFDRERIP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F153NNTPIFFIRDA5Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
F153NNTPIFFIRDP2Homo sapiens, Caenorhabditis elegans
F153NNTPVFFIRDP2Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F153NNFPVFFIRDG1Arabidopsis thaliana
F153NNFPVFFVRDG1Arabidopsis thaliana
F153NNTPVFFLRDP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F161RDPILFPSFIH2Homo sapiens, Drosophila melanogaster
F161RDGMKFPDMVH2Arabidopsis thaliana, Arabidopsis thaliana
F161RDAILFPSFIH2Mus musculus, Canis lupus familiaris
F161RDPIHFPNFIH1Caenorhabditis elegans
F161RDAIHFPNFIH1Caenorhabditis elegans
F161RDAMLFPSFIH1Rattus norvegicus
F161RDALLFPSFIH1Bos taurus
F161RDPSKFPHFIH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F161RDPAKFPLFIH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F198LHQVSFLFSDR4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
F198LNMFTFLFDDI1Arabidopsis thaliana
F198LHMFSFLFDDL1Arabidopsis thaliana
F198LHQVMFLFSDR1Caenorhabditis elegans
F198IHQVMFLYSDR1Caenorhabditis elegans
F198AHQVCILFSDR1Drosophila melanogaster
F198LHQVTFLFSDR1Rattus norvegicus
F198IHQVMILFSDR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F198IHQVMILFSDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F334VEQMAFDPSNM3Mus musculus, Rattus norvegicus, Canis lupus familiaris
F334VEQIAFDPSNM1Homo sapiens
F334NEQLAFCPAII1Arabidopsis thaliana
F334NEQIAFCPALV1Arabidopsis thaliana
F334VEQSAFCPAHI1Caenorhabditis elegans
F334VEQAAFCPAHI1Caenorhabditis elegans
F334VEQIAFSPAHL1Drosophila melanogaster
F334VEQLAFDPSNM1Bos taurus
F334VEQAAFAPSTT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F334IEQAGFSPSHM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F446TQVRTFYTKVL2Mus musculus, Rattus norvegicus
F446TQVRTFYLKVL2Canis lupus familiaris, Bos taurus
F446TQVRAFYVNVL1Homo sapiens
F446KEPGERY-RTF1Arabidopsis thaliana
F446KQPGERY-RSW1Arabidopsis thaliana
F446DQPRQFWEKVL1Caenorhabditis elegans
F446EQPRQFWEKVL1Caenorhabditis elegans
F446GQVTDFWVHVL1Drosophila melanogaster
F446VQARNLY-RVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F446EQPRAFWQNVL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G131VRDPRGFAVKF5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
G131LRDPRGFAVKF2Arabidopsis thaliana, Arabidopsis thaliana
G131ARDPRGFAIKF1Caenorhabditis elegans
G131VRDPRGFSLKF1Caenorhabditis elegans
G131ARDPRGFAVKF1Drosophila melanogaster
G131VRDPRGFATKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G131ARDPRGFALKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G147NWDLVGNNTPI7Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
G147NFDLVGNNFPV2Arabidopsis thaliana, Arabidopsis thaliana
G147VWDLVGNNTPV1Drosophila melanogaster
G147NLDWVYNNTPV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G147IFDMVGNNTPV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G216HMNGYGSHTFK7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
G216HMDGSGVNTYM1Arabidopsis thaliana
G216HMEGAGVNTYM1Arabidopsis thaliana
G216FMNGYGAHTFK1Caenorhabditis elegans
G216SMHGYSGHTYK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G216FMDGFSSHTYK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H194---SLHQVSFL4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
H194---SLNMFTFL1Arabidopsis thaliana
H194---SLHMFSFL1Arabidopsis thaliana
H194---ALHQVMFL1Caenorhabditis elegans
H194---SIHQVMFL1Caenorhabditis elegans
H194---SAHQVCIL1Drosophila melanogaster
H194---SLHQVTFL1Rattus norvegicus
H194NQVAIHQVMIL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H194---SIHQVMIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H235VYCKFHYKTDQ5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
H235HYVKFHWKPTC2Arabidopsis thaliana, Arabidopsis thaliana
