mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for OGT
Gene summary
Basic gene Info.Gene symbolOGT
Gene nameO-linked N-acetylglucosamine (GlcNAc) transferase
SynonymsHRNT1|O-GLCNAC
CytomapUCSC genome browser: Xq13
Type of geneprotein-coding
RefGenesNM_181672.2,
NM_181673.2,NM_003605.3,
DescriptionO-GlcNAc transferase p110 subunitO-GlcNAc transferase subunit p110O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)O-linked N-acetylglucosamine transferase 110 kDa subunitUDP-N-ace
Modification date20141207
dbXrefs MIM : 300255
HGNC : HGNC
Ensembl : ENSG00000147162
HPRD : 02222
Vega : OTTHUMG00000033316
ProteinUniProt: O15294
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_OGT
BioGPS: 8473
PathwayNCI Pathway Interaction Database: OGT
KEGG: OGT
REACTOME: OGT
Pathway Commons: OGT
ContextiHOP: OGT
ligand binding site mutation search in PubMed: OGT
UCL Cancer Institute: OGT
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006110regulation of glycolytic process22923583
GO:0006493protein O-linked glycosylation21240259
GO:0006915apoptotic process20824293
GO:0032868response to insulin18288188
GO:0035020regulation of Rac protein signal transduction18288188
GO:0043085positive regulation of catalytic activity-
GO:0043981histone H4-K5 acetylation20018852
GO:0043982histone H4-K8 acetylation20018852
GO:0043984histone H4-K16 acetylation20018852
GO:0045862positive regulation of proteolysis21285374
GO:0045944positive regulation of transcription from RNA polymerase II promoter23222540
GO:0046626regulation of insulin receptor signaling pathway18288188
GO:0048015phosphatidylinositol-mediated signaling18288188
GO:0051571positive regulation of histone H3-K4 methylation-


Top
Ligand binding site mutations for OGT

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D430D430NBRCA1
N335A334GCOAD1
H527G528DCOAD1
H527N529KGBM1
D396D396NHNSC1
Y418T419MHNSC1
Y418R420GHNSC1
N400S399FKIRC1
R914G915CLUAD1
Y452T454KOV1
H568H568YSKCM1
D597P595LSKCM1
D328H326YSKCM1
N434L435MSTAD1
Y418Y418CUCEC1
Y642Y642HUCEC1
N335N335TUCEC1
A646R647QUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for OGT
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R914G915C0.26393071
N335A334G-1.2232868
N335N335T-1.1718331
Y642Y642H-1.1414738
N434L435M-1.1071223
Y418R420G-0.90264495
D396D396N-0.80563287
H527N529K-0.77809499
Y418T419M-0.76736337
A646R647Q-0.72354951
D430D430N-0.63438801
D328H326Y-0.43579333
D597P595L-0.36404239
H568H568Y-0.28683
Y418Y418C-0.27041461
Y452T454K-0.06002384
H527G528D-0.04086293
N400S399F-0.001274681
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for OGT from PDB

Top
Differential gene expression and gene-gene network for OGT
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of OGT and the right PPI network was created from samples without mutations in the LBS of OGT. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for OGT
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for OGT
