mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SUV420H2
Gene summary
Basic gene Info.Gene symbolSUV420H2
Gene namesuppressor of variegation 4-20 homolog 2 (Drosophila)
CytomapUCSC genome browser: 19q13.42
Type of geneprotein-coding
Descriptionhistone-lysine N-methyltransferase SUV420H2lysine N-methyltransferase 5Csu(var)4-20 homolog 2suv4-20h2
Modification date20141207
dbXrefs MIM : 613198
Ensembl : ENSG00000133247
HPRD : 15454
Vega : OTTHUMG00000150483
ProteinUniProt: Q86Y97
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SUV420H2
BioGPS: 84787
PathwayNCI Pathway Interaction Database: SUV420H2
Pathway Commons: SUV420H2
ContextiHOP: SUV420H2
ligand binding site mutation search in PubMed: SUV420H2
UCL Cancer Institute: SUV420H2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for SUV420H2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SUV420H2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SUV420H2 from PDB

Differential gene expression and gene-gene network for SUV420H2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SUV420H2 and the right PPI network was created from samples without mutations in the LBS of SUV420H2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SUV420H2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SUV420H2
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SUV420H2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of SUV420H2
Multiple alignments for Q86Y97 in multiple species
LBSAA sequence# speciesSpecies
A121METNGAKIVST3Homo sapiens, Mus musculus, Rattus norvegicus
A179WLGPAAFINHD3Homo sapiens, Mus musculus, Rattus norvegicus
C185FINHDCKPNCK3Homo sapiens, Mus musculus, Rattus norvegicus
C229EKNEHCECYTC2Mus musculus, Rattus norvegicus
C229EKNEHCECHTC1Homo sapiens
C231NEHCECYTCER2Mus musculus, Rattus norvegicus
C231NEHCECHTCER1Homo sapiens
C234CECYTCERKGE2Mus musculus, Rattus norvegicus
C234CECHTCERKGE1Homo sapiens
E117TRYSMETNGAK3Homo sapiens, Mus musculus, Rattus norvegicus
E230KNEHCECYTCE2Mus musculus, Rattus norvegicus
E230KNEHCECHTCE1Homo sapiens
F160AGENDFSIMYS2Homo sapiens, Mus musculus
F160AGENDFSVMYS1Rattus norvegicus
F180LGPAAFINHDC3Homo sapiens, Mus musculus, Rattus norvegicus
F222YGEGFFGEKNE3Homo sapiens, Mus musculus, Rattus norvegicus
G120SMETNGAKIVS3Homo sapiens, Mus musculus, Rattus norvegicus
H183AAFINHDCKPN3Homo sapiens, Mus musculus, Rattus norvegicus
H32LGFRTHKMNVS3Homo sapiens, Mus musculus, Rattus norvegicus
I181GPAAFINHDCK3Homo sapiens, Mus musculus, Rattus norvegicus
M116CTRYSMETNGA3Homo sapiens, Mus musculus, Rattus norvegicus
N182PAAFINHDCKP3Homo sapiens, Mus musculus, Rattus norvegicus
Y114LPCTRYSMETN3Homo sapiens, Mus musculus, Rattus norvegicus
Y217EVTCFYGEGFF3Homo sapiens, Mus musculus, Rattus norvegicus

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