mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CBR4
Gene summary
Basic gene Info.Gene symbolCBR4
Gene namecarbonyl reductase 4
SynonymsSDR45C1
CytomapUCSC genome browser: 4q32.3
Type of geneprotein-coding
RefGenesNM_032783.4,
Description3-oxoacyl-[acyl-carrier-protein] reductasecarbonic reductase 4carbonyl reductase family member 4quinone reductase CBR4short chain dehydrogenase/reductase family 45C, member 1
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000145439
HPRD : 07859
Vega : OTTHUMG00000161025
ProteinUniProt: Q8N4T8
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CBR4
BioGPS: 84869
PathwayNCI Pathway Interaction Database: CBR4
KEGG: CBR4
REACTOME: CBR4
Pathway Commons: CBR4
ContextiHOP: CBR4
ligand binding site mutation search in PubMed: CBR4
UCL Cancer Institute: CBR4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CBR4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
T183T183IBLCA1
T186D188NCOAD1
I86R88SLUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CBR4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I86R88S-1.2656456
T186D188N-0.82314003
T183T183I-0.41941339
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CBR4 from PDB

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Differential gene expression and gene-gene network for CBR4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CBR4 and the right PPI network was created from samples without mutations in the LBS of CBR4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CBR4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CBR4
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CBR4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NAPNADP ZWITTERION4cqmBI86
NAPNADP ZWITTERION4cqmCI86
NAPNADP ZWITTERION4cqmKI86
NAPNADP ZWITTERION4cqmOI86 T183
NAPNADP ZWITTERION4cqmJI86 T183 T186
NAPNADP ZWITTERION4cqmFT183 T186


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Conservation information for LBS of CBR4
Multiple alignments for Q8N4T8 in multiple species
LBSAA sequence# speciesSpecies
A33LAV-IARNLEG1Homo sapiens
A33CHI-VGRNEFH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A33VLVNYARSAKE1Arabidopsis thaliana
A33IVL-LSRNKEA1Danio rerio
A33VAV-ISRDLEV1Xenopus tropicalis
A33LAI-VSRNLEV1Mus musculus
A33LAI-VARNLEV1Rattus norvegicus
A33LAI-VARNLEG1Bos taurus
A83NFLVNAAGINR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A83DTVVHAAGVLQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A83DVVVNNAGITR1Arabidopsis thaliana
A83GFLVNAAGINR1Danio rerio
A83DYLVNSAGIRR1Xenopus tropicalis
A84FLVNAAGINRD5Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Bos taurus
A84TVVHAAGVLQS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A84VVVNNAGITRD1Arabidopsis thaliana
A84YLVNSAGIRRD1Xenopus tropicalis
C55LAFS-CDVAKE1Homo sapiens
C55HTLTIADVQSD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C55ITFG-GDVSKA1Arabidopsis thaliana
C55LGLS-CDVSKE1Danio rerio
C55LALS-CDVSKE1Xenopus tropicalis
C55LAFR-CDVAKE1Mus musculus
C55LAFR-CNIAKE1Rattus norvegicus
C55LALS-CDVAKE1Bos taurus
D184GFVHTDMTKDL1Homo sapiens
D184GYVDTPMLSSQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D184GFIASDMTAEL1Arabidopsis thaliana