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of OGT go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


Top
Conservation information for LBS of OGT
Multiple alignments for O15294 in multiple species
LBSAA sequence# speciesSpecies
A362FPEFAAAHSNL3Homo sapiens, Rattus norvegicus, Mus musculus
A362TTGLSAPFNNL1Arabidopsis thaliana
A362YPEFAAAHSNL1Caenorhabditis elegans
A646GYTKGARNELF3Homo sapiens, Rattus norvegicus, Mus musculus
A646GYTKGARNEIF2Arabidopsis thaliana, Caenorhabditis elegans
A906IFSPVAPKEEH3Homo sapiens, Rattus norvegicus, Mus musculus
A906IFTDVAMKSEH1Arabidopsis thaliana
A906VFSNVAAKEEH1Caenorhabditis elegans
C927LDTPLCNGHTT5Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
D10--NVADSTEPT2Homo sapiens, Mus musculus
D10KLDLSVSSSSS1Arabidopsis thaliana
D10QFQLNGATAVQ1Caenorhabditis elegans
D10--NVADST---1Rattus norvegicus
D294QPHFPDAYCNL4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
D294DPRFLEAYNNL1Arabidopsis thaliana
D328CPTHADSLNNL3Homo sapiens, Rattus norvegicus, Mus musculus
D328QPNHPQAMANL1Arabidopsis thaliana
D328CPTHADSQNNL1Caenorhabditis elegans
D396SPTFADAYSNM3Homo sapiens, Rattus norvegicus, Mus musculus
D396DPLAADALVNR1Arabidopsis thaliana
D396APTFADAYSNM1Caenorhabditis elegans
D430NPAFADAHSNL4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
D430RPTMAEAHANL1Arabidopsis thaliana
D441ASIHKDSGNIP3Homo sapiens, Rattus norvegicus, Mus musculus
D441ASAYKDSGHVE1Arabidopsis thaliana
D441ASIHKDAGNMA1Caenorhabditis elegans
D597ALSPDDGTNFR3Homo sapiens, Rattus norvegicus, Mus musculus
D597ALSANDNTEWR1Arabidopsis thaliana
D597ALSVNDGTNFR1Caenorhabditis elegans
D935HTTGMDVLWAG3Homo sapiens, Rattus norvegicus, Mus musculus
D935HTTGTDVLWAG1Arabidopsis thaliana
D935HTTGMDILWTG1Caenorhabditis elegans
E407GNTLKEMQDVQ3Homo sapiens, Rattus norvegicus, Mus musculus
E407GNTYKEIGRVT1Arabidopsis thaliana
E407GNTLKEMGDSS1Caenorhabditis elegans
F292ELQPHFPDAYC3Homo sapiens, Rattus norvegicus, Mus musculus
F292SRDPRFLEAYN1Arabidopsis thaliana
F292DLQPHFPDAYC1Caenorhabditis elegans
F360EVFPEFAAAHS3Homo sapiens, Rattus norvegicus, Mus musculus
F360AVTTGLSAPFN1Arabidopsis thaliana
F360EIYPEFAAAHS1Caenorhabditis elegans
F394RISPTFADAYS3Homo sapiens, Rattus norvegicus, Mus musculus
F394RIDPLAADALV1Arabidopsis thaliana
F394RIAPTFADAYS1Caenorhabditis elegans
F428QINPAFADAHS4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
F428NFRPTMAEAHA1Arabidopsis thaliana
F704MPHTFFIGDHA4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
F704LPHCYFVNDYK1Arabidopsis thaliana
F878LWLLRFPAVGE3Homo sapiens, Rattus norvegicus, Mus musculus
F878LWLLRFPAAGE1Arabidopsis thaliana
F878LWLLRFPYQGE1Caenorhabditis elegans
G664QAMWLGYPGTS3Homo sapiens, Rattus norvegicus, Mus musculus
G664QVSYMGFPGTT1Arabidopsis thaliana
G664QVMWLGYPSTS1Caenorhabditis elegans
G929TPLCNGHTTGM4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
G929TPLCNGHTTGT1Arabidopsis thaliana