H235IYVKFHFKPTQ1Caenorhabditis elegans
H235IYCKFHFKPAQ1Caenorhabditis elegans
H235IYAKFHFKTDQ1Drosophila melanogaster
H235HYVQVHIKTDQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H235YYCKWHFITNQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H305TKVWPHKDYPL3Homo sapiens, Mus musculus, Rattus norvegicus
H305TKVWPHGDYPL3Caenorhabditis elegans, Caenorhabditis elegans, Bos taurus
H305TKTWPEDILPL1Arabidopsis thaliana
H305TKIWPEDILPL1Arabidopsis thaliana
H305TKVWSQKEYPL1Drosophila melanogaster
H305TKIWPHQDYPL1Canis lupus familiaris
H305TKVWPQGQFPL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H305TKVWPHKDVPM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H362AYPDTHRHRLG5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
H362SYADTQRHRLG1Arabidopsis thaliana
H362SYADSQRHRLG1Arabidopsis thaliana
H362SYTDTHFHRLG1Caenorhabditis elegans
H362SYTDTHYHRLG1Caenorhabditis elegans
H362SYSDTHRHRLG1Drosophila melanogaster
H362SYADAHRYRLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H362SYPDTHRHRLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H75PERVVHAKGAG8Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
H75PERVVHARGAS2Arabidopsis thaliana, Arabidopsis thaliana
H75PQRNPHAHGSG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H75PERVVHAKGSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I242KTDQGIKNLSV3Homo sapiens, Canis lupus familiaris, Bos taurus
I242KTDQGIKNLPV2Mus musculus, Rattus norvegicus
I242KPTCGVKSLLE1Arabidopsis thaliana
I242KPTCGIKCLSD1Arabidopsis thaliana
I242KPTQGVKNLTV1Caenorhabditis elegans
I242KPAQGSKNLDP1Caenorhabditis elegans
I242KTDQGIKNLDV1Drosophila melanogaster
I242KTDQGIKNLTI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I242ITNQGTKGLTN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K237CKFHYKTDQGI5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
K237VKFHWKPTCGV1Arabidopsis thaliana
K237VKFHWKPTCGI1Arabidopsis thaliana
K237VKFHFKPTQGV1Caenorhabditis elegans
K237CKFHFKPAQGS1Caenorhabditis elegans
K237AKFHFKTDQGI1Drosophila melanogaster
K237VQVHIKTDQGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K237CKWHFITNQGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L299FNPFDLTKVWP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L299FNPFDVTKVWP2Caenorhabditis elegans, Caenorhabditis elegans
L299FDPLDVTKTWP1Arabidopsis thaliana
L299FDPLDVTKIWP1Arabidopsis thaliana
L299YNPFDVTKVWS1Drosophila melanogaster
L299FNPFDLTKIWP1Canis lupus familiaris
L299FSVFDLTKVWP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L299YNIFDLTKVWP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M350PSPDKMLQGRL4Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
M350FSPDKMLQGRI2Caenorhabditis elegans, Caenorhabditis elegans
M350ASPDKMLQGRL1Homo sapiens
M350YSDDKLLQTRV1Arabidopsis thaliana
M350YSDDKLLQTRI1Arabidopsis thaliana
M350PSPDKMLHGRL1Drosophila melanogaster
M350ASADPVLQARL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M350VSADPVLQVRT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M61VFTDEMAHFDR5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
M61VYMDEMAHFDR2Caenorhabditis elegans, Caenorhabditis elegans
M61HLVEKLANFDR1Arabidopsis thaliana
M61HLLEKLANFDR1Arabidopsis thaliana
M61NFLDEMSHFDR1Drosophila melanogaster
M61NLIDSLAHFNR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M61HLIDVFQHFDR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N148WDLVGNNTPIF7Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
N148FDLVGNNFPVF2Arabidopsis thaliana, Arabidopsis thaliana
N148WDLVGNNTPVF1Drosophila melanogaster
N148LDWVYNNTPVF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N148FDMVGNNTPVF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N213GHRHMNGYGSH5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