D184GLIHTDMTAGL1Danio rerio
D184GFIHTDMTLGL1Xenopus tropicalis
D184GFIRTDMTRHL1Mus musculus
D184GFIHTDMTKHL1Rattus norvegicus
D184GFIHTDMTKDL1Bos taurus
D56AFS-CDVAKE-1Homo sapiens
D56TLTIADVQSDM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D56TFG-GDVSKA-1Arabidopsis thaliana
D56GLS-CDVSKE-1Danio rerio
D56ALS-CDVSKE-1Xenopus tropicalis
D56AFR-CDVAKE-1Mus musculus
D56AFR-CNIAKE-1Rattus norvegicus
D56ALS-CDVAKE-1Bos taurus
G13FGGSRGIGRAV3Homo sapiens, Mus musculus, Bos taurus
G13FGGSRGIGKAV2Xenopus tropicalis, Rattus norvegicus
G13TGGSSGLGKRI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G13TGASRGIGKAI1Arabidopsis thaliana
G13FGGSRGIGRAA1Danio rerio
G134SIVNVGSIIGL2Mus musculus, Rattus norvegicus
G134SIVNVGSIVGL1Homo sapiens
G134LILNISSRLST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G134RIINISSVVGL1Arabidopsis thaliana
G134AIVNIGSVVGV1Danio rerio
G134AIVNIGSIVGH1Xenopus tropicalis
G134SIVNVGSVVGL1Bos taurus
G179NVVAPGFIHTD3Xenopus tropicalis, Rattus norvegicus, Bos taurus
G179NVVAPGFVHTD1Homo sapiens
G179NAISPGYVDTP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G179NVVCPGFIASD1Arabidopsis thaliana
G179NLVAPGLIHTD1Danio rerio
G179NVVAPGFIRTD1Mus musculus
G85LVNAAGINRDS2Mus musculus, Rattus norvegicus
G85LVNAAGINRDG1Homo sapiens
G85VVHAAGVLQSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G85VVNNAGITRDT1Arabidopsis thaliana
G85LVNAAGINRDA1Danio rerio
G85LVNSAGIRRDA1Xenopus tropicalis
G85LVNAAGINRDN1Bos taurus
G9VCAVFGGSRGI5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
G9KVLITGGSSGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G9VVVITGASRGI1Arabidopsis thaliana
G9LAVVFGGSRGI1Danio rerio
I14GGSRGIGRAVA3Homo sapiens, Mus musculus, Bos taurus
I14GGSSGLGKRIA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I14GASRGIGKAIA1Arabidopsis thaliana
I14GGSRGIGRAAS1Danio rerio
I14GGSRGIGKAVS1Xenopus tropicalis
I14GGSRGIGKAVA1Rattus norvegicus
I86VNAAGINRDSL2Mus musculus, Rattus norvegicus
I86VNAAGINRDGL1Homo sapiens
I86VHAAGVLQSSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I86VNNAGITRDTL1Arabidopsis thaliana
I86VNAAGINRDAL1Danio rerio
I86VNSAGIRRDAL1Xenopus tropicalis
I86VNAAGINRDNL1Bos taurus
K152VYSASKGGLVG2Homo sapiens, Bos taurus
K152VYAASKAGLES1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K152NYAAAKGGVIS1Arabidopsis thaliana
K152VYSASKAGLEG1Danio rerio
K152IYGASKEGLIG1Xenopus tropicalis
K152AYSATKGGLVG1Mus musculus
K152AYSATKGGLIG1Rattus norvegicus
M185FVHTDMTKDLK1Homo sapiens
M185YVDTPMLSSQI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M185FIASDMTAELG1Arabidopsis thaliana
M185LIHTDMTAGLA1Danio rerio
M185FIHTDMTLGLE1Xenopus tropicalis
M185FIRTDMTRHLK1Mus musculus
M185FIHTDMTKHLK1Rattus norvegicus
M185FIHTDMTKDLN1Bos taurus
N35V-IARNLEGAK1Homo sapiens
N35I-VGRNEFHLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N35VNYARSAKEAE1Arabidopsis thaliana
N35L-LSRNKEAAQ1Danio rerio
N35V-ISRDLEVAK1Xenopus tropicalis
N35I-VSRNLEVAK1Mus musculus
N35I-VARNLEVAK1Rattus norvegicus
N35I-VARNLEGAR1Bos taurus
P178VNVVAPGFIHT3Xenopus tropicalis, Rattus norvegicus, Bos taurus
P178VNVVAPGFVHT1Homo sapiens