H506RLPSVHPHHSM4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
H506VLPSVQPFHAI1Arabidopsis thaliana
H508PSVHPHHSMLY4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
H508PSVQPFHAIAY1Arabidopsis thaliana
H509SVHPHHSMLYP4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
H509SVQPFHAIAYP1Arabidopsis thaliana
H527AIAERHGNLCL3Homo sapiens, Rattus norvegicus, Mus musculus
H527EISRKYAAHC-1Arabidopsis thaliana
H527AIAAKHASLCF1Caenorhabditis elegans
H568SDFGNHPTSHL4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
H568SDFGNHPLSHL1Arabidopsis thaliana
H911APKEEHVRRGQ3Homo sapiens, Rattus norvegicus, Mus musculus
H911AMKSEHIRRSV1Arabidopsis thaliana
H911AAKEEHVRRGQ1Caenorhabditis elegans
H930PLCNGHTTGMD4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
H930PLCNGHTTGTD1Arabidopsis thaliana
K406MGNTLKEMQDV3Homo sapiens, Rattus norvegicus, Mus musculus
K406RGNTYKEIGRV1Arabidopsis thaliana
K406MGNTLKEMGDS1Caenorhabditis elegans
K440LASIHKDSGNI3Homo sapiens, Rattus norvegicus, Mus musculus
K440LASAYKDSGHV1Arabidopsis thaliana
K440LASIHKDAGNM1Caenorhabditis elegans
K644MNGYTKGARNE4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
K644LNGYTKGARNE1Arabidopsis thaliana
K852FNQLYKIDPST4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
K852FNQLYKMDPEI1Arabidopsis thaliana
K908SPVAPKEEHVR3Homo sapiens, Rattus norvegicus, Mus musculus
K908TDVAMKSEHIR1Arabidopsis thaliana
K908SNVAAKEEHVR1Caenorhabditis elegans
L573HPTSHLMQSIP4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
L573HPLSHLMGSVF1Arabidopsis thaliana
L663IQAMWLGYPGT3Homo sapiens, Rattus norvegicus, Mus musculus
L663IQVSYMGFPGT1Arabidopsis thaliana
L663IQVMWLGYPST1Caenorhabditis elegans
L876SVLWLLRFPAV3Homo sapiens, Rattus norvegicus, Mus musculus
L876SALWLLRFPAA1Arabidopsis thaliana
L876SILWLLRFPYQ1Caenorhabditis elegans
M511HPHHSMLYPLS4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
M511QPFHAIAYPID1Arabidopsis thaliana
N331HADSLNNLANI3Homo sapiens, Rattus norvegicus, Mus musculus
N331HPQAMANLGNI1Arabidopsis thaliana
N331HADSQNNLANI1Caenorhabditis elegans
N332ADSLNNLANIK3Homo sapiens, Rattus norvegicus, Mus musculus
N332PQAMANLGNIY1Arabidopsis thaliana
N332ADSQNNLANIK1Caenorhabditis elegans
N335LNNLANIKREQ3Homo sapiens, Rattus norvegicus, Mus musculus
N335MANLGNIYMEW1Arabidopsis thaliana
N335QNNLANIKREQ1Caenorhabditis elegans
N366AAAHSNLASVL3Homo sapiens, Rattus norvegicus, Mus musculus
N366SAPFNNLAIIY1Arabidopsis thaliana
N366AAAHSNLASIL1Caenorhabditis elegans
N400ADAYSNMGNTL4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
N400ADALVNRGNTY1Arabidopsis thaliana
N403YSNMGNTLKEM4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
N403LVNRGNTYKEI1Arabidopsis thaliana
N434ADAHSNLASIH4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
N434AEAHANLASAY1Arabidopsis thaliana
N468PDAYCNLAHCL3Homo sapiens, Rattus norvegicus, Mus musculus
N468PEATCNLLHTL1Arabidopsis thaliana
N468PDAYCNLAHCH1Caenorhabditis elegans