N213DYRHMDGSGVN1Arabidopsis thaliana
N213DYRHMEGAGVN1Arabidopsis thaliana
N213GYRHMNGYGSH1Caenorhabditis elegans
N213GFRFMNGYGAH1Caenorhabditis elegans
N213GYCHMNGYGSH1Drosophila melanogaster
N213NYRSMHGYSGH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N213SYRFMDGFSSH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P151VGNNTPIFFIR7Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
P151VGNNFPVFFIR1Arabidopsis thaliana
P151VGNNFPVFFVR1Arabidopsis thaliana
P151VGNNTPVFFIR1Drosophila melanogaster
P151VYNNTPVFFIR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P151VGNNTPVFFLR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P158FFIRDPILFPS2Homo sapiens, Drosophila melanogaster
P158FFIRDAILFPS2Mus musculus, Canis lupus familiaris
P158FFIRDGMKFPD1Arabidopsis thaliana
P158FFVRDGMKFPD1Arabidopsis thaliana
P158FFIRDPIHFPN1Caenorhabditis elegans
P158FFIRDAIHFPN1Caenorhabditis elegans
P158FFIRDAMLFPS1Rattus norvegicus
P158FFIRDALLFPS1Bos taurus
P158FFIRDPSKFPH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P158FFLRDPAKFPL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P304LTKVWPHKDYP3Homo sapiens, Mus musculus, Rattus norvegicus
P304VTKVWPHGDYP2Caenorhabditis elegans, Caenorhabditis elegans
P304VTKTWPEDILP1Arabidopsis thaliana
P304VTKIWPEDILP1Arabidopsis thaliana
P304VTKVWSQKEYP1Drosophila melanogaster
P304LTKIWPHQDYP1Canis lupus familiaris
P304LTKVWPHGDYP1Bos taurus
P304LTKVWPQGQFP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P304LTKVWPHKDVP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q442EDNVTQVRTFY3Mus musculus, Rattus norvegicus, Canis lupus familiaris
Q442DDNVTQVRAFY1Homo sapiens
Q442ENNFKEPGERY1Arabidopsis thaliana
Q442ENNFKQPGERY1Arabidopsis thaliana
Q442DNNYDQPRQFW1Caenorhabditis elegans
Q442DHNYEQPRQFW1Caenorhabditis elegans
Q442EDNFGQVTDFW1Drosophila melanogaster
Q442DDNVTQVRTFY1Bos taurus
Q442DVDFVQARNLY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q442DVDFEQPRAFW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R112TPIAVRFSTVA4Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus
R112TPVIVRFSTVI2Arabidopsis thaliana, Arabidopsis thaliana
R112TPLLIRFSTVG1Caenorhabditis elegans
R112TPLLVRFSTVA1Caenorhabditis elegans
R112TPLAVRFSTVG1Drosophila melanogaster
R112TPIAVRFSTVT1Mus musculus
R112TKCLTRFSTVG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R112TPMVARFSTVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R203FLFSDR-GIPD5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
R203FLFDDI-GIPQ1Arabidopsis thaliana
R203FLFDDL-GIPQ1Arabidopsis thaliana
R203FLFSDR-GLPD1Caenorhabditis elegans
R203FLYSDR-GIPD1Caenorhabditis elegans
R203ILFSDR-GTPD1Drosophila melanogaster
R203ILFSDR-GTPA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R203ILFSDLGGTPY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R354KMLQGRLFAYP5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
R354KMLQGRIFSYT2Caenorhabditis elegans, Caenorhabditis elegans
R354KLLQTRVFSYA1Arabidopsis thaliana
R354KLLQTRIFSYA1Arabidopsis thaliana
R354KMLHGRLFSYS1Drosophila melanogaster
R354PVLQARLFSYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R354PVLQVRTFSYP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R365DTHRHRLGPNY6Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
R365DTQRHRLGPNY1Arabidopsis thaliana
R365DSQRHRLGPNY1Arabidopsis thaliana
R365DTHFHRLGPNY1Caenorhabditis elegans
R365DTHYHRLGPNY1Caenorhabditis elegans
R365DAHRYRLGPNF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R365DTHRHRLGANF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R72ERIPERVVHAK9Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R72ERIPERVVHAR2Arabidopsis thaliana, Arabidopsis thaliana
R72ENIPQRNPHAH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S201VSFLFSDR-GI4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
S201FTFLFDDI-GI1Arabidopsis thaliana
S201FSFLFDDL-GI1Arabidopsis thaliana
S201VMFLFSDR-GL1Caenorhabditis elegans
S201VMFLYSDR-GI1Caenorhabditis elegans
S201VCILFSDR-GT1Drosophila melanogaster
S201VTFLFSDR-GI1Rattus norvegicus
S201VMILFSDR-GT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S201VMILFSDLGGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S217MNGYGSHTFKL6Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
S217MDGSGVNTYML1Arabidopsis thaliana
S217MEGAGVNTYML1Arabidopsis thaliana
S217MNGYGSHTFKM1Caenorhabditis elegans
S217MNGYGAHTFKM1Caenorhabditis elegans
S217MHGYSGHTYKW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S217MDGFSSHTYKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T361FAYPDTHRHRL5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
T361FSYADTQRHRL1Arabidopsis thaliana
T361FSYADSQRHRL1Arabidopsis thaliana
T361FSYTDTHFHRL1Caenorhabditis elegans
T361FSYTDTHYHRL1Caenorhabditis elegans
T361FSYSDTHRHRL1Drosophila melanogaster
T361FSYADAHRYRL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T361FSYPDTHRHRL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V146GNWDLVGNNTP7Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
V146GNFDLVGNNFP2Arabidopsis thaliana, Arabidopsis thaliana
V146GVWDLVGNNTP1Drosophila melanogaster
V146GNLDWVYNNTP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V146GIFDMVGNNTP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V302FDLTKVWPHKD4Homo sapiens, Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V302FDVTKVWPHGD2Caenorhabditis elegans, Caenorhabditis elegans
V302LDVTKTWPEDI1Arabidopsis thaliana
V302LDVTKIWPEDI1Arabidopsis thaliana
V302FDVTKVWSQKE1Drosophila melanogaster
V302FDLTKIWPHQD1Canis lupus familiaris
V302FDLTKVWPHGD1Bos taurus
V302FDLTKVWPQGQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V450TFYTKVLNE--2Mus musculus, Rattus norvegicus
V450AFYVNVLNE--1Homo sapiens
V450ERY-RTFTP--1Arabidopsis thaliana
V450ERY-RSWDS--1Arabidopsis thaliana
V450QFWEKVLDT--1Caenorhabditis elegans
V450QFWEKVLKE--1Caenorhabditis elegans
V450DFWVHVLDK--1Drosophila melanogaster
V450TFYLKVLGE--1Canis lupus familiaris
V450TFYLKVLNE--1Bos taurus
V450NLY-RVLGKQP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V450AFWQNVLGKKP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V73RIPERVVHAKG9Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V73RIPERVVHARG2Arabidopsis thaliana, Arabidopsis thaliana
V73NIPQRNPHAHG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V74IPERVVHAKGA8Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
V74IPERVVHARGA2Arabidopsis thaliana, Arabidopsis thaliana
V74IPQRNPHAHGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V74IPERVVHAKGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W303DLTKVWPHKDY3Homo sapiens, Mus musculus, Rattus norvegicus
W303DVTKVWPHGDY2Caenorhabditis elegans, Caenorhabditis elegans
W303DVTKTWPEDIL1Arabidopsis thaliana
W303DVTKIWPEDIL1Arabidopsis thaliana
W303DVTKVWSQKEY1Drosophila melanogaster
W303DLTKIWPHQDY1Canis lupus familiaris
W303DLTKVWPHGDY1Bos taurus
W303DLTKVWPQGQF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W303DLTKVWPHKDV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y358GRLFAYPDTHR5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
Y358TRVFSYADTQR1Arabidopsis thaliana
Y358TRIFSYADSQR1Arabidopsis thaliana
Y358GRIFSYTDTHF1Caenorhabditis elegans
Y358GRIFSYTDTHY1Caenorhabditis elegans
Y358GRLFSYSDTHR1Drosophila melanogaster
Y358ARLFSYADAHR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y358VRTFSYPDTHR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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