P178VNAISPGYVDT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P178VNVVCPGFIAS1Arabidopsis thaliana
P178VNLVAPGLIHT1Danio rerio
P178VNVVAPGFIRT1Mus musculus
R12VFGGSRGIGRA4Homo sapiens, Danio rerio, Mus musculus, Bos taurus
R12VFGGSRGIGKA2Xenopus tropicalis, Rattus norvegicus
R12ITGGSSGLGKR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R12ITGASRGIGKA1Arabidopsis thaliana
R34AV-IARNLEGA1Homo sapiens
R34HI-VGRNEFHL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R34LVNYARSAKEA1Arabidopsis thaliana
R34VL-LSRNKEAA1Danio rerio
R34AV-ISRDLEVA1Xenopus tropicalis
R34AI-VSRNLEVA1Mus musculus
R34AI-VARNLEVA1Rattus norvegicus
R34AI-VARNLEGA1Bos taurus
S11AVFGGSRGIGR3Homo sapiens, Mus musculus, Bos taurus
S11AVFGGSRGIGK2Xenopus tropicalis, Rattus norvegicus
S11LITGGSSGLGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S11VITGASRGIGK1Arabidopsis thaliana
S11VVFGGSRGIGR1Danio rerio
S135IVNVGSIIGLK2Mus musculus, Rattus norvegicus
S135IVNVGSIVGLK1Homo sapiens
S135ILNISSRLSTY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S135IINISSVVGLI1Arabidopsis thaliana
S135IVNIGSVVGVK1Danio rerio
S135IVNIGSIVGHK1Xenopus tropicalis
S135IVNVGSVVGLK1Bos taurus
T106VSQLHTNLLGS1Homo sapiens
T106DSIICTNLVSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T106DEVIALNLTGV1Arabidopsis thaliana
T106LSVLHTNLLGS1Danio rerio
T106RSLLSVNLVGT1Xenopus tropicalis
T106ISQLHTNLLGS1Mus musculus
T106LSQLHTNLLGT1Rattus norvegicus
T106LSQLHTNLLGS1Bos taurus
T183PGFVHTDMTKD1Homo sapiens
T183PGYVDTPMLSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T183PGFIASDMTAE1Arabidopsis thaliana
T183PGLIHTDMTAG1Danio rerio
T183PGFIHTDMTLG1Xenopus tropicalis
T183PGFIRTDMTRH1Mus musculus
T183PGFIHTDMTKH1Rattus norvegicus
T183PGFIHTDMTKD1Bos taurus
T186VHTDMTKDLKE1Homo sapiens
T186VDTPMLSSQIR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T186IASDMTAELGE1Arabidopsis thaliana
T186IHTDMTAGLAE1Danio rerio
T186IHTDMTLGLEE1Xenopus tropicalis
T186IRTDMTRHLKE1Mus musculus
T186IHTDMTKHLKE1Rattus norvegicus
T186IHTDMTKDLNE1Bos taurus
V133GSIVNVGSIIG2Mus musculus, Rattus norvegicus
V133GSIVNVGSIVG1Homo sapiens
V133RLILNISSRLS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V133GRIINISSVVG1Arabidopsis thaliana
V133GAIVNIGSVVG1Danio rerio
V133GAIVNIGSIVG1Xenopus tropicalis
V133GSIVNVGSVVG1Bos taurus
V181VAPGFIHTDMT3Xenopus tropicalis, Rattus norvegicus, Bos taurus
V181VAPGFVHTDMT1Homo sapiens
V181ISPGYVDTPML1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V181VCPGFIASDMT1Arabidopsis thaliana
V181VAPGLIHTDMT1Danio rerio
V181VAPGFIRTDMT1Mus musculus
V57FS-CDVAKE-H1Homo sapiens
V57LTIADVQSDMK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V57FG-GDVSKA-T1Arabidopsis thaliana
V57LS-CDVSKE-E1Danio rerio
V57LS-CDVSKE-N1Xenopus tropicalis
V57FR-CDVAKE-Q1Mus musculus
V57FR-CNIAKE-G1Rattus norvegicus
V57LS-CDVAKE-H1Bos taurus
Y148SGQSVYSASKG2Homo sapiens, Bos taurus
Y148PGTSVYAASKA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y148IGQANYAAAKG1Arabidopsis thaliana
Y148AGQCVYSASKA1Danio rerio
Y148IGQSIYGASKE1Xenopus tropicalis
Y148VGQSAYSATKG1Mus musculus
Y148VGQAAYSATKG1Rattus norvegicus


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