N567SSDFGNHPTSH4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
N567SSDFGNHPLSH1Arabidopsis thaliana
N848VYCNFNQLYKI3Homo sapiens, Rattus norvegicus, Mus musculus
N848IFACFNQLYKM1Arabidopsis thaliana
N848VFCNFNQLYKI1Caenorhabditis elegans
P569DFGNHPTSHLM4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
P569DFGNHPLSHLM1Arabidopsis thaliana
P666MWLGYPGTSGA3Homo sapiens, Rattus norvegicus, Mus musculus
P666SYMGFPGTTGA1Arabidopsis thaliana
P666MWLGYPSTSGA1Caenorhabditis elegans
P907FSPVAPKEEHV3Homo sapiens, Rattus norvegicus, Mus musculus
P907FTDVAMKSEHI1Arabidopsis thaliana
P907FSNVAAKEEHV1Caenorhabditis elegans
Q372LASVLQQQGKL3Homo sapiens, Rattus norvegicus, Mus musculus
Q372LAIIYKQQGNY1Arabidopsis thaliana
Q372LASILQQQGKL1Caenorhabditis elegans
Q409TLKEMQDVQGA3Homo sapiens, Rattus norvegicus, Mus musculus
Q409TYKEIGRVTEA1Arabidopsis thaliana
Q409TLKEMGDSSAA1Caenorhabditis elegans
Q849YCNFNQLYKID3Homo sapiens, Rattus norvegicus, Mus musculus
Q849FACFNQLYKMD1Arabidopsis thaliana
Q849FCNFNQLYKID1Caenorhabditis elegans
R338LANIKREQGNI3Homo sapiens, Rattus norvegicus, Mus musculus
R338LGNIYMEWNMM1Arabidopsis thaliana
R338LANIKREQGKI1Caenorhabditis elegans
R914EEHVRRGQLAD4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
R914SEHIRRSVLAD1Arabidopsis thaliana
S369HSNLASVLQQQ3Homo sapiens, Rattus norvegicus, Mus musculus
S369FNNLAIIYKQQ1Arabidopsis thaliana
S369HSNLASILQQQ1Caenorhabditis elegans
S437HSNLASIHKDS3Homo sapiens, Rattus norvegicus, Mus musculus
S437HANLASAYKDS1Arabidopsis thaliana
S437HSNLASIHKDA1Caenorhabditis elegans
S504KNRLPSVHPHH3Homo sapiens, Rattus norvegicus, Mus musculus
S504MSVLPSVQPFH1Arabidopsis thaliana
S504KKRLPSVHPHH1Caenorhabditis elegans
T570FGNHPTSHLMQ4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
T570FGNHPLSHLMG1Arabidopsis thaliana
T643NMNGYTKGARN4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
T643NLNGYTKGARN1Arabidopsis thaliana
T931LCNGHTTGMDV3Homo sapiens, Rattus norvegicus, Mus musculus
T931LCNGHTTGTDV1Arabidopsis thaliana
T931LCNGHTTGMDI1Caenorhabditis elegans
T932CNGHTTGMDVL3Homo sapiens, Rattus norvegicus, Mus musculus
T932CNGHTTGTDVL1Arabidopsis thaliana
T932CNGHTTGMDIL1Caenorhabditis elegans
V905IIFSPVAPKEE3Homo sapiens, Rattus norvegicus, Mus musculus
V905IIFTDVAMKSE1Arabidopsis thaliana
V905IVFSNVAAKEE1Caenorhabditis elegans
Y418GALQCYTRAIQ3Homo sapiens, Rattus norvegicus, Mus musculus
Y418EAIQDYMHAIN1Arabidopsis thaliana
Y418AAIACYNRAIQ1Caenorhabditis elegans
Y452EAIASYRTALK3Homo sapiens, Rattus norvegicus, Mus musculus
Y452AAITSYKQALL1Arabidopsis thaliana
Y452EAIQSYSTALK1Caenorhabditis elegans
Y642VNMNGYTKGAR3Homo sapiens, Rattus norvegicus, Mus musculus
Y642INLNGYTKGAR1Arabidopsis thaliana
Y642INMNGYTKGAR1Caenorhabditis elegans
Y851NFNQLYKIDPS4Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Mus musculus
Y851CFNQLYKMDPE1Arabidopsis thaliana


